Catalog No.
YHD08801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe316
Predicted molecular weight
38.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P15121
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Aldo-keto reductase family 1 member B1, 1.1.1.300, 1.1.1.372, 1.1.1.54, Aldehyde reductase, Aldose reductase, AR, 1.1.1.21, AKR1B1, ALDR1, ALR2
Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase., PMID:40487600
AKR1B1 Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic Significance., PMID:40396420
The Role of Claudin-1 in Enhancing Pancreatic Cancer Aggressiveness and Drug Resistance via Metabolic Pathway Modulation., PMID:40361399
The NFE2L2 (NRF2) transcription factor controls genes involved in the oxidative stress response and inflammation in myometrial cells., PMID:40360022
In silico characterization of the interaction of AKR1B1 with the deacetylase activation domain (DAD)., PMID:40309007
Investigation of new autoantibodies in urothelial bladder cancer for biomarker discovery using immunoproteomics., PMID:40163213
A New Histology-Based Prognostic Index for Acute Myeloid Leukemia: Preliminary Results for the "AML Urayasu Classification"., PMID:40142797
The causal effects of 2,821 protein level ratios on non-small cell lung cancer: a two-sample Mendelian randomization study., PMID:40104726
Impact of intermittent high-dose radon exposures on lung epithelial cells: proteomic analysis and biomarker identification., PMID:40088196
Identification of Known Flavonoids of Ficus carica L. as Aldose Reductase Inhibitors in Sciatic Nerve of Diabetic Neuropathy-induced Rats through Bioinformatics and Proteomics Analysis., PMID:40070327
AKR1B1 Inhibits Ferroptosis and Promotes Gastric Cancer Progression via Interacting With STAT3 to Activate SLC7A11., PMID:39911124
Placental Proteomics Reveals an Elevated Level of Aldo-Keto Reductase 1-B1, Highlighting Its Potential Role in Spontaneous Preterm Birth., PMID:39762117
Exploration and validation of a novel reactive oxygen species-related signature for predicting the prognosis and chemotherapy response of patients with bladder cancer., PMID:39749345
Unveiling the substantial role of rutin in the management of drug-induced nephropathy using network pharmacology and molecular docking., PMID:39733639
Analysis of synthetic polymer hydrogel-based generation of leukemia stem cells., PMID:39700762
Exploration of leads from bis-indole based triazine derivatives targeting human aldose reductase in diabetic type 2: in-silico approaches., PMID:39676892
Isolation of phytoconstituents from an extract of Murraya paniculata with cytotoxicity and antioxidant activities and in silico evaluation of their potential to bind to aldose reductase (AKR1B1)., PMID:39636240
Comparative proteomic analysis of human vitreous in rhegmatogenous retinal detachment and diabetic retinopathy reveals a common pathway and potential therapeutic target., PMID:39609746
Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer., PMID:39567724
Association between the rs1800624 and rs80096349 SNPs and diabetic retinopathy: a pilot study., PMID:39539063
Exploring the key pathogenic mechanisms and potential intervention targets for Sophorae Flavescentis radix in managing bone metastasis of lung cancer based on network pharmacology and molecular docking techniques., PMID:39524998
Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer., PMID:39406919
AKR1B1-dependent fructose metabolism enhances malignancy of cancer cells., PMID:39406918
The challenging inhibition of Aldose Reductase for the treatment of diabetic complications: a 2019-2023 update of the patent literature., PMID:39365044
Sanger Sequencing Reveals Novel Variants in GLO-1, ACE, and CBR1 Genes in Patients of Early and Severe Diabetic Nephropathy., PMID:39336582
Overexpression of SLC2A1, ALDOC, and PFKFB4 in the glycolysis pathway drives strong drug resistance in 3D HeLa tumor cell spheroids., PMID:39295558
The Anti-Hypoxic Mechanism of Sesamoside Determined Using Network Pharmacology., PMID:39253070
NRF2 inhibits RSL3 induced ferroptosis in gastric cancer through regulation of AKR1B1., PMID:39154929
Exploring the mechanism of Pueraria lobata (Willd.) Ohwi in the regulation of obesity., PMID:39154668
Applying Network Pharmacology and Molecular Docking in the Screening for Molecular Mechanisms of Ampalaya (Momordica charantia L.) and Banaba (Lagerstroemia speciosa L.) against Type 2 Diabetes Mellitus., PMID:38812760
SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis., PMID:38776924
Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Gene Analysis., PMID:38618724
Network pharmacology combined with molecular docking and dynamics to assess the synergism of esculetin and phloretin against acute kidney injury-diabetes comorbidity., PMID:38578376
Metabolic pathways for glucose and fructose: I synthesis and metabolism of fructose by ovine conceptuses†., PMID:38501845
Decoding selectivity: computational insights into AKR1B1 and AKR1B10 inhibition., PMID:38469695
C-C motif chemokine ligand 2 regulates prostaglandin synthesis and embryo attachment of the bovine endometrium during implantation., PMID:38438567
Effects of commonly used carbamates (carbaryl and thiram) on the regulatory, secretory and motor functions of bovine cervixes in vitro., PMID:38330862
EPS15-AS1 Inhibits AKR1B1 Expression to Enhance Ferroptosis in Hepatocellular Carcinoma Cells., PMID:38230218
The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer., PMID:38200154
Proteomics-based screening of AKR1B1 as a therapeutic target and validation study for sepsis-associated acute kidney injury., PMID:38188141
In vitro evaluation of the reductive carbonyl idarubicin metabolism to evaluate inhibitors of the formation of cardiotoxic idarubicinol via carbonyl and aldo-keto reductases., PMID:38175295
Network pharmacology combines machine learning, molecular simulation dynamics and experimental validation to explore the mechanism of acetylbinankadsurin A in the treatment of liver fibrosis., PMID:38169205
Endogenous reductase activities for the generation of ribitol-phosphate, a CDP-ribitol precursor, in mammals., PMID:38140954
Differential metabolites screening in yak (Bos grunniens) seminal plasma after cryopreservation and the evaluation of the effect of galactose on post-thaw sperm motility., PMID:38103402
Exploration of the Mechanism of Kaempferol in the Treatment of Cervical Cancer-based on Metabolomics and Network Pharmacology., PMID:38062663
Metabolic Pathways for Removing Reactive Aldehydes are Diminished in Atrophic Muscle During Heart Failure., PMID:38045249
Trans-(±)-TTPG-B Attenuates Cell Cycle Progression and Inhibits Cell Proliferation on Cholangiocarcinoma Cells., PMID:37959760
Repurposing of Strychnine as the Potential Inhibitors of Aldo-keto Reductase Family 1 Members B1 and B10: Computational Modeling and Pharmacokinetic Analysis., PMID:37940790
Del Nido cardioplegia or potassium induces Nrf2 and protects cardiomyocytes against oxidative stress., PMID:37842750
Effects of 17β-estradiol on the uterine luteolytic cascade in bovine females at the end of diestrus., PMID:37783065
For research use only. Not for human or drug use.
