Catalog No.
YHD05001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Tyr325
Predicted molecular weight
38.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P14550
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Aldo-keto reductase family 1 member A1, 1.1.1.2, 1.1.1.372, 1.1.1.54, Alcohol dehydrogenase [NADP(+)], Aldehyde reductase, Glucuronate reductase, 1.1.1.19, Glucuronolactone reductase, 1.1.1.20, AKR1A1, ALDR1, ALR
Inter-individual variability, differential tissue abundance, and sub-cellular localization of human aldo-keto reductases (AKRs) and hydroxy-steroid dehydrogenases (HSDs)., PMID:40484033
The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming., PMID:40161620
RORα inhibits proliferation and chemoresistance through AKR1A1-induced glucose and lipid reprogramming in gastric cancer., PMID:40096932
Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis., PMID:39972314
Deciphering the cell type-specific and zonal distribution of drug-metabolizing enzymes, transporters, and transcription factors in livers of mice using single-cell transcriptomics., PMID:39919554
C-C motif chemokine ligand 2 regulates prostaglandin synthesis and embryo attachment of the bovine endometrium during implantation., PMID:38438567
Multiomics Analyses Identify AKR1A1 as a Biomarker for Diabetic Kidney Disease., PMID:38394643
Exploring KRAS-mutant pancreatic ductal adenocarcinoma: a model validation study., PMID:38268915
In vitro evaluation of the reductive carbonyl idarubicin metabolism to evaluate inhibitors of the formation of cardiotoxic idarubicinol via carbonyl and aldo-keto reductases., PMID:38175295
Endogenous reductase activities for the generation of ribitol-phosphate, a CDP-ribitol precursor, in mammals., PMID:38140954
Mechanistic study of the Aldo-keto reductase family 1 member A1 in regulating mesenchymal stem cell fate decision toward adipogenesis and osteogenesis., PMID:38092142
Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response., PMID:38062420
Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine., PMID:37722844
Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition., PMID:36623880
A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis., PMID:36288700
Kefir peptides ameliorate osteoporosis in AKR1A1 knockout mice with vitamin C deficiency by promoting osteoblastogenesis and inhibiting osteoclastogenesis., PMID:36252352
Global landscape of protein complexes in postprandial-state livers from diet-induced obese and lean mice., PMID:36099783
Dietary Inclusion of Dried Chicory Root Affects Cecal Mucosa Proteome of Nursery Pigs., PMID:35804609
The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency., PMID:35679914
Characterization, expression, and function analysis of AKR1A1 gene from yellow catfish (Tachysurus fulvidraco)., PMID:35113310
AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity., PMID:34938315
Synthesis of indole-substituted thiosemicarbazones as an aldose reductase inhibitor: an in vitro, selectivity and in silico study., PMID:34148377
Association between the genetic polymorphisms of the pharmacokinetics of anthracycline drug and myelosuppression in a patient with breast cancer with anthracycline-based chemotherapy., PMID:33774021
Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels., PMID:33549889
(5-Hydroxy-4-oxo-2-styryl-4H-pyridin-1-yl)-acetic Acid Derivatives as Multifunctional Aldose Reductase Inhibitors., PMID:33158254
Proteomic Analysis of Atrial Appendages Revealed the Pathophysiological Changes of Atrial Fibrillation., PMID:33041871
Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers., PMID:33036882
Ascorbic acid prevents N-nitrosodiethylamine-induced hepatic injury and hepatocarcinogenesis in Akr1a-knockout mice., PMID:32805337
Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens?, PMID:32588086
High-throughput, Label-Free Quantitative Proteomic Studies of the Anticancer Effects of Electrical Pulses with Turmeric Silver Nanoparticles: an in vitro Model Study., PMID:32350346
Dimeric dihydrodiol dehydrogenase is an efficient primate 1,5-anhydro-D-fructose reductase., PMID:32253031
Validation and identification of reference genes in Chinese hamster ovary cells for Fc-fusion protein production., PMID:32216463
AKR1A1 is a novel mammalian S-nitroso-glutathione reductase., PMID:31649033
Novel 2-phenoxypyrido[3,2-b]pyrazin-3(4H)-one derivatives as potent and selective aldose reductase inhibitors with antioxidant activity., PMID:31347930
Affinity Isolation and Mass Spectrometry Identification of Prostacyclin Synthase (PTGIS) Subinteractome., PMID:31226805
Identification of a novel glycolysis-related gene signature that can predict the survival of patients with lung adenocarcinoma., PMID:30727821
Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3., PMID:30703376
Benzoxazinone-thiosemicarbazones as antidiabetic leads via aldose reductase inhibition: Synthesis, biological screening and molecular docking study., PMID:30551808
Molecular recognition of S-nitrosothiol substrate by its cognate protein denitrosylase., PMID:30538128
Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury., PMID:30487609
Selective Inhibition of Human AKR1B10 by n-Humulone, Adhumulone and Cohumulone Isolated from Humulus lupulus Extract., PMID:30469331
Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury., PMID:29763686
l-Glutamine Attenuates Apoptosis in Porcine Enterocytes by Regulating Glutathione-Related Redox Homeostasis., PMID:29659951
Proteomics reveals changes in hepatic proteins during chicken embryonic development: an alternative model to study human obesity., PMID:29310583
Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin., PMID:29117945
The impact of sesquiterpenes β-caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo., PMID:29098926
Identification of new potent inhibitor of aldose reductase from Ocimum basilicum., PMID:28917123
Reductive metabolism of tiaprofenic acid by the human liver and recombinant carbonyl reducing enzymes., PMID:28322780
A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice., PMID:28060768
Characterization of Tilapia (Oreochromis niloticus) aldehyde reductase (AKR1A1) gene, promoter and expression pattern in benzo-a-pyrene exposed fish., PMID:27800707
For research use only. Not for human or drug use.
