Catalog No.
PHD05201
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human NCF1 (Met1-Val390).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
SH3PXD1A, NCF1, p47-phox, 47 kDa autosomal chronic granulomatous disease protein, Nox-organizing protein 2, NOXO2, SH3 and PX domain-containing protein 1A, NCF-1, 47 kDa neutrophil oxidase factor, NCF-47K, Nox organizer 2, Neutrophil NADPH oxidase factor 1, Neutrophil cytosol factor 1
Purification
Purified by antigen affinity column.
Accession
P14598
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Targeting S100A8/A9-NCF1 axis in tumor microenvironment to prevent tumor metastasis by self-assembled peptide nanofibers., PMID:40040282
The systemic lupus erythematosus-associated NCF190H allele synergizes with viral infection to cause mouse lupus but also limits virus spread., PMID:39939342
Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation., PMID:39931167
Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1+ monocytes-derived macrophages., PMID:39919902
The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis., PMID:39724988
Pathological and Biological Significance of the Specific Glycan, TRA-1-60, on Aggressive Gastric Adenocarcinoma., PMID:38718982
Recent topics and advanced therapies in chronic granulomatous disease., PMID:36534309
Adult case of chronic granulomatous disease mimicking granulomatosis with polyangiitis., PMID:36455104
Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst., PMID:35551534
Variants of beta-glucan polysaccharides downregulate autoimmune inflammation., PMID:35551269
Analysis of phagocytosis by mIgM+ lymphocytes depending on monoclonal antibodies against IgM of largemouth bass (Micropterus salmoides)., PMID:35314332
Genome-wide association studies for immunoglobulin concentrations in colostrum and serum in Chinese Holstein., PMID:35012443
Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice., PMID:34970267
Utility of Immunohistochemistry and Immunofluorescence in Determining the Pathogenic Variants of Chronic Granulomatous Disease., PMID:34651207
Human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages., PMID:34556485
Neutrophil-derived reactive oxygen species promote tumor colonization., PMID:34257370
Immune-related genes and gene sets for predicting the response to anti-programmed death 1 therapy in patients with primary or metastatic non-small cell lung cancer., PMID:34084219
Homozygous variant p. Arg90His in NCF1 is associated with early-onset Interferonopathy: a case report., PMID:33892719
p47phox deficiency improves cognitive impairment and attenuates tau hyperphosphorylation in mouse models of AD., PMID:33183342
Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population., PMID:31705128
NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus., PMID:31704719
NOX2 mediates quiescent handling of dead cell remnants in phagocytes., PMID:31349119
HMGB1 release from trophoblasts contributes to inflammation during Brucella melitensis infection., PMID:31265755
ATPR-induced differentiation and G0/G1 phase arrest in acute promyelocytic leukemia by repressing EBP50/NCF1 complex to promote the production of ROS., PMID:31254567
Tanshinone IIA inhibits lipopolysaccharide‑induced inflammatory responses through the TLR4/TAK1/NF‑κB signaling pathway in vascular smooth muscle cells., PMID:30816448
Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils., PMID:30323221
Inter-α inhibitor proteins maintain neutrophils in a resting state by regulating shape and reducing ROS production., PMID:30093530
The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models., PMID:29467756
Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase., PMID:29228045
The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation., PMID:27548433
Reactive Oxygen Species Regulate Innate But Not Adaptive Inflammation in ZAP70-Mutated SKG Arthritic Mice., PMID:27427418
Role of Flow Cytometry in the Diagnosis of Chronic Granulomatous Disease: the Egyptian Experience., PMID:27222152
Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells., PMID:26760964
Mechanism of p47phox-induced increase of reactive oxygen species in peripheral blood mononuclear cells from premature infants on oxygen therapy., PMID:26753753
[Diphenylene iodonium and apocynin reduce the translocation and level of p47phox in PBMCs of premature infants to inhibit reactive oxygen species production]., PMID:26728380
Alterations in the subcellular distribution of NADPH oxidase p47(phox) in hypothalamic paraventricular neurons following slow-pressor angiotensin II hypertension in female mice with accelerated ovarian failure., PMID:26659944
Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity., PMID:26553469
Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells., PMID:26514923
Neurotoxicity effects of atrazine-induced SH-SY5Y human dopaminergic neuroblastoma cells via microglial activation., PMID:26256823
Functional pseudogenes inhibit the superoxide production., PMID:26086043
B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production., PMID:25989352
Clinical application of whole-genome sequencing in patients with primary immunodeficiency., PMID:25981738
Metal-amplified Density Assays, (MADAs), including a Density-Linked Immunosorbent Assay (DeLISA)., PMID:25474561
Phagocyte NADPH oxidase restrains the inflammasome in ANCA-induced GN., PMID:25012177
Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47(phox) pathway., PMID:24967690
Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature., PMID:24787605
Evaluation of p47phox phosphorylation in human neutrophils using phospho-specific antibodies., PMID:24504966
A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement., PMID:23911657
Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells., PMID:23846495
Incomplete B cell tolerance to cartilage oligomeric matrix protein in mice., PMID:23754310
For research use only. Not for human or drug use.
