The RNASEL -1385G/A polymorphism is associated with risk of prostate cancer in Africans. PMID: 29317837
Human Melanoma Cells Differentially Express RNASEL/RNase-L and miR-146a-5p under Sex Hormonal Stimulation. PMID: 36286041
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children. PMID: 36538032
Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations? PMID: 29422015
RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients. PMID: 16537704
RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans. PMID: 18189233
Increase in RNASEL gene expression by miR-29-3p inhibitors in HEK293T cells. PMID: 33086852
RNASEL 1623A>C variant is associated with the risk of prostate cancer in African descendants. PMID: 30790337
Association between RNASEL, MSR1, and ELAC2 single nucleotide polymorphisms and gene expression in prostate cancer risk. PMID: 27318894
Genetic variation in RNASEL and risk for prostate cancer in a population-based case-control study. PMID: 21360564
Retraction. Identification of a novel gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PMID: 23028303
RNASEL and MIR146A SNP-SNP interaction as a susceptibility factor for non-melanoma skin cancer. PMID: 24699816
The OAS/RNaseL pathway and its inhibition by viruses. PMID: 33065920
Association of RNASEL variants with prostate cancer risk in Hispanic Caucasians and African Americans. PMID: 17908993
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. PMID: 33811184
RNASEL germline variants are associated with pancreatic cancer. PMID: 15981205
RNASEL mutations in hereditary prostate cancer. PMID: 12624150
Template-Independent Poly(A)-Tail Decay and RNASEL as Potential Cellular Biomarkers for Prostate Cancer Development. PMID: 35565367
Association of a common genetic variant in RNASEL and prostate cancer susceptibility. PMID: 29088852
Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases. PMID: 18767027
An alternative spliced RNASEL variant in peripheral blood leukocytes. PMID: 17115900
[RNASEL study of genetics of prostate cancer and its relation to clinical staging]. PMID: 22464196
RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases. PMID: 12641088
Carriage of mutations R462Q (rs 486907) and D541E (rs 627928) of the RNASEL gene and risk factors in patients with prostate cancer in Burkina Faso. PMID: 35655265
RNASEL gene polymorphisms and the risk of prostate cancer: a meta-analysis. PMID: 17020975
The RNASEL 471delAAAG allele and prostate cancer in Ashkenazi Jewish men. PMID: 12624151
RNASEL -1385G/A polymorphism and cancer risk: a meta-analysis based on 21 case-control studies. PMID: 21221811
Positive selection on the gene RNASEL: correlation between patterns of evolution and function. PMID: 22513284
Age-related methylation profiles of equine blood leukocytes in the RNASEL locus. PMID: 26553552
Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer. PMID: 14695991
Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes. PMID: 17822564
Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer. PMID: 18575592
PDE12 in type 1 diabetes. PMID: 36307540
Contribution of HPC1 (RNASEL) and HPCX variants to prostate cancer in a founder population. PMID: 20564318
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. PMID: 32497523
Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene. PMID: 15714208
RNASEL Asp541Glu and Arg462Gln polymorphisms in prostate cancer risk: evidences from a meta-analysis. PMID: 21656378
Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study. PMID: 16054567
Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer. PMID: 15330212
HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand. PMID: 15604285
Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer. PMID: 28654546
Short communication: RNASEL alleles and susceptibility to infection by human retroviruses and hepatitis viruses. PMID: 22356654
Restricting retrotransposons: a review. PMID: 27525044
Mapping of the human RNASEL promoter and expression in cancer and normal cells. PMID: 16241858
Genetic variation in RNASEL associated with prostate cancer risk and progression. PMID: 20576793
Association of RNASEL and 8q24 variants with the presence and aggressiveness of hereditary and sporadic prostate cancer in a Hispanic population. PMID: 24224612
The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides. PMID: 31276592
Predictive value in the analysis of RNASEL genotypes in relation to prostate cancer. PMID: 22083266
The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1. PMID: 17224235
Full activation of RNaseL in animal cells requires binding of 2-5A within ankyrin repeats 6 to 9 of this interferon-inducible enzyme. PMID: 10090396
DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland. PMID: 17627168
Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variants. PMID: 18289577
[Interferon]. PMID: 9309144
Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. PMID: 11941539
Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer. PMID: 15534086
Analysis of the RNASEL gene in familial and sporadic prostate cancer. PMID: 12022038
Evidence from 40 Studies that 2 Common Single-Nucleotide Polymorphisms (SNPs) of RNASEL Gene Affect Prostate Cancer Susceptibility: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-Compliant Meta-Analysis. PMID: 31686670
The IFN Response in Bats Displays Distinctive IFN-Stimulated Gene Expression Kinetics with Atypical RNASEL Induction. PMID: 29180486
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. PMID: 20086112
Can't RIDD off viruses. PMID: 24995003
Tetherin and its viral antagonists. PMID: 21222046
Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL. PMID: 26236721
Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population. PMID: 12915880
Immunogenetics of prostate cancer: a still unexplored field of study. PMID: 29325503
Analysis of the RNASEL/HPC1, and macrophage scavenger receptor 1 in Asian-Indian advanced prostate cancer. PMID: 18436282
OAS1, 2, and 3: Significance During Active Tuberculosis? PMID: 29452387
The 2,5 oligoadenylate synthetase/RNaseL pathway is a novel effector of BRCA1- and interferon-gamma-mediated apoptosis. PMID: 15940267
A single nucleotide polymorphism in inflammatory gene RNASEL predicts outcome after radiation therapy for localized prostate cancer. PMID: 23382116
Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality. PMID: 21846818
Association of susceptibility alleles in ELAC2/HPC2, RNASEL/HPC1, and MSR1 with prostate cancer severity in European American and African American men. PMID: 15824169
RNASEL Arg462Gln polymorphism and prostate cancer in PLCO. PMID: 17407163
Antagonism of Protein Kinase R by Large DNA Viruses. PMID: 35890034
Identification of cellular genes induced in human cells after activation of the OAS/RNaseL pathway by vaccinia virus recombinants expressing these antiviral enzymes. PMID: 20038200
A novel founder mutation in the RNASEL gene, 471delAAAG, is associated with prostate cancer in Ashkenazi Jews. PMID: 12641087
The 471delAAAG mutation and C353T polymorphism in the RNASEL gene in sporadic and inherited cancer in Israel. PMID: 16944274
Molecular biology in prostate cancer. PMID: 16648113
Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. PMID: 17234723
Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PMID: 16609730
Inflammation, infection, and prostate cancer. PMID: 18382242
Mechanistic insights into non-coding Y RNA processing. PMID: 35354369
Prevalent mutations in prostate cancer. PMID: 16267836
Molecular evolution of the prostate cancer susceptibility locus RNASEL: evidence for positive selection. PMID: 18295551
Interferon, Mx, and viral countermeasures. PMID: 17683972
The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response. PMID: 26760998
RNase-L Deficiency-Associated Intractable Indeterminate Colitis in Children. PMID: 31077295
Role of mitochondria in apoptosis induced by the 2-5A system and mechanisms involved. PMID: 16532271
Perspective: prostate cancer susceptibility genes. PMID: 12021166
Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation., PMID:38473966
Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice., PMID:37876532
Simultaneous Onset of Pediatric Systemic Lupus Erythematosus in Twin Brothers: Case Report., PMID:35783307
A specific promoter-type in ribonuclease L gene is associated with phagocytic activity in pigs., PMID:34321379
Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A., PMID:33445752
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug., PMID:30814222
Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity., PMID:30089512
A link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA., PMID:27831565
Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants., PMID:27334583
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon., PMID:26739051
Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling., PMID:23913960
Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells., PMID:21685539
No association of xenotropic murine leukemia virus-related viruses with prostate cancer., PMID:21573232
No evidence of XMRV in prostate cancer cohorts in the Midwestern United States., PMID:21447170
XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH., PMID:20371060
Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients., PMID:19835577
RNase L mediated protection from virus induced demyelination., PMID:19798426
[Anti-HIV effects of IFN-tau in human macrophages: role of cellular antiviral factors and interleukin-6]., PMID:18842358
The 2',5'-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells., PMID:16371364
Synthesis of novel siRNAs having thymidine dimers consisting of a carbamate or a urea linkage at their 3' overhang regions and their ability to suppress human RNase L protein expression., PMID:15823566
Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells., PMID:14585196
The quest for an efficacious antiviral for respiratory syncytial virus., PMID:12718405
Short interfering RNA confers intracellular antiviral immunity in human cells., PMID:12087357
Identification of a host protein essential for assembly of immature HIV-1 capsids., PMID:11780123
RNase L-independent specific 28S rRNA cleavage in murine coronavirus-infected cells., PMID:10982321
Characterization of RNABP, an RNA binding protein that associates with RNase L., PMID:10926206
Evidence for IRF-1-dependent gene expression deficiency in interferon unresponsive HepG2 cells., PMID:10446388
RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells., PMID:9660177
Lack of 2',5'-oligoadenylate-dependent RNase expression in the human hepatoma cell line HepG2., PMID:9561800
Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome., PMID:9243369
Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway., PMID:7539425
2-5A-dependent RNase molecules dimerize during activation by 2-5A., PMID:7876164
2',5'-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits., PMID:8463302
Polyclonal antibodies against RNase L. Subcellular localization of this enzyme in mouse cells., PMID:1706339
Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase., PMID:1705437
The epidermal growth factor- and interferon-independent effects of double-stranded RNA in A431 cells., PMID:2459591
A (2'-5')An-dependent endonuclease: tissue distribution in BALB/c mice and the effects of IFN-beta treatment and anti-IFN-alpha/beta immunoglobulin on the levels of the enzyme., PMID:3171245
The synergistic cytocidal effect produced by immune interferon and tumor necrosis factor in HT-29 cells is associated with inhibition of rRNA processing and (2',5') oligo (A) activation of RNase L., PMID:2451518
Antiviral activity in L1210 cells of liposome-encapsulated (2'-5')oligo(adenylate) analogues., PMID:2992962
Independent regulation of ppp(A2'p)nA-dependent RNase in NIH 3T3, clone 1 cells by growth arrest and interferon treatment., PMID:4019482
Expression of the 2-5A system during the cell cycle., PMID:4029267
Polyclonal antibody directed against 2-5A-dependent RNase., PMID:2421296
For research use only. Not for human or drug use.
