Catalog No.
YHG57501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu163
Predicted molecular weight
45.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13526
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, 5.2.1.8, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, Rotamase Pin1, PIN1
A suppressor screen of an Arabidopsis thaliana REDUCED COMPLEXITY (RCO)-expressing strain provides insight into the genetics of leaf margin complexity., PMID:40512673
PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma., PMID:40478452
Biological characteristics of spontaneous ovarian cancer in Microtusfortis., PMID:40457786
Adaptor protein-2 regulate root cell division and differentiation in Arabidopsis thaliana., PMID:40393619
A tethering mechanism underlies Pin1-catalyzed proline cis-trans isomerization at a noncanonical site., PMID:40388619
From root to embryogenic transition: WOX5 reprograms plant somatic cells via auxin-mediated pathways., PMID:40375128
Homocysteine Mediates Cognitive Inflexibility Induced by Stress via Targeting PIN1., PMID:40309848
Scaffold Hopping and Optimization of Thiazole Hybrids as Selective PIN1 Inhibitors: A Computational Study., PMID:40265424
HEX-1 reduces colitis-driven colorectal cancer via inactivating the prolyl isomerase PIN1 sensitization and remodeling the gut microbiota., PMID:40251462
PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance., PMID:40229270
The PIN1-p38-CtIP signalling axis protects stalled replication forks from deleterious degradation., PMID:40207632
Erratum: Non-canonical Function of Prolyl Hydroxylase Domain 2 in Breast Cancer Cell Growth and Progression: Role of Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1., PMID:40201030
Design and synthesis of a clickable cell-permeable pseudopeptide Pin1 inhibitor with antiproliferative effects on human multiple myeloma cell line., PMID:40125575
GraphBAN: An inductive graph-based approach for enhanced prediction of compound-protein interactions., PMID:40102386
Identification and inhibition of PIN1-NRF2 protein-protein interactions through computational and biophysical approaches., PMID:40087364
Mathematical analysis of long-distance polar auxin transport data of pin mutants questions the role of PIN1 as postulated in the chemi-osmotic theory., PMID:40079179
E3 ligase MIB1 regulates STAT1/P21 signaling via regulation of FGFR1 in colorectal cancer., PMID:40063182
Maximum Likelihood Analysis of Diffusing Molecules with Conformational Dynamics in Single-Molecule FRET., PMID:39965193
Effects of D-Amino Acid Replacements on the Conformational Stability of Miniproteins., PMID:39948034
Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)., PMID:39886975
Structure-Guided Optimization and Preclinical Evaluation of 6-O-Benzylguanine-Based Pin1 Inhibitor for Hepatocellular Carcinoma Treatment., PMID:39868498
OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth., PMID:39862868
Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia., PMID:39857613
Discovery of Novel Pyrimidine Derivatives as Human Pin1 Covalent Inhibitors., PMID:39811131
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway., PMID:39808064
Non-canonical Function of Prolyl Hydroxylase Domain 2 in Breast Cancer Cell Growth and Progression: Role of Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1., PMID:39790223
USP34 regulates PIN1-cGAS-STING axis-dependent ferroptosis in cervical cancer via SUMOylation., PMID:39752760
A comprehensive investigation of the impact of cross-linker backbone structure on protein dynamics analysis: A case study with Pin1., PMID:39736203
The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis., PMID:39724988
Correction for Alboreggia et al., Targeted degradation of Pin1 by protein-destabilizing compounds., PMID:39705324
The mechanisms of Pin1 as targets for cancer therapy., PMID:39624096
Exosome-based strategy against colon cancer using small interfering RNA-loaded vesicles targeting soluble a proliferation-inducing ligand., PMID:39619877
Overexpression of PIN1 in patients with severe COVID-19., PMID:39616688
Pin1 promotes human CaV2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2., PMID:39609819
A structure-based approach to discover a potential isomerase Pin1 inhibitor for cancer therapy using computational simulation and biological studies., PMID:39586226
KNUCKLES regulates floral meristem termination by controlling auxin distribution and cytokinin activity., PMID:39576002
PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein., PMID:39536935
Targeted degradation of Pin1 by protein-destabilizing compounds., PMID:39531501
Overexpression of Pin1 regulated by TOP2A, which subsequently stabilizes Pyk2 to promote bortezomib resistance in multiple myeloma., PMID:39511416
Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease., PMID:39469929
PEP-1-PIN1 Promotes Hippocampal Neuronal Cell Survival by Inhibiting Cellular ROS and MAPK Phosphorylation., PMID:39457664
Small peptide SiDVL/RTFLs from foxtail millet inhibit root growth through repressing auxin signaling in transgenic Arabidopsis., PMID:39433684
Pin1: Advances in pancreatic cancer therapeutic potential and inhibitors research., PMID:39418844
Transport properties of canonical PIN-FORMED proteins from Arabidopsis and the role of the loop domain in auxin transport., PMID:39413780
Pelargonic acid's interaction with the auxin transporter PIN1: A potential mechanism behind its phytotoxic effects on plant metabolism., PMID:39395675
Achieving a 35-Plex Tandem Mass Tag Reagent Set through Deuterium Incorporation., PMID:39380184
Pin1 WW Domain Ligand Library Synthesized with an Easy Solid-Phase Phosphorylating Reagent., PMID:39377814
Amentoflavone Induces Ferroptosis to Alleviate Proliferation, Migration, Invasion and Inflammation in Rheumatoid Arthritis Fibroblast-like Synoviocytes by Inhibiting PIN1., PMID:39354278
Identification of potential new T cell activation molecules: a Bioinformatic Approach., PMID:39333573
Gallic acid regulates primary root elongation via modulating auxin transport and signal transduction., PMID:39286841
For research use only. Not for human or drug use.
