Hepatitis B x (HBx) as a Component of a Functional Cure for Chronic Hepatitis B. PMID: 36140311
Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx. PMID: 32987030
GPR43 regulates HBV X protein (HBx)-induced inflammatory response in human LO2 hepatocytes. PMID: 31884344
TRERNA1 upregulation mediated by HBx promotes sorafenib resistance and cell proliferation in HCC via targeting NRAS by sponging miR-22-3p. PMID: 33839325
Hepatitis B Virus X and Regulation of Viral Gene Expression. PMID: 26747833
Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis. PMID: 31170980
Potential of HBx Gene for Hepatocarcinogenesis in Noncirrhotic Liver. PMID: 33984871
MicroRNA-223 downregulation promotes HBx-induced podocyte pyroptosis by targeting the NLRP3 inflammasome. PMID: 35731327
HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis. PMID: 35784274
Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice. PMID: 21932402
Hepatitis B Virus-X Downregulates Expression of Selenium Binding Protein 1. PMID: 32443734
Hepatocellular carcinoma: The virus or the liver? PMID: 35319167
Hepatitis B virus X (HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase. PMID: 22562294
Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein. PMID: 32206612
HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. PMID: 36160029
HBx truncation mutants differentially modulate SREBP-1a and -1c transcription and HBV replication. PMID: 26191620
Hepatitis B Virus Protein X Induces Degradation of Talin-1. PMID: 27775586
Hepatitis B virus X (HBx) play an anti-apoptosis role in hepatic progenitor cells by activating Wnt/β-catenin pathway. PMID: 23934090
Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis. PMID: 23716588
HBx acts as an oncogene and promotes the invasion and metastasis of hepatocellular carcinoma both in vivo and vitro. PMID: 33153927
The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection. PMID: 21755567
HBx induces HepG-2 cells autophagy through PI3K/Akt-mTOR pathway. PMID: 23001846
Orexin A ameliorates HBV X protein-induced cytotoxicity and inflammatory response in human hepatocytes. PMID: 31106596
Expression of hepatitis B virus X (HBx) gene is up-regulated by adriamycin at the post-transcriptional level. PMID: 12207895
New strategies for the treatment of chronic hepatitis B. PMID: 35780008
Naringenin attenuates hepatitis B virus X protein-induced hepatic steatosis. PMID: 29183361
The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma. PMID: 35223517
Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication. PMID: 27626656
Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China. PMID: 22178505
HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism. PMID: 30975706
Hepatitis B virus-induced hepatocellular carcinoma: the role of the virus x protein. PMID: 24294951
Hepatitis B virus X gene impacts on the innate immunity and immune-tolerant phase in chronic hepatitis B virus infection. PMID: 35762289
Hepatitis B virus X reduces hepatocyte apoptosis and promotes cell cycle progression through the Akt/mTOR pathway in vivo. PMID: 30630095
[Effects of hepatitis B virus X protein on chronic hepatitis B pathophysiology]. PMID: 23245531
C-terminal-truncated HBV X promotes hepato-oncogenesis through inhibition of tumor-suppressive β-catenin/BAMBI signaling. PMID: 27909336
Ursolic Acid Suppresses Hepatitis B Virus X Protein-mediated Autophagy and Chemotherapeutic Drug Resistance. PMID: 27798869
HBx-induced hepatic steatosis and apoptosis are regulated by TNFR1- and NF-kappaB-dependent pathways. PMID: 20156456
Inactivation of tumor suppressor TAp63 by hepatitis B virus X protein in hepatocellular carcinoma. PMID: 35950770
Hepatitis B Virus X Protein Upregulates Intracellular Calcium Signaling by Binding C-terminal of Orail Protein. PMID: 30074148
Intracellular antibody targeting HBx suppresses invasion and metastasis in hepatitis B virus-related hepatocarcinogenesis via protein phosphatase 2A-B56γ-mediated dephosphorylation of protein kinase B. PMID: 35811356
HBx Regulation on HBV Pregenome Promoter in the Episomal Form Versus the Integrated Form. PMID: 37105923
[Role of histone demethylase KDM6B in HBx-mediated podocyte-macrophage transdifferentiation]. PMID: 33789369
Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs. PMID: 33397803
Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway. PMID: 26392315
Hepatocarcinogenesis in viral Hepatitis B infection: the role of HBx and p53. PMID: 16953033
High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein. PMID: 35137191
HBV Upregulates CtBP2 Expression via the X Gene. PMID: 30151388
Canonical and Divergent N-Terminal HBx Isoform Proteins Unveiled: Characteristics and Roles during HBV Replication. PMID: 34829930
Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patients. PMID: 34920100
Association between host TNF-α, TGF-β1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients. PMID: 31565220
HBV X gene point mutations are associated with the risk of hepatocellular carcinoma: A systematic review and meta-analysis. PMID: 27284442
Effect of the HBV whole-X gene on the expression of hepatocellular carcinoma associated proteins. PMID: 25311406
Hepatitis B virus (HBV) X gene diversity and evidence of recombination in HBV/HIV co-infected persons. PMID: 21520141
Compartmentalisation of Hepatitis B virus X gene evolution in hepatocellular carcinoma microenvironment and the genotype-phenotype correlation of tumorigenicity in HBV-related patients with hepatocellular carcinoma. PMID: 36102940
CA10 is associated with HBV-related hepatocarcinogenesis. PMID: 35800619
Correction to 'High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein'. PMID: 35212376
Expressions of HBV X gene regulated by different promoters and their effects on cell apoptosis. PMID: 30280771
Quantified integrated hepatitis B virus is related to viral activity in patients with chronic hepatitis B. PMID: 35073596
Retinoid X Receptor α-Dependent HBV Minichromosome Remodeling and Viral Replication. PMID: 28611266
E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation. PMID: 34097931
X region mutations of hepatitis B virus related to clinical severity. PMID: 27350725
NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression. PMID: 33767993
HBV X Protein Induces Degradation of UBXN7, a Novel Negative Regulator of NF-κB Signaling, to Promote HBV Replication. PMID: 36096451
The role of HBV-induced autophagy in HBV replication and HBV related-HCC. PMID: 29709654
Hepatitis B virus whole-X and X protein play distinct roles in HBV-related hepatocellular carcinoma progression. PMID: 27255760
Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes. PMID: 32145089
Hepatitis B Virus X Protein Function Requires Zinc Binding. PMID: 31167910
Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis. PMID: 26478665
Technical standards for hepatitis B virus X protein (HBx) research. PMID: 25099228
Hepatitis B virus X protein accelerates the development of hepatoma. PMID: 25364579
Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma. PMID: 28186085
Effects of HBV X gene and arsenic trioxide on the expression of p53 in cultured HepG2 cells. PMID: 18167198
Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication. PMID: 27529294
Analysis of HBV X gene quasispecies characteristics by next-generation sequencing and cloning-based sequencing and its association with hepatocellular carcinoma progression. PMID: 30712269
HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. PMID: 1827531
[Relationship between C genotype HBV mutation and intrauterine transmission]. PMID: 34814457
Long noncoding RNAs in hepatitis B virus replication and oncogenesis. PMID: 35978877
Hepatitis B virus X gene and hepatocarcinogenesis. PMID: 21647825
Hepatitis B Virus X Protein-Induced Serine Protease Inhibitor Kazal Type 1 Is Associated with the Progression of HBV-Related Diseases. PMID: 31240230
HBxAg promotes HBV replication and EGFR activation in human placental trophoblasts. PMID: 34584556
Interference of Apoptosis by Hepatitis B Virus. PMID: 28820498
Impact of hepatitis B virus (HBV) X gene integration in liver tissue on hepatocellular carcinoma development in serologically HBV-negative chronic hepatitis C patients. PMID: 18023912
The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection. PMID: 28095508
Hepatitis B virus X protein in the proliferation of hepatocellular carcinoma cells. PMID: 23747881
Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx. PMID: 29933745
[Hepatitis B virus (HBV) mutation in enhancer I (HBV Enh I)/X-promoter and the relationship between chronic HBV-related disease spectrum]. PMID: 22919746
[Association of human hepatitis B virus (HBV) X protein and hRPB5, a subunit of RNA polymerases, and X transactivation]. PMID: 12442364
Vitamin D signaling inhibits HBV activity by directly targeting the HBV core promoter. PMID: 34562448
Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. PMID: 21376091
X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy. PMID: 28986109
Hepatitis B virus X gene is implicated in liver carcinogenesis. PMID: 19464104
RPB5-Mediating Protein Suppresses Hepatitis B Virus (HBV) Transcription and Replication by Counteracting the Transcriptional Activation of Hepatitis B virus X Protein in HBV Replication Mouse Model. PMID: 26495109
Modulation of apoptotic signaling by the hepatitis B virus X protein. PMID: 23202511
For research use only. Not for human or drug use.
