Catalog No.
PHE20801
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SCNN1A (Tyr112-Thr543).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
ENaCA, SCNN1A, Epithelial Na(+) channel subunit alpha, SCNEA, SCNN1, Alpha-NaCH, Amiloride-sensitive sodium channel subunit alpha, Nonvoltage-gated sodium channel 1 subunit alpha, Alpha-ENaC
Purification
Purified by antigen affinity column.
Accession
P37088
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
SCNN1A Overexpression Correlates with Poor Prognosis and Immune Infiltrates in Ovarian Cancer. PMID: 35221714
HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation. PMID: 34558641
A Novel SCNN1A Variation in a Patient with Autosomal-recessive Pseudohypoaldosteronism Type 1. PMID: 33829730
Sodium channel 1 subunit alpha SCNN1A exerts oncogenic function in pancreatic cancer via accelerating cellular growth and metastasis. PMID: 35714697
Liddle Syndrome: Review of the Literature and Description of a New Case. PMID: 29534496
miR‑95 promotes osteosarcoma growth by targeting SCNN1A. PMID: 32323794
Upregulation of SCNN1A Promotes Cell Proliferation, Migration, and Predicts Poor Prognosis in Ovarian Cancer Through Regulating Epithelial-Mesenchymal Transformation. PMID: 31549859
Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases. PMID: 26772908
Novel SCNN1A gene splicing-site mutation causing autosomal recessive pseudohypoaldosteronism type 1 (PHA1) in two Italian patients belonging to the same small town. PMID: 34134742
Association of SCNN1A Single Nucleotide Polymorphisms with neonatal respiratory distress syndrome. PMID: 26611714
Clinical and genetic characteristics of the patients with hypertension and hypokalemia carrying a novel SCNN1A mutation. PMID: 36336351
A Selective Histone Deacetylase Inhibitor Induces Autophagy and Cell Death via SCNN1A Downregulation in Glioblastoma Cells. PMID: 36139696
Genetic variation of SCNN1A influences lung diffusing capacity in cystic fibrosis. PMID: 22776878
Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer. PMID: 34823420
DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes. PMID: 33916525
A case of SCNN1A splicing mutation presenting as mild systemic pseudohypoaldosteronism type 1. PMID: 23813355
Conditional gene targeting of the Scnn1a (alphaENaC) gene locus. PMID: 11857811
Identification of the pivotal role of SPP1 in kidney stone disease based on multiple bioinformatics analysis. PMID: 35016690
Extensive sequence analysis of CFTR, SCNN1A, SCNN1B, SCNN1G and SERPINA1 suggests an oligogenic basis for cystic fibrosis-like phenotypes. PMID: 23837941
A homozygous missense mutation in SCNN1A is responsible for a transient neonatal form of pseudohypoaldosteronism type 1. PMID: 21653223
A case of systemic pseudohypoaldosteronism with a novel mutation in the SCNN1A gene. PMID: 23031435
Novel mutations in the SCNN1A gene causing Pseudohypoaldosteronism type 1. PMID: 23762408
miR-125b inhibits hepatitis B virus expression in vitro through targeting of the SCNN1A gene. PMID: 25173609
Analysis of the mouse Scnn1a promoter in cortical collecting duct cells and in transgenic mice. PMID: 11406278
Five novel mutations in the SCNN1A gene causing autosomal recessive pseudohypoaldosteronism type 1. PMID: 23416952
A mild and transient form of autosomal recessive Pseudohypoaldosteronism type 1 (PHA1) caused by a novel mutation in the SCNN1A gene. PMID: 37134141
Use of constant denaturant capillary electrophoresis of pooled blood samples to identify single-nucleotide polymorphisms in the genes (Scnn1a and Scnn1b) encoding the alpha and beta subunits of the epithelial sodium channel. PMID: 11978598
Epithelial Sodium and Chloride Channels and Asthma. PMID: 26265620
Swelling-induced upregulation of miR-141-3p inhibits hepatocyte proliferation. PMID: 35287291
ENaC in Cholinergic Brush Cells. PMID: 30159312
Chromosomal localization of the genes encoding SCNN1A, BTG1, IFNG and MAOA on chicken chromosome 1 by fluorescence in-situ hybridization. PMID: 11592486
A case of severe systemic type 1 pseudohypoaldosteronism with 10 years of evolution. PMID: 35918792
Genetic heterogeneity and cystic fibrosis. PMID: 19551760
Accessibility of ENaC extracellular domain central core residues. PMID: 35339489
Epigenetics and arterial hypertension: the challenge of emerging evidence. PMID: 25035152
Evaluation of the relationship between T663A polymorphism in the alpha-epithelial sodium channel gene and essential hypertension. PMID: 26318459
Disorders of aldosterone synthesis, secretion, and cellular function. PMID: 24840884
Clinical and molecular features of type 1 pseudohypoaldosteronism. PMID: 19571553
Clinical implication of lung fluid balance in the perinatal period. PMID: 21448181
A novel approach to the functional classification of retinal ganglion cells. PMID: 35259949
Epithelial sodium channel, salt intake, and hypertension. PMID: 12530930
Scnn1 sodium channel gene family in genetically engineered mice. PMID: 11065344
A Unique Genotype of Pseudohypoaldosteronism Type 1b in a Highly Consanguineous Population. PMID: 34258491
Aldosterone deficiency with a hormone profile mimicking pseudohypoaldosteronism. PMID: 32809961
Salt-Losing Syndrome in a Girl with Type I and II Pseudohypoaldosteronism. PMID: 36303414
Effects of Sexual Experience and Puberty on Mouse Genital Cortex revealed by Chronic Imaging. PMID: 31630949
Phenotypic diversity and correlation with the genotypes of pseudohypoaldosteronism type 1. PMID: 31301676
Pharmacogenomics of diuretic drugs: data on rare monogenic disorders and on polymorphisms and requirements for further research. PMID: 14596636
Distinct local and brain-wide networks are activated by optogenetic stimulation of neurons specific to each layer of motor cortex. PMID: 36176220
Circuit Mechanisms Underlying Epileptogenesis in a Mouse Model of Focal Cortical Malformation. PMID: 33157021
Epigenetic profiles capturing breast cancer stemness for triple negative breast cancer control. PMID: 31729259
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC. PMID: 32452762
Errate: Salt-Losing Syndrome in a Girl with Type I and II Pseudohypoaldosteronism. PMID: 36789727
Clinical characteristics and treatment requirements of children with autosomal recessive pseudohypoaldosteronism. PMID: 33690157
All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds. PMID: 32229307
Bioinformatic Analysis for the Prognostic Implication of Genes Encoding Epithelial Sodium Channel in Cervical Cancer. PMID: 35210842
Human Urinary mRNA as a Biomarker of Cardiovascular Disease. PMID: 30354328
Chronic Systemic Dexamethasone Regulates the Mineralocorticoid/Glucocorticoid Pathways Balance in Rat Ocular Tissues. PMID: 35163201
Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice. PMID: 28539224
Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity. PMID: 23264685
Renomedullary Interstitial Cell Endothelin A Receptors Regulate BP and Renal Function. PMID: 32487560
Flexible Sensory Representations in Auditory Cortex Driven by Behavioral Relevance. PMID: 26586181
Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice. PMID: 34601973
Genetic interpretation and clinical translation of minor genes related to Brugada syndrome. PMID: 30821013
Layer-specific excitation/inhibition balances during neuronal synchronization in the visual cortex. PMID: 29313982
The epithelial sodium channel has a role in breast cancer cell proliferation. PMID: 33630195
Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting. PMID: 35462606
Lipid metabolism-related miRNAs with potential diagnostic roles in prostate cancer. PMID: 36915125
For research use only. Not for human or drug use.
