Anti-Human SH2B3 Polyclonal Antibody

Catalog No.

PHJ83701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SH2B3 (Thr335-Ser561).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Lymphocyte-specific adapter protein Lnk, SH2B3, Signal transduction protein Lnk, LNK, Lymphocyte adapter protein, SH2B adapter protein 3

Purification

Purified by antigen affinity column.

Accession

Q9UQQ2

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Hematopoietic and eosinophil-specific LNK(SH2B3) deficiency promotes eosinophilia and arterial thrombosis., PMID:38096361

Autoimmune hepatitis presenting with concomitant chronic pancreatitis., PMID:37359250

CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients., PMID:36622793

Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study., PMID:36150053

Distinct blood protein profiles associated with the risk of short-term and mid/long-term clinical relapse in patients with Crohn's disease stopping infliximab: when the remission state hides different types of residual disease activity., PMID:36008101

Epigenetic Modifications in Placenta are Associated with the Child's Sensitization to Allergens., PMID:31111043

An Overview of Celiac Disease in Childhood Type 1 Diabetes., PMID:30214462

Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort., PMID:29310926

Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity., PMID:29018046

Presymptomatic Diagnosis of Celiac Disease in Predisposed Children: The Role of Gene Expression Profile., PMID:28827480

Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?, PMID:28520980

Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes., PMID:28438156

Association of established hypothyroidism-associated genetic variants with Hashimoto's thyroiditis., PMID:28382505

Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes., PMID:26405073

Transitioning from Idiopathic to Explainable Autoimmune Hepatitis., PMID:25999246

Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?, PMID:25979711

Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study., PMID:25422107

The association of thyroid peroxidase antibody risk loci with susceptibility to and phenotype of Graves' disease., PMID:25345847

A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion., PMID:24249616

Thrombotic antiphospholipid syndrome shows strong haplotypic association with SH2B3-ATXN2 locus., PMID:23844121

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children., PMID:23539116

Genetic analysis of adult-onset autoimmune diabetes., PMID:21873553

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases., PMID:21829393

Gene transfer of the adaptor Lnk (SH2B3) prevents porcine endothelial cell activation and apoptosis: implication for xenograft's cytoprotection., PMID:21496118

The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients., PMID:20546165

Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis., PMID:19951419

Transcriptional up-regulation of the signaling regulatory protein LNK in activated endothelial cells., PMID:12451278

Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein., PMID:11163396

Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase., PMID:8524815

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