Catalog No.
PHJ32901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human HTRA1 (Gly204-Leu364).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
High-temperature requirement A serine peptidase 1, Serine protease 11, HTRA1, PRSS11, HTRA, Serine protease HTRA1, L56
Purification
Purified by antigen affinity column.
Accession
Q92743
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration., PMID:40089174
A reliable clinical test for detection of membranous nephropathy antigens using laser microdissection and mass spectrometry., PMID:39197586
Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression., PMID:39028977
Genetics in neovascular age-related macular degeneration susceptibility and treatment response to anti-VEGF intravitreal injection: A case series study., PMID:38757252
Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform., PMID:38547109
Secretome from Magnetically Stimulated Muscle Exhibits Anticancer Potency: Novel Preconditioning Methodology Highlighting HTRA1 Action., PMID:38474424
Influence of Genetic Polymorphisms on the Short-Term Response to Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration., PMID:37862026
Exploring the Therapeutic Potential of Elastase Inhibition in Age-Related Macular Degeneration in Mouse and Human., PMID:37174708
The expanding spectrum and utility of antigens in membranous nephropathy., PMID:36811646
["New antigens" in membranous glomerulonephritis: let's take a closer look]., PMID:36563071
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration., PMID:36064790
Pediatric membranous nephropathy: In the novel antigens era., PMID:36016931
Hematopoietic Stem Cell Transplant-Membranous Nephropathy Is Associated with Protocadherin FAT1., PMID:35321939
Modulated anti-VEGF therapy under the influence of lipid metabolizing proteins in Age related macular degeneration: a pilot study., PMID:35027571
Phase 1 Study of the Anti-HtrA1 Antibody-binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-related Macular Degeneration., PMID:34214452
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy., PMID:33952630
Current Management and Therapeutic Strategies for Cerebral Amyloid Angiopathy., PMID:33918041
Identification of hub genes and key pathways in the emphysema phenotype of COPD., PMID:33535173
Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy., PMID:33297886
Genetic Variants Affecting Anti-VEGF Drug Response in Polypoidal Choroidal Vasculopathy Patients: A Systematic Review and Meta-Analysis., PMID:33198211
BETA-PERIPAPILLARY ATROPHY AND GEOGRAPHIC ATROPHY IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENTS TRIALS., PMID:32383840
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy., PMID:32345717
Incidence and Progression of Nongeographic Atrophy in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Clinical Trial., PMID:32191267
Loss of the serine protease HTRA1 impairs smooth muscle cells maturation., PMID:31796853
Protease Nexin I is a feedback regulator of EGF/PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness., PMID:31501409
HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression., PMID:31100080
Identification and tracking of problematic host cell proteins removed by a synthetic, highly functionalized nonwoven media in downstream bioprocessing of monoclonal antibodies., PMID:30898377
Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects., PMID:30795802
Immune response against HtrA proteases in children with cutaneous mastocytosis., PMID:30148508
High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling., PMID:29269789
A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration., PMID:28835685
HTRA1 and TGF-β1 Concentrations in the Aqueous Humor of Patients With Neovascular Age-Related Macular Degeneration., PMID:28114575
Blood biomarkers in a mouse model of CADASIL., PMID:27174004
The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody., PMID:26385991
Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B., PMID:26218915
Production, secretion and purification of a correctly folded staphylococcal antigen in Lactococcus lactis., PMID:26178240
Bevacizumab treatment for neovascular age-related macular degeneration in the setting of a clinic: "real life" long-term outcome., PMID:25881145
Pharmacogenomics of response to anti-VEGF therapy in exudative age-related macular degeneration., PMID:25635578
Pharmacogenetic associations with long-term response to anti-vascular endothelial growth factor treatment in neovascular AMD patients., PMID:25558172
Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials., PMID:25542520
Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities., PMID:25248123
Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice., PMID:25205867
Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related macular degeneration., PMID:25077532
Shark Attack: high affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation., PMID:24862193
Predictors of anti-VEGF treatment response in neovascular age-related macular degeneration., PMID:24332379
[Contemporary pharmacogenetic approaches to the treatment of age-related macular degeneration]., PMID:24261289
Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials., PMID:24084496
Genetic association with response to intravitreal ranibizumab for neovascular age-related macular degeneration in the Han Chinese population., PMID:24080590
Pharmacogenetics of the treatment response of age-related macular degeneration with ranibizumab and bevacizumab., PMID:24010796
Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression., PMID:23982886
For research use only. Not for human or drug use.
