Catalog No.
EHK17201
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Arg60-Val191
Predicted molecular weight
44.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UHP7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
C-type lectin domain family 2 member D, Lectin-like NK cell receptor, Lectin-like transcript 1, LLT-1, Osteoclast inhibitory lectin, CLEC2D, CLAX, LLT1, OCIL
Whole-Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib., PMID:40388487
Combined CLEC2d Expression and CD58 Loss Mitigate Rejection of Allogeneic T Cells., PMID:40171839
Associations of genetic polymorphisms with clinical response to tocilizumab in Chinese rheumatoid arthritis patients., PMID:39718059
Single-cell RNA-sequencing of human spleens reveals an IDO-1+ tolerogenic dendritic cell subset in pancreatic cancer patients that is absent in normal individuals., PMID:39547331
Targeting LLT1 as a potential immunotherapy option for cancer patients non-responsive to existing checkpoint therapies in multiple solid tumors., PMID:39511540
Potential molecular mechanisms of ETV6-RUNX1-positive B progenitor cell cluster in acute lymphoblastic leukemia revealed by single-cell RNA sequencing., PMID:39498293
Identification of the novel exhausted T cell CD8 + markers in breast cancer., PMID:39160211
Comprehensive pan-cancer analysis of KLRB1-CLEC2D pair and identification of small molecule inhibitors to disrupt their interaction., PMID:39133960
GENETIC ABLATION OF THE C-TYPE LECTIN RECEPTOR CLEC2D INCREASES PERITONITIS MORTALITY, INFLAMMATION, AND PHYSIOLOGY WITHOUT DIMINISHING ORGAN INJURY., PMID:38888567
Transcriptional switches in melanoma T Cells: Facilitating polarizing into regulatory T cells., PMID:38885605
Single-cell analysis reveals cellular and molecular factors counteracting HPV-positive oropharyngeal cancer immunotherapy outcomes., PMID:38857913
Lectin-like Transcript-1 (LLT1) Expression in Oral Squamous Cell Carcinomas: Prognostic Significance and Relationship with the Tumor Immune Microenvironment., PMID:38673902
C-type lectin 2D (CLEC2D) is upregulated in clear cell renal cell carcinoma (ccRCC) tissues and predicts poor prognosis., PMID:38509909
Immune checkpoint CD161/LLT1-associated immunological landscape and diagnostic value in oral squamous cell carcinoma., PMID:38502058
Targeting of the CD161 inhibitory receptor enhances T-cell-mediated immunity against hematological malignancies., PMID:38153903
C-TYPE LECTIN-2D RECEPTOR CONTRIBUTES TO HISTONE-INDUCED VASCULAR BARRIER DYSFUNCTION DURING BURN INJURY., PMID:37878490
C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity., PMID:37872182
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer's disease., PMID:37291336
SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis., PMID:37287972
Differential Expression of LLT1, SLAM Receptors CS1 and 2B4 and NCR Receptors NKp46 and NKp30 in Pediatric Acute Lymphoblastic Leukemia (ALL)., PMID:36835271
Designing Cancer Immunotherapies That Engage T Cells and NK Cells., PMID:36446137
Extracellular Nucleosomes Accelerate Microglial Inflammation via C-Type Lectin Receptor 2D and Toll-Like Receptor 9 in mPFC of Mice With Chronic Stress., PMID:35844599
LLT1-CD161 Interaction in Cancer: Promises and Challenges., PMID:35185935
Therapeutic Potential of Human Nasal Inferior Turbinate-Derived Stem Cells: Microarray Analysis of Multilineage Differentiation., PMID:34488222
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis., PMID:33592174
A novel prognostic prediction model based on seven immune-related RNAs for predicting overall survival of patients in early cervical squamous cell carcinoma., PMID:33588862
Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells., PMID:33288556
Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells., PMID:33202767
Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals., PMID:32449811
Epigenetic Alterations Are Associated With Gastric Emptying Disturbances in Diabetes Mellitus., PMID:32352713
An EBNA3A-Mutated Epstein-Barr Virus Retains the Capacity for Lymphomagenesis in a Cord Blood-Humanized Mouse Model., PMID:32132242
Clec2d Joins the Cell Death Sensor Ranks., PMID:31951550
Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury., PMID:31859049
Diuron exposure and Akt overexpression promote glioma formation through DNA hypomethylation., PMID:31727122
Mouse Cytomegalovirus m153 Protein Stabilizes Expression of the Inhibitory NKR-P1B Ligand Clr-b., PMID:31597762
Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma., PMID:30955082
Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition., PMID:30397201
Regulation of antitumor miR-144-5p targets oncogenes: Direct regulation of syndecan-3 and its clinical significance., PMID:29968393
The Inhibitory NKR-P1B:Clr-b Recognition Axis Facilitates Detection of Oncogenic Transformation and Cancer Immunosurveillance., PMID:29691253
Biological and Clinical Significance of Human NKRP1A/LLT1 Receptor/Ligand Interactions., PMID:31002602
A Role of NKR-P1A (CD161) and Lectin-like Transcript 1 in Natural Cytotoxicity against Human Articular Chondrocytes., PMID:29212911
High-level expression and purification of soluble form of human natural killer cell receptor NKR-P1 in HEK293S GnTI- cells., PMID:28757467
Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition., PMID:28288457
Vaccinia virus Western Reserve induces rapid surface expression of a host molecule detected by the antibody 4C7 that is distinct from CLEC2D., PMID:27862195
Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction., PMID:27626681
Multi-functional lectin-like transcript-1: A new player in human immune regulation., PMID:27477771
Genetic and clinical biomarkers of tocilizumab response in patients with rheumatoid arthritis., PMID:27339827
LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation., PMID:26829983
Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis., PMID:26147876
Crystal structure of extracellular domain of human lectin-like transcript 1 (LLT1), the ligand for natural killer receptor-P1A., PMID:25826155
For research use only. Not for human or drug use.
