Anti-MAPKAPK2 Polyclonal Antibody

Catalog No.

PHE62701

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MAPKAPK2 (Glu139-Tyr367).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

MAPKAPK2, MAPKAP-K2, MAPKAP kinase 2, MAPKAPK-2, MAP kinase-activated protein kinase 2, MK2, MK-2, MAPK-activated protein kinase 2

Purification

Purified by antigen affinity column.

Accession

P49137

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Expression profile of mRNAs and miRNAs related to mitogen-activated kinases in HaCaT cell culture treated with lipopolysaccharide a and adalimumab., PMID:38557266

Development of cell-based high throughput luminescence assay for drug discovery in inhibiting OCT4/DNA-PKcs and OCT4-MK2 interactions., PMID:33565603

MYC transcription activation mediated by OCT4 as a mechanism of resistance to 13-cisRA-mediated differentiation in neuroblastoma., PMID:32409685

A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury., PMID:30483268

MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA., PMID:29770701

CMPD1 inhibited human gastric cancer cell proliferation by inducing apoptosis and G2/M cell cycle arrest., PMID:29661232

Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis., PMID:27492266

PO-45 - The role of microvesicles in multiple myeloma progression., PMID:27161734

Loss of Desmoglein Binding Is Not Sufficient for Keratinocyte Dissociation in Pemphigus., PMID:26288352

Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle., PMID:25851606

Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells., PMID:25542757

HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor., PMID:23996744

MAPKAP kinase 2 (MK2)-dependent and -independent models of blister formation in pemphigus vulgaris., PMID:23657501

Regulation of SPARC by transforming growth factor β2 in human trabecular meshwork., PMID:23513064

Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms., PMID:23139224

Childhood nephrotic syndrome--current and future therapies., PMID:22688744

DNA repair biomarkers predict response to neoadjuvant chemoradiotherapy in esophageal cancer., PMID:22000749

Identification and molecular characterization of a novel signaling molecule 14-3-3 epsilon in Clonorchis sinensis excretory/secretory products., PMID:21922237

Unfolded protein response signaling and MAP kinase pathways underlie pathogenesis of arsenic-induced cutaneous inflammation., PMID:21911445

The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migration., PMID:21297993

Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients., PMID:20805296

Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention., PMID:20713488

Adalimumab therapy rapidly inhibits p38 mitogen-activated protein kinase activity in lesional psoriatic skin preceding clinical improvement., PMID:20346019

Analysis of cochlear protein profiles of Wistar, Sprague-Dawley, and Fischer 344 rats with normal hearing function., PMID:19432484

SAGE analysis highlights the importance of p53csv, ddx5, mapkapk2 and ranbp2 to multiple myeloma tumorigenesis., PMID:19171422

Pertussis toxin induces angiogenesis in brain microvascular endothelial cells., PMID:18500752

Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex., PMID:17510053

MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization., PMID:17481585

Heat shock protein 1 and the mitogen-activated protein kinase 14 pathway are important for mouse trophoblast stem cell differentiation., PMID:17267699

CD23-mediated transport of IgE/immune complexes across human intestinal epithelium: role of p38 MAPK., PMID:16899715

CDC25B phosphorylation by p38 and MK-2., PMID:16861915

MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis., PMID:16849504

Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2., PMID:16424170

Nogo-B is a new physiological substrate for MAPKAP-K2., PMID:16095439

Mitogen-activated protein kinase (MAPK) blockade of bovine preimplantation embryogenesis requires inhibition of both p38 and extracellular signal-regulated kinase (ERK) pathways., PMID:15985630

p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development., PMID:15850458

MAP kinases in lung endothelial permeability induced by microtubule disassembly., PMID:15778245

Phosphorylation of p38 MAPK and its downstream targets in SARS coronavirus-infected cells., PMID:15194498

An Hsp27-related, dominant-negative-acting intracellular estradiol-binding protein., PMID:15123601

A unique model system for tumor progression in GBM comprising two developed human neuro-epithelial cell lines with differential transforming potential and coexpressing neuronal and glial markers., PMID:14965445

MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle., PMID:12799309

A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus., PMID:12699783

Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells., PMID:12490569

Requirement of c-Jun N terminal kinase and P38 mitogen-activated protein kinase for anti-IgM-induced reduction in mitochondrial membrane potential in CH31 B lymphoma cells., PMID:11852113

Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle., PMID:11579175

Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase., PMID:11490018

Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart., PMID:11448140

Differential translocation or phosphorylation of alpha B crystallin cannot be detected in ischemically preconditioned rabbit cardiomyocytes., PMID:10860771

Two distinct forms of MAPKAP kinase-2 in adult cardiac ventricular myocytes., PMID:10821688

Identification of a membrane Ig-induced p38 mitogen-activated protein kinase module that regulates cAMP response element binding protein phosphorylation and transcriptional activation in CH31 B cell lymphomas., PMID:10679065

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