Catalog No.
PHC82301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CYP2D6 (Leu236-Gln472).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Debrisoquine 4-hydroxylase, CYP2DL1, Cytochrome P450 2D6, Cytochrome P450-DB1, CYPIID6, Cholesterol 25-hydroxylase, CYP2D6
Purification
Purified by antigen affinity column.
Accession
P10635
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Evaluation of the Effect of Risankizumab on the Pharmacokinetics of Cytochrome P450 Substrates in Patients with Moderately to Severely Active Ulcerative Colitis or Crohn's Disease., PMID:39707077
Protective effects of YCHD on the autoimmune hepatitis mice model induced by Ad-CYP2D6 through modulating the Th1/Treg ratio and intestinal flora., PMID:39606230
Genetic susceptibility and clinical features of CYP2D6 associated with systemic lupus erythematosus in a Chinese population., PMID:39287122
The Black Book of Psychotropic Dosing and Monitoring., PMID:38993656
Identification of ADME genes polymorphic variants linked to trastuzumab-induced cardiotoxicity in breast cancer patients: Case series of mono-institutional experience., PMID:38547766
Type 2 autoimmune hepatitis: Genetic susceptibility., PMID:36248826
Development of a New Murine Model of Type 2 Autoimmune Hepatitis Using a Human Liver Protein., PMID:34717895
Autoimmmune hepatitis., PMID:34580437
Concomitant occurence of multiple autoantibodies against human cytochromes P450., PMID:34464888
Regulatory T Cells in Autoimmune Hepatitis: Unveiling Their Roles in Mouse Models and Patients., PMID:33117375
MATERNAL GRAVES DISEASE AND ABNORMAL CYP2D6 GENOTYPE WITH FETAL HYPERTHYROIDISM., PMID:32671217
Evaluating Potential Disease-Mediated Protein-Drug Interactions in Patients With Moderate-to-Severe Plaque Psoriasis Receiving Subcutaneous Guselkumab., PMID:32407591
A comprehensive analysis of antigen-specific autoimmune liver disease related autoantibodies in patients with multiple sclerosis., PMID:32308974
Novel Insights into Plasmodium vivax Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence., PMID:32122891
Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model., PMID:31906950
Effects of adenovirus-induced hepatocyte damage on chronic bile duct inflammation in a sclerosing cholangitis mouse model., PMID:31225929
Physicochemical Properties, Biotransformation, and Transport Pathways of Established and Newly Approved Medications: A Systematic Review of the Top 200 Most Prescribed Drugs vs. the FDA-Approved Drugs Between 2005 and 2016., PMID:30972694
Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification., PMID:30930421
Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6., PMID:30596462
Lack of Effect of 12-Week Treatment with Risankizumab on the Pharmacokinetics of Cytochrome P450 Probe Substrates in Patients with Moderate to Severe Chronic Plaque Psoriasis., PMID:30574672
[Establishment of a mouse model of autoimmune hepatitis induced by human CYP2D6]., PMID:30384866
CYP2J2 is the major enzyme in human liver microsomes responsible for hydroxylation of SYL-927, a novel and selective sphingosine 1-phosphate receptor 1 (S1P1 ) agonist., PMID:30362120
Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl., PMID:29963210
Effect of single-walled carbon nanotubes on cytochrome P450 activity in human liver microsomes in vitro., PMID:29719052
Autoantibodies in Autoimmune Hepatitis: Can Epitopes Tell Us about the Etiology of the Disease?, PMID:29503645
Evaluation of Potential Disease-Mediated Drug-Drug Interaction in Patients With Moderate-to-Severe Atopic Dermatitis Receiving Dupilumab., PMID:29498038
Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells., PMID:28615694
Molecular and immunological analyses of confirmed Plasmodium vivax relapse episodes., PMID:28558712
Correlations of CYP2C9*3/CYP2D6*10/CYP3A5*3 gene polymorphisms with efficacy of etanercept treatment for patients with ankylosing spondylitis: A case-control study., PMID:28248857
The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development., PMID:27974250
Metabolic characterization of (1-(5-fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)-methanone (MAM-2201) using human liver microsomes and cDNA-overexpressed cytochrome P450 enzymes., PMID:27924364
Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?, PMID:27916939
Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol., PMID:27836712
The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model., PMID:27414259
Therapeutic protein-drug interaction assessment for daclizumab high-yield process in patients with multiple sclerosis using a cocktail approach., PMID:26991517
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model., PMID:26924542
CYP450 Enzyme-Mediated Metabolism of TCAS and Its Inhibitory and Induced Effects on Metabolized Enzymes in Vitro., PMID:26404338
A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation., PMID:26185095
Transitioning from Idiopathic to Explainable Autoimmune Hepatitis., PMID:25999246
Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking., PMID:25872594
Functional characterization of CYP2D6 enhancer polymorphisms., PMID:25381333
The role of vitamin d in autoimmune hepatitis., PMID:24171052
In vitro identification of cytochrome P450 enzymes responsible for drug metabolism., PMID:23824861
Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6., PMID:23809878
Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries., PMID:23758476
Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis., PMID:23200317
Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies., PMID:23165723
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection., PMID:22762141
In vitro characterization of the drug-drug interaction potential of catabolites of antibody-maytansinoid conjugates., PMID:22752008
Functional characterization of a first avian cytochrome P450 of the CYP2D subfamily (CYP2D49)., PMID:22675558
For research use only. Not for human or drug use.
