Catalog No.
EHA95601
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Asn374
Predicted molecular weight
42.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60609
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GDNF family receptor alpha-3, GDNF receptor alpha-3, GDNFR-alpha-3, GFR-alpha-3, GFRA3, UNQ339/PRO538/PRO3664
The neurotrophic factor artemin and its receptor GFRα3 mediate migraine-like pain via the ion channel TRPM8., PMID:39552306
Discovery of the first selective, small-molecule GFRα2/3 inhibitors through DNA-encoded library technology., PMID:39004318
ARTN-GFRA3 axis induces epithelial-mesenchymal transition phenotypes, migration, and invasion of gastric cancer cells via KRAS signaling., PMID:38958711
Sex differences in colonic gene expression and fecal microbiota composition in a mouse model of obesity-associated colorectal cancer., PMID:38347027
Members of the CUGBP Elav-like family of RNA-binding proteins are expressed in distinct populations of primary sensory neurons., PMID:37537886
A new art to treating osteoarthritis pain?, PMID:37460008
Identification and validation of a novel cuproptosis-related signature as a prognostic model for lung adenocarcinoma., PMID:36353226
Runs of Homozygosity Revealed Reproductive Traits of Hu Sheep., PMID:36292733
Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients., PMID:33600668
GDNF Receptor Agonist Alleviates Motor Imbalance in Unilateral 6-Hydroxydopamine Model of Parkinson's Disease., PMID:33479704
Human splenic TER cells: A relevant prognostic factor acting via the artemin-GFRα3-ERK pathway in pancreatic ductal adenocarcinoma., PMID:33236361
Gonadotroph tumours with a low SF-1 labelling index are more likely to recur and are associated with enrichment of the PI3K-AKT pathway., PMID:33128255
Identification of differentially expressed genes regulated by methylation in colon cancer based on bioinformatics analysis., PMID:31341364
A population of nonneuronal GFRα3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells., PMID:31302761
RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia., PMID:29654265
Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression., PMID:29606356
Transcriptome profiling identified differentially expressed genes and pathways associated with tamoxifen resistance in human breast cancer., PMID:29423105
Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells., PMID:28937965
Artemin transiently increases iNOS expression in primary cultured trigeminal ganglion neurons., PMID:28899786
Paired Expression Analysis of Tumor Cell Surface Antigens., PMID:28871274
Downregulations of TRPM8 expression and membrane trafficking in dorsal root ganglion mediate the attenuation of cold hyperalgesia in CCI rats induced by GFRα3 knockdown., PMID:28867384
Expression of GFRα3 correlates with tumor progression and promotes cell metastasis in urothelial carcinoma., PMID:28651425
Identification of targets of tumor suppressor microRNA-34a using a reporter library system., PMID:28356515
Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons., PMID:28270618
Expression of artemin and GFRα3 in an animal model of migraine: possible role in the pathogenesis of this disorder., PMID:27600145
Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFRα3., PMID:27051069
GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer., PMID:26984265
Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes., PMID:26904955
Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas., PMID:26576643
Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome., PMID:26270588
Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush., PMID:25918373
Enhanced nonpeptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch., PMID:25640289
Artemin growth factor increases nicotinic cholinergic receptor subunit expression and activity in nociceptive sensory neurons., PMID:24886596
Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain., PMID:23884957
Artemin-GFRα3 interactions partially contribute to acute inflammatory hypersensitivity., PMID:23603259
Prognostic significance of the expression of GFRα1, GFRα3 and syndecan-3, proteins binding ARTEMIN, in mammary carcinoma., PMID:23351331
Neurotrophic artemin promotes motility and invasiveness of MIA PaCa-2 pancreatic cancer cells., PMID:22901124
Label-free epitope binning assays of monoclonal antibodies enable the identification of antigen heterogeneity., PMID:22609372
Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET/GFRA3 receptors., PMID:22031517
Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression., PMID:21590285
Ret signalling integrates a craniofacial muscle module during development., PMID:21490065
Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents., PMID:21193524
Enhanced artemin/GFRα3 levels regulate mechanically insensitive, heat-sensitive C-fiber recruitment after axotomy and regeneration., PMID:21123573
Insulin-like 3 exposure of the fetal rat gubernaculum modulates expression of genes involved in neural pathways., PMID:20631401
Artemin-stimulated progression of human non-small cell lung carcinoma is mediated by BCL2., PMID:20530713
Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response., PMID:20116071
Taste disturbance after stapes surgery--clinical and experimental study., PMID:19848245
Behavioral and cellular level changes in the aging somatosensory system., PMID:19686222
Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice., PMID:19580811
Functional RET G691S polymorphism in cutaneous malignant melanoma., PMID:19561646
For research use only. Not for human or drug use.
