Catalog No.
YHD42601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr82-Gly288
Predicted molecular weight
26.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20823
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
TCF-1, Hepatocyte nuclear factor 1-alpha, Transcription factor 1, HNF-1A, Liver-specific transcription factor LF-B1, LFB1, HNF-1-alpha, TCF1, HNF1A
HNF1A Mutations and Beta Cell Dysfunction in Diabetes. PMID: 35328643
Novel insights into genetics and clinics of the HNF1A-MODY. PMID: 31517624
HNF1A-AS1: A Tumor-associated Long Non-coding RNA. PMID: 35619319
HNF1A：From Monogenic Diabetes to Type 2 Diabetes and Gestational Diabetes Mellitus. PMID: 35299962
Unsupervised Clustering of Missense Variants in HNF1A Using Multidimensional Functional Data Aids Clinical Interpretation. PMID: 32910913
Meta-analysis of HNF1A-MODY3 variants among human population. PMID: 35673428
Reduced penetrance of MODY-associated HNF1A/HNF4A variants but not GCK variants in clinically unselected cohorts. PMID: 36257325
EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer. PMID: 30185552
Regulatory mechanisms and potential medical applications of HNF1A-AS1 in cancers. PMID: 35836869
Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population. PMID: 27899486
Differential expression of HNF1A and HNF1A-AS1 in colon cancer cells. PMID: 35184384
sh-HNF1A-AS1 reduces the epithelial-mesenchymal transition and stemness of esophageal cancer cells. PMID: 35188404
Where to for precision treatment of HNF1A-MODY? PMID: 35412067
m6A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization. PMID: 36230970
Variants influencing age at diagnosis of HNF1A-MODY. PMID: 36104811
Integrated bioinformatic analysis of HNF1A in human cancers. PMID: 33752475
HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks. PMID: 35327967
HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1. PMID: 36825600
Primary hepatocellular adenoma due to biallelic HNF1A mutations and its co-occurrence with MODY 3: case-report and review of the literature. PMID: 31754975
HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1. PMID: 33990627
An intron mutation of HNF1A causes abnormal splicing and impairs its activity as a transcription factor. PMID: 35081418
Novel Loss-of-Function Variant in HNF1a Induces β-Cell Dysfunction through Endoplasmic Reticulum Stress. PMID: 36361808
EGR1 modulated LncRNA HNF1A-AS1 drives glioblastoma progression via miR-22-3p/ENO1 axis. PMID: 34772911
HNF1A/CASC2 regulates pancreatic cancer cell proliferation through PTEN/Akt signaling. PMID: 28865121
Half-Life of Sulfonylureas in HNF1A and HNF4A Human MODY Patients is not Prolonged as Suggested by the Mouse Hnf1a(-/-) Model. PMID: 26446475
HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer. PMID: 32154941
Altered cortisol metabolism in individuals with HNF1A-MODY. PMID: 32395877
Elevated HNF1A expression promotes radiation-resistance via driving PI3K/AKT signaling pathway in esophageal squamous cell carcinoma cells. PMID: 34234870
Defective functions of HNF1A variants on BCL2L1 transactivation and beta-cell growth. PMID: 32684311
Long non-coding RNA HNF1A-AS1 induces 5-FU resistance of gastric cancer through miR-30b-5p/EIF5A2 pathway. PMID: 35092904
HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions. PMID: 33459938
The HNF1A-AS1/miR-92a-3p axis affects the radiosensitivity of non-small cell lung cancer by competitively regulating the JNK pathway. PMID: 33755848
HNF1A-AS1 Regulates Cell Migration, Invasion and Glycolysis via Modulating miR-124/MYO6 in Colorectal Cancer Cells. PMID: 32110048
Novel HNF1A gene mutation in maturity-onset diabetes of the young: A case report. PMID: 35317157
Long Noncoding RNA HNF1A-AS1 Regulates Osteosarcoma Advancement Through Modulating the miR-32-5p/HMGB1 Axis. PMID: 32706998
Fucosylated AGP glycopeptides as biomarkers of HNF1A-Maturity onset diabetes of the young. PMID: 35122907
[HNF1A-AS1 inhibits proliferation, migration and invasion of IL-6-induced hemangioma endothelial cells by targeting miR-363-3p]. PMID: 34729750
lncRNA HNF1A-AS1 modulates non-small cell lung cancer progression by targeting miR-149-5p/Cdk6. PMID: 31243821
LncRNA-HNF1A-AS1 functions as a competing endogenous RNA to activate PI3K/AKT signalling pathway by sponging miR-30b-3p in gastric cancer. PMID: 32336754
Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case-control study in the Tunisian population and a meta-analysis. PMID: 35109885
Functional HNF1A variants linked with T2DM risk in European-ancestry populations. PMID: 36323883
DNAJC12 activated by HNF1A enhances aerobic glycolysis and drug resistance in non-small cell lung cancer. PMID: 35571408
The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. PMID: 36202974
HNF1A-Induced lncRNA HCG18 Facilitates Gastric Cancer Progression by Upregulating DNAJB12 via miR-152-3p. PMID: 32801777
MYC-activated lncRNA HNF1A-AS1 overexpression facilitates glioma progression via cooperating with miR-32-5p/SOX4 axis. PMID: 33448691
Functional Analyses of HNF1A-MODY Variants Refine the Interpretation of Identified Sequence Variants. PMID: 32017842
HNF1A inhibition induces the resistance of pancreatic cancer cells to gemcitabine by targeting ABCB1. PMID: 31103629
HMGB1 Inhibits HNF1A to Modulate Liver Fibrogenesis via p65/miR-146b Signaling. PMID: 32833553
Reprogramming the spleen into a functioning 'liver' in vivo. PMID: 34996824
Granuloma annulare and necrobiosis lipoidica in a patient with HNF1A-MODY. PMID: 35551682
GATA1-Activated HNF1A-AS1 Facilitates the Progression of Triple-Negative Breast Cancer via Sponging miR-32-5p to Upregulate RNF38. PMID: 33603481
HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties. PMID: 30074477
HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells. PMID: 37137894
Long non-coding RNA HNF1A-AS1 upregulates OTX1 to enhance angiogenesis in colon cancer via the binding of transcription factor PBX3. PMID: 32325080
Quality of life assessment in patients with HNF1A-MODY and GCK-MODY. PMID: 30421137
Congenital hyperinsulinism due to mutations in HNF1A. PMID: 32325224
Long noncoding RNA HNF1A-AS1 regulates proliferation and apoptosis of glioma through activation of the JNK signaling pathway via miR-363-3p/MAP2K4. PMID: 32779194
HNF1A regulates the crosstalk between innate immune responses and MAFLD by mediating autophagic degradation of TBK1. PMID: 35944095
Deletion of HNF1A-AS1 Suppresses the Malignant Phenotypes of Breast Cancer Cells In Vitro and In Vivo Through Targeting miRNA-20a-5p/TRIM32 Axis. PMID: 32319789
Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma. PMID: 33250700
Incidence of HNF1A and GCK MODY Variants in a South African Population. PMID: 33363396
HNF1A gene p.I27L is associated with early-onset, maturity-onset diabetes of the young-like diabetes in Turkey. PMID: 31109344
Fruit and Vegetable Consumption Interacts With HNF1A Variants on the C-Reactive Protein. PMID: 35873425
Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. PMID: 35918471
Development of an exoglycosidase plate-based assay for detecting α1-3,4 fucosylation biomarker in individuals with HNF1A-MODY. PMID: 34939081
Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma. PMID: 28791380
Silencing long non-coding RNA HNF1A-AS1 inhibits growth and resistance to TAM of breast cancer cells via the microRNA-363/SERTAD3 axis. PMID: 33472456
A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY. PMID: 34951657
New clinical screening strategy to distinguish HNF1A variant-induced diabetes from young early-onset type 2 diabetes in a Chinese population. PMID: 32238361
Report of Prolonged Neonatal Hypoglycemia in Three Infants of Mothers With Variants in HNF1A. PMID: 36189138
Exosomal lncRNA HNF1A-AS1 affects cisplatin resistance in cervical cancer cells through regulating microRNA-34b/TUFT1 axis. PMID: 31827397
PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A. PMID: 34968487
Treatment Options for MODY Patients: A Systematic Review of Literature. PMID: 32583173
The lncRNA HNF1A-AS1 is a negative prognostic factor and promotes tumorigenesis in osteosarcoma. PMID: 28866868
Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations. PMID: 29493090
Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis. PMID: 34719039
Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes. PMID: 32001615
MODY probability calculator for GCK and HNF1A screening in a multiethnic background population. PMID: 31576961
Identification of a novel hepatocyte nuclear factor-1 alpha (HNF1A) variant in maturity onset diabetes of the young type 3 (HNF1A-MODY). PMID: 35466084
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer? PMID: 30581769
Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA. PMID: 30121369
A study of associations between CUBN, HNF1A, and LIPC gene polymorphisms and coronary artery disease. PMID: 33004870
For research use only. Not for human or drug use.
