Catalog No.
PHB97901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CRYAB (Met1-Lys175).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Rosenthal fiber component, CRYA2, HspB5, Alpha-crystallin B chain, HSPB5, Heat shock protein beta-5, Alpha(B)-crystallin, CRYAB, Renal carcinoma antigen NY-REN-27
Purification
Purified by antigen affinity column.
Accession
P02511
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline beta., PMID:40372913
Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease., PMID:40122840
Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls., PMID:40063790
Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta., PMID:39763959
In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis., PMID:39742283
Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson's disease reveals unique and shared pathological features., PMID:39345456
Enhanced and cross-reactive in vitro memory B cell response against Epstein-Barr virus nuclear antigen 1 in multiple sclerosis., PMID:39257578
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis., PMID:37196088
Alpinumisoflavone ameliorates choroidal neovascularisation and fibrosis in age-related macular degeneration in in vitro and in vivo models., PMID:35995845
Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies., PMID:35302338
Cluster analyses of the TCGA and a TMA dataset using the coexpression of HSP27 and CRYAB improves alignment with clinical-pathological parameters of breast cancer and suggests different epichaperome influences for each sHSP., PMID:35235182
FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress., PMID:34239032
The engineered expression of secreted HSPB5-Fc in CHO cells exhibits cytoprotection in vitro., PMID:34126963
A novel metastatic promoter CEMIP and its downstream molecular targets and signaling pathway of cellular migration and invasion in SCLC cells based on proteome analysis., PMID:32648226
Targeting of externalized αB-crystallin on irradiated endothelial cells with pro-thrombotic vascular targeting agents: Potential applications for brain arteriovenous malformations., PMID:32208214
Quantification of biomarkers for beef meat qualities using a combination of Parallel Reaction Monitoring- and antibody-based proteomics., PMID:32078991
Radiation-Stimulated Translocation of CD166 and CRYAB to the Endothelial Surface Provides Potential Vascular Targets on Irradiated Brain Arteriovenous Malformations., PMID:31757032
Autoimmune-Mediated Retinopathy in CXCR5-Deficient Mice as the Result of Age-Related Macular Degeneration Associated Proteins Accumulation., PMID:31474986
The early response of αB-crystallin to a single bout of aerobic exercise in mouse skeletal muscles depends upon fiber oxidative features., PMID:30974319
Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells., PMID:30463298
Autoantibody profiling reveals four protein candidate autoantigens associated with systemic lupus erythematosus., PMID:30041579
Wnt5a Contributes to the Differentiation of Human Embryonic Stem Cells into Lentoid Bodies Through the Noncanonical Wnt/JNK Signaling Pathway., PMID:30025083
Small heat shock protein speciation: novel non-canonical 44 kDa HspB5-related protein species in rat and human tissues., PMID:29542021
A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family., PMID:28546921
Heat shock factor 4 regulates lens epithelial cell homeostasis by working with lysosome and anti-apoptosis pathways., PMID:27586257
Heat shock factor 1 induces crystallin-αB to protect against cisplatin nephrotoxicity., PMID:27194715
Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines., PMID:26010766
Carbonic anhydrase 4 and crystallin α-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology., PMID:24880201
Comparative analysis of αB-crystallin expression in heat-stressed myocardial cells in vivo and in vitro., PMID:24466295
Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68., PMID:23586607
Is alpha-B crystallin an independent marker for prognosis in lung cancer?, PMID:23582651
O-GlcNAcylation of αB-crystallin regulates its stress-induced translocation and cytoprotection., PMID:23543138
Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization., PMID:23395094
The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis., PMID:23055712
Human anterior lens capsule serving as a substrate for human trabecular meshwork cells cultivation., PMID:22836959
CRYAB-650 C>G (rs2234702) affects susceptibility to Type 1 diabetes and IAA-positivity in Swedish population., PMID:22537749
Epstein-Barr virus and multiple sclerosis., PMID:21836034
Localization of a wide-ranging panel of antigens in the rat retina by immunohistochemistry: comparison of Davidson's solution and formalin as fixatives., PMID:21832149
Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches., PMID:21474795
Infantile muscular dystrophy in Canadian aboriginals is an αB-crystallinopathy., PMID:21337604
Alphab-crystallin is a target for adaptive immune responses and a trigger of innate responses in preactive multiple sclerosis lesions., PMID:20535035
In-frame deletion in the seventh immunoglobulin-like repeat of filamin C in a family with myofibrillar myopathy., PMID:19050726
High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function., PMID:18793185
Contraction in human myometrium is associated with changes in small heat shock proteins., PMID:17916631
Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination., PMID:17568699
Interruption of CryAB-amyloid oligomer formation by HSP22., PMID:17092938
Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects., PMID:16376610
[Familial myopathy with desmin storage seen as a granulo-filamentar, electron-dense material without mutation of the alphabeta-crystallin gene]., PMID:11412718
Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain., PMID:2539261
For research use only. Not for human or drug use.
