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Anti-CRYAB Polyclonal Antibody

Catalog #:   PHB97901 Specific References (49) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P02511
Overview

Catalog No.

PHB97901

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CRYAB (Met1-Lys175).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Rosenthal fiber component, CRYA2, HspB5, Alpha-crystallin B chain, HSPB5, Heat shock protein beta-5, Alpha(B)-crystallin, CRYAB, Renal carcinoma antigen NY-REN-27

Purification

Purified by antigen affinity column.

Accession

P02511

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • Western Blot
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with CRYAB antibody (PHB97901) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 22 kDa
    Observed MW: 22 kDa
References

Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline beta., PMID:40372913

Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease., PMID:40122840

Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls., PMID:40063790

Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta., PMID:39763959

In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis., PMID:39742283

Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson's disease reveals unique and shared pathological features., PMID:39345456

Enhanced and cross-reactive in vitro memory B cell response against Epstein-Barr virus nuclear antigen 1 in multiple sclerosis., PMID:39257578

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis., PMID:37196088

Alpinumisoflavone ameliorates choroidal neovascularisation and fibrosis in age-related macular degeneration in in vitro and in vivo models., PMID:35995845

Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies., PMID:35302338

Cluster analyses of the TCGA and a TMA dataset using the coexpression of HSP27 and CRYAB improves alignment with clinical-pathological parameters of breast cancer and suggests different epichaperome influences for each sHSP., PMID:35235182

FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress., PMID:34239032

The engineered expression of secreted HSPB5-Fc in CHO cells exhibits cytoprotection in vitro., PMID:34126963

A novel metastatic promoter CEMIP and its downstream molecular targets and signaling pathway of cellular migration and invasion in SCLC cells based on proteome analysis., PMID:32648226

Targeting of externalized αB-crystallin on irradiated endothelial cells with pro-thrombotic vascular targeting agents: Potential applications for brain arteriovenous malformations., PMID:32208214

Quantification of biomarkers for beef meat qualities using a combination of Parallel Reaction Monitoring- and antibody-based proteomics., PMID:32078991

Radiation-Stimulated Translocation of CD166 and CRYAB to the Endothelial Surface Provides Potential Vascular Targets on Irradiated Brain Arteriovenous Malformations., PMID:31757032

Autoimmune-Mediated Retinopathy in CXCR5-Deficient Mice as the Result of Age-Related Macular Degeneration Associated Proteins Accumulation., PMID:31474986

The early response of αB-crystallin to a single bout of aerobic exercise in mouse skeletal muscles depends upon fiber oxidative features., PMID:30974319

Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells., PMID:30463298

Autoantibody profiling reveals four protein candidate autoantigens associated with systemic lupus erythematosus., PMID:30041579

Wnt5a Contributes to the Differentiation of Human Embryonic Stem Cells into Lentoid Bodies Through the Noncanonical Wnt/JNK Signaling Pathway., PMID:30025083

Small heat shock protein speciation: novel non-canonical 44 kDa HspB5-related protein species in rat and human tissues., PMID:29542021

A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family., PMID:28546921

Heat shock factor 4 regulates lens epithelial cell homeostasis by working with lysosome and anti-apoptosis pathways., PMID:27586257

Heat shock factor 1 induces crystallin-αB to protect against cisplatin nephrotoxicity., PMID:27194715

Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines., PMID:26010766

Carbonic anhydrase 4 and crystallin α-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology., PMID:24880201

Comparative analysis of αB-crystallin expression in heat-stressed myocardial cells in vivo and in vitro., PMID:24466295

Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68., PMID:23586607

Is alpha-B crystallin an independent marker for prognosis in lung cancer?, PMID:23582651

O-GlcNAcylation of αB-crystallin regulates its stress-induced translocation and cytoprotection., PMID:23543138

Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization., PMID:23395094

The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis., PMID:23055712

Human anterior lens capsule serving as a substrate for human trabecular meshwork cells cultivation., PMID:22836959

CRYAB-650 C>G (rs2234702) affects susceptibility to Type 1 diabetes and IAA-positivity in Swedish population., PMID:22537749

Epstein-Barr virus and multiple sclerosis., PMID:21836034

Localization of a wide-ranging panel of antigens in the rat retina by immunohistochemistry: comparison of Davidson's solution and formalin as fixatives., PMID:21832149

Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches., PMID:21474795

Infantile muscular dystrophy in Canadian aboriginals is an αB-crystallinopathy., PMID:21337604

Alphab-crystallin is a target for adaptive immune responses and a trigger of innate responses in preactive multiple sclerosis lesions., PMID:20535035

In-frame deletion in the seventh immunoglobulin-like repeat of filamin C in a family with myofibrillar myopathy., PMID:19050726

High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function., PMID:18793185

Contraction in human myometrium is associated with changes in small heat shock proteins., PMID:17916631

Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination., PMID:17568699

Interruption of CryAB-amyloid oligomer formation by HSP22., PMID:17092938

Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects., PMID:16376610

[Familial myopathy with desmin storage seen as a granulo-filamentar, electron-dense material without mutation of the alphabeta-crystallin gene]., PMID:11412718

Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain., PMID:2539261

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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Anti-CRYAB Polyclonal Antibody [PHB97901]
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