Catalog No.
PHG45301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human MAP3K1 (Ile1307-Arg1509).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
MAPK/ERK kinase kinase 1, Mitogen-activated protein kinase kinase kinase 1, MAP3K1, MEKK 1, MEKK, MEK kinase 1, MAPKKK1, MEKK1
Purification
Purified by antigen affinity column.
Accession
Q13233
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Anti-complement 5 antibody ameliorates antibody-mediated rejection after liver transplantation in rats., PMID:37398677
Early Triple-Negative Breast Cancers in a Singapore Cohort Exhibit High PIK3CA Mutation Rates Associated With Low PD-L1 Expression., PMID:36788078
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
Integrated Transcriptomic and Epigenetic Study of PCOS: Impact of Map3k1 and Map1lc3a Promoter Methylation on Autophagy., PMID:33763111
Langerhans cell histiocytosis: A neoplastic disorder driven by Ras-ERK pathway mutations., PMID:29107340
Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials., PMID:29045529
Polymorphisms associated with etanercept response in moderate-to-severe plaque psoriasis., PMID:28470127
Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein., PMID:24422672
Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis., PMID:22109528
The IL-8 production by Streptococcal pyrogenic exotoxin B., PMID:19855073
Alpha-lipoic acid inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades., PMID:18182252
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production., PMID:17143273
A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing., PMID:16760432
RACK1 mediates activation of JNK by protein kinase C [corrected]., PMID:16061178
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis., PMID:15466206
Regulation of Gene33 expression by insulin requires MEK-ERK activation., PMID:15358516
Fcgamma receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction., PMID:14982949
Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells., PMID:14978732
Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer., PMID:14707447
Activation of endothelial extracellular signal-regulated kinase is essential for neutrophil transmigration: potential involvement of a soluble neutrophil factor in endothelial activation., PMID:14634124
Human intestinal epithelial crypt cell survival and death: Complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways., PMID:14603523
Distinct molecular pathways mediate progesterone-induced growth inhibition and focal adhesion., PMID:12970168
Rapamycin inhibits GM-CSF-induced neutrophil migration., PMID:12935893
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling., PMID:12876557
Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways., PMID:12796401
Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway., PMID:12763138
Involvement of calcium/calmodulin-dependent protein kinase II in the induction of mPer1., PMID:12692905
1alpha,25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a phosphatidylinositol 3-kinase/Ras/MEK/extracellular signal regulated kinase 1/2 and c-Jun N-terminal kinase 1-dependent increase in c-Fos, Fra1, and c-Jun expression in human keratinocytes., PMID:12648218
Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase., PMID:12587073
4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1., PMID:12391199
MEK inhibitor U0126 interferes with immunofluorescence analysis of apoptotic cell death., PMID:12210141
Inhibition of mitogen-activated protein kinase signaling by chloroquine., PMID:11994488
Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines., PMID:11992543
Convergence of signaling pathways on the activation of ERK in B cells., PMID:11976336
XK469, a novel antitumor agent, inhibits signaling by the MEK/MAPK signaling pathway., PMID:11914906
Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress., PMID:11879182
Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway., PMID:11859076
Macrophages inhibit Salmonella typhimurium replication through MEK/ERK kinase and phagocyte NADPH oxidase activities., PMID:11821396
[Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential]., PMID:11798872
Human intestinal epithelial cell survival: differentiation state-specific control mechanisms., PMID:11350749
Pharmacologic inhibitors of MKK1 and MKK2., PMID:11305115
A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2., PMID:11292831
Modulation of the basal activity of phosphatidylinositol-3-kinase/protein kinase B signaling pathway in human hepatocarcinoma cells., PMID:11261840
Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase., PMID:11242082
Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells., PMID:11160861
AKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domain., PMID:11133986
c-Jun NH2-terminal kinase activation leads to a FADD-dependent but Fas ligand-independent cell death in Jurkat T cells., PMID:11106658
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway., PMID:11099494
ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage., PMID:11056157
Pharmacological antagonism of tyrosine kinases and MAP kinase in brainstem blocks taste aversion learning in mice., PMID:10913789
For research use only. Not for human or drug use.
