Catalog No.
PHG09201
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human APLP2 (Met1-Gly210).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
APPH, APLP-2, CDEBP, Amyloid protein homolog, CDEI box-binding protein, APLP2, APPL2, Amyloid-like protein 2
Purification
Purified by antigen affinity column.
Accession
Q06481
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain., PMID:36691315
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling., PMID:34526379
Improved Lysosomal Trafficking Can Modulate the Potency of Antibody Drug Conjugates., PMID:28151644
Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate., PMID:24898256
Amyloid precursor proteins are constituents of the presynaptic active zone., PMID:23815291
Characterization of proprotein convertase subtilisin/kexin type 9 (PCSK9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (APLP2)., PMID:23430252
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase., PMID:21695060
The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function., PMID:21445342
A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells., PMID:21325636
Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation., PMID:19808674
Amyloid precursor-like protein 2 association with HLA class I molecules., PMID:19184004
Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway., PMID:18717733
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1., PMID:18573216
The in vivo brain interactome of the amyloid precursor protein., PMID:17934213
YWK-II protein as a novel G(o)-coupled receptor for Müllerian inhibiting substance in cell survival., PMID:17452623
Differential distribution of Alzheimer's amyloid precursor protein family variants in human sperm., PMID:17405931
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP., PMID:15944124
[Advances in research on the target antigens of antisperm antibodies]., PMID:15267216
gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins., PMID:12779321
Identification and comparative analysis of differentially expressed proteins in rat striatum following 6-hydroxydopamine lesions of the nigrostriatal pathway: up-regulation of amyloid precursor-like protein 2 expression., PMID:12372026
feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping., PMID:11896189
Extracellular domain of YWK-II, a human sperm transmembrane protein, interacts with rat Müllerian-inhibiting substance., PMID:11373173
Evaluation of two sperm antigens, rSMP-B and YWK-II, as targets for immunocontraception., PMID:11358321
The amyloid precursor-like protein 2 associates with the major histocompatibility complex class I molecule K(d)., PMID:10652361
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains., PMID:9729270
A role for amyloid precursor-like protein 2 in corneal epithelial wound healing., PMID:9477985
Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease., PMID:9444352
Expression and distribution of amyloid precursor protein-like protein-2 in Alzheimer's disease and in normal brain., PMID:8863657
Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis., PMID:7472397
Expression of the amyloid protein precursor of Alzheimer's disease in the developing rat olfactory system., PMID:7493410
Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2., PMID:7616233
Human IMR-32 neuroblastoma cells as a model cell line in Alzheimer's disease research., PMID:7884825
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP)., PMID:8300594
Infertility induced in rats by immunization with synthetic peptide segments of a sperm protein., PMID:1550561
Expression of a gene encoding a specific human sperm protein in Chinese hamster ovarian cells., PMID:1520040
Characterization of cDNA encoding a human sperm membrane protein related to A4 amyloid protein., PMID:1690887
For research use only. Not for human or drug use.
