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InVivoMAb Anti-HIV2 gp125 Antibody (7C8)

Catalog #:   VVV26701 Specific References (66) DATASHEET
Host species: Human
Isotype: IgG1
Applications: ELISA, Neutralization
Accession: Q74432
Overview

Catalog No.

VVV26701

Species reactivity

Human immunodeficiency virus 2

Host species

Human

Isotype

IgG1

Clonality

Monoclonal

Target

Surface glycoprotein, gp125

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q74432

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

7C8

Note

For research use only. Not suitable for clinical or therapeutic use.

Data Image
  • SDS-PAGE
    SDS PAGE for HIV2 gp125 Antibody (7C8)
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Transmembrane envelope glycoproteins of human immunodeficiency virus type 2 and simian immunodeficiency virus SIV-mac exist as homodimers., PMID:2296088

Immunoprecipitation of human immunodeficiency virus type 2 glycoproteins by sera positive for human immunodeficiency virus type 1., PMID:2229392

Vaccine protection against HIV-2 infection in cynomolgus monkeys., PMID:2064826

Characterization of human antibody-binding sites on the external envelope of human immunodeficiency virus type 2., PMID:1710645

Hyperimmune antisera against synthetic peptides representing the glycoprotein of human immunodeficiency virus type 2 can mediate neutralization and antibody-dependent cytotoxic activity., PMID:2068087

Identification of B-cell antigenic sites on HIV-2 gp125., PMID:1370692

Specificity of antibody-dependent cellular cytotoxicity in sera from human immunodeficiency virus type 2-infected individuals., PMID:7504937

Two neutralizing domains in the V3 region in the envelope glycoprotein gp125 of HIV type 2., PMID:8120399

Long-standing protection of macaques against cell-free HIV-2 with a HIV-2 iscom vaccine., PMID:8176640

Characterization of monoclonal antibodies to human immunodeficiency virus type 2 envelope glycoproteins., PMID:7888225

Evaluation of HIV-1/HIV-2 immunoblots for detection of HIV-2 antibodies., PMID:15566829

Immunogenicity and protective efficacy of a human immunodeficiency virus type 2 recombinant canarypox (ALVAC) vaccine candidate in cynomolgus monkeys., PMID:8896498

Linear and cyclic peptides mimicking the disulfide loops in HIV-2 envelope glycoprotein induced antibodies with different specificity., PMID:9566765

Antigenicity of linear and cyclic peptides mimicking the disulfide loops in HIV-2 envelope glycoprotein: synthesis, reoxidation and purification., PMID:9606017

Characterization of neutralizing sites in the second variable and fourth variable region in gp125 and a conserved region in gp36 of human immunodeficiency virus type 2., PMID:10333245

Human neutralizing human immunodeficiency virus type 2-specific Fab molecules generated by phage display., PMID:10466795

Fine characterization of a V3-region neutralizing epitope in human immunodeficiency virus type 2., PMID:10854165

Serum immunoglobulin A (IgA)-mediated immunity in human immunodeficiency virus type 2 (HIV-2) infection., PMID:12706073

Potent neutralizing serum immunoglobulin A (IgA) in human immunodeficiency virus type 2-exposed IgG-seronegative individuals., PMID:15194778

Cloning, expression, and purification of HIV-2 gp125: A target for HIV vaccination., PMID:15920286

Use of a new dual-antigen enzyme-linked immunosorbent assay to detect and characterize the human antibody response to the human immunodeficiency virus type 2 envelope gp125 and gp36 glycoproteins., PMID:16455923

Deletion of the V1/V2 region does not increase the accessibility of the V3 region of recombinant gp125., PMID:16611061

HIV-2 neutralization by intact V3-specific Fab fragments., PMID:18706111

Envelope-specific antibody response in HIV-2 infection: C2V3C3-specific IgG response is associated with disease progression., PMID:18981765

Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8., PMID:19574645

Potent and broadly reactive HIV-2 neutralizing antibodies elicited by a vaccinia virus vector prime-C2V3C3 polypeptide boost immunization strategy., PMID:20844029

A highly sensitive and specific time resolved fluorometric bridge assay for antibodies to HIV-1 and -2., PMID:21232554

Crystal structure of the HIV-2 neutralizing Fab fragment 7C8 with high specificity to the V3 region of gp125., PMID:21541316

Long-standing protection of macaques against cell-free HIV-2 with a HIV-2 iscom vaccine. PMID: 8176640

Virological and molecular demonstration of human immunodeficiency virus type 2 vertical transmission. PMID: 9525673

Vaccine protection against HIV-2 infection in cynomolgus monkeys. PMID: 2064826

Specificity of antibody-dependent cellular cytotoxicity in sera from human immunodeficiency virus type 2-infected individuals. PMID: 7504937

Hyperimmune antisera against synthetic peptides representing the glycoprotein of human immunodeficiency virus type 2 can mediate neutralization and antibody-dependent cytotoxic activity. PMID: 2068087

In vivo genetic variability of the human immunodeficiency virus type 2 V3 region. PMID: 1602560

Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8. PMID: 19574645

Human neutralizing human immunodeficiency virus type 2-specific Fab molecules generated by phage display. PMID: 10466795

Cell-mediated immunity to low doses of SIVsm in cynomolgus macaques did not confer protection against mucosal rechallenge. PMID: 10930685

Cross-protection against mucosal simian immunodeficiency virus (SIVsm) challenge in human immunodeficiency virus type 2-vaccinated cynomolgus monkeys. PMID: 11413371

The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells. PMID: 8995623

Potent and broadly reactive HIV-2 neutralizing antibodies elicited by a vaccinia virus vector prime-C2V3C3 polypeptide boost immunization strategy. PMID: 20844029

Characterization of human antibody-binding sites on the external envelope of human immunodeficiency virus type 2. PMID: 1710645

Serum immunoglobulin A (IgA)-mediated immunity in human immunodeficiency virus type 2 (HIV-2) infection. PMID: 12706073

Fine characterization of a V3-region neutralizing epitope in human immunodeficiency virus type 2. PMID: 10854165

Linear and cyclic peptides mimicking the disulfide loops in HIV-2 envelope glycoprotein induced antibodies with different specificity. PMID: 9566765

Envelope-specific antibody response in HIV-2 infection: C2V3C3-specific IgG response is associated with disease progression. PMID: 18981765

A highly sensitive and specific time resolved fluorometric bridge assay for antibodies to HIV-1 and -2. PMID: 21232554

HIV-2 neutralization by intact V3-specific Fab fragments. PMID: 18706111

Immunoprecipitation of human immunodeficiency virus type 2 glycoproteins by sera positive for human immunodeficiency virus type 1. PMID: 2229392

HIV-2 A-subtype gp125c₂-v₃-c₃ mutations and their association with CCR5 and CXCR4 tropism. PMID: 21814863

Transmembrane envelope glycoproteins of human immunodeficiency virus type 2 and simian immunodeficiency virus SIV-mac exist as homodimers. PMID: 2296088

Potent neutralizing serum immunoglobulin A (IgA) in human immunodeficiency virus type 2-exposed IgG-seronegative individuals. PMID: 15194778

Characterization of human immunodeficiency virus type 2 envelope glycoproteins: dimerization of the glycoprotein precursor during processing. PMID: 2911118

Evaluation of HIV-1/HIV-2 immunoblots for detection of HIV-2 antibodies. PMID: 15566829

Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125. PMID: 9079375

HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients. PMID: 20463072

Antigenicity of linear and cyclic peptides mimicking the disulfide loops in HIV-2 envelope glycoprotein: synthesis, reoxidation and purification. PMID: 9606017

Two neutralizing domains in the V3 region in the envelope glycoprotein gp125 of HIV type 2. PMID: 8120399

Characterization of neutralizing sites in the second variable and fourth variable region in gp125 and a conserved region in gp36 of human immunodeficiency virus type 2. PMID: 10333245

Immunogenicity and protective efficacy of a human immunodeficiency virus type 2 recombinant canarypox (ALVAC) vaccine candidate in cynomolgus monkeys. PMID: 8896498

Use of a new dual-antigen enzyme-linked immunosorbent assay to detect and characterize the human antibody response to the human immunodeficiency virus type 2 envelope gp125 and gp36 glycoproteins. PMID: 16455923

Characterization of monoclonal antibodies to human immunodeficiency virus type 2 envelope glycoproteins. PMID: 7888225

Identification of B-cell antigenic sites on HIV-2 gp125. PMID: 1370692

Cloning, expression, and purification of HIV-2 gp125: A target for HIV vaccination. PMID: 15920286

Computational Modulation of the V3 Region of Glycoprotein gp125 of HIV-2. PMID: 33669351

Crystal structure of the HIV-2 neutralizing Fab fragment 7C8 with high specificity to the V3 region of gp125. PMID: 21541316

Deletion of the V1/V2 region does not increase the accessibility of the V3 region of recombinant gp125. PMID: 16611061

Datasheet
$ 350
Product specifications
100 μg 350 1 mg 1400 5 mg 4200

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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InVivoMAb Anti-HIV2 gp125 Antibody (7C8) [VVV26701]
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