Catalog No.
YHK83101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile1030-Lys1265
Predicted molecular weight
28.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96Q42
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Alsin, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, ALS2CR6, Amyotrophic lateral sclerosis 2 protein, ALS2, KIAA1563
Association of ALS genes in strains of the genus Candida with cervical cytological alterations., PMID:40383620
Identification of Alzheimer's disease biomarkers and their immune function characterization., PMID:40190307
Effects of Pro197 resistance mutations occurring in different acetolactate synthase (ALS) isozymes on Descurainia sophia L. resistance to tribenuron-methyl., PMID:40015855
Genetic epidemiology of amyotrophic lateral sclerosis in Cyprus: a population-based study., PMID:39730482
Trp-574-Leu and the novel Pro-197-His/Leu mutations contribute to penoxsulam resistance in Echinochloa crus-galli (L.) P. Beauv., PMID:39654963
Pro-197-Ser mutation combinations in acetolactate synthase (ALS) homoeologous genes affect ALS inhibitor herbicide resistance levels in Monochoria korsakowii., PMID:39643926
Phenotype and Genotype of Children with ALS2 gene-Related Disorder., PMID:39424348
Mutations in target gene confers resistance to acetolactate synthase inhibitors in Echinochloa phyllopogon., PMID:39406000
Unveiling therapeutic biomarkers and druggable targets in ALS: An integrative microarray analysis, molecular docking, and structural dynamic studies., PMID:39299050
New targets and designed inhibitors of ASAP Arf-GAPs derived from structural characterization of the ASAP1/440-kD ankyrin-B interaction., PMID:39265663
Connecting genes to whole plants in dilution effect of target-site ALS inhibitor resistance of Schoenoplectiella juncoides (Roxb.) Lye (Cyperaceae)., PMID:39084788
Conformational Dynamics and Molecular Characterization of Alsin MORN Monomer and Dimeric Assemblies., PMID:39023312
Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β-catenin signaling., PMID:38847490
Amyotrophic Lateral Sclerosis due to ALS2 Pathogenic Variant Masquerading as Cerebral Palsy: Correspondence., PMID:38514515
Rapid Antibacterial Activity Assessment of Chimeric Lysins., PMID:38397110
Amyotrophic Lateral Sclerosis due to ALS2 Pathogenic Variant Masquerading as Cerebral Palsy., PMID:38393638
A Retrospective Review of 18 Patients With Childhood-Onset Hereditary Spastic Paraplegia, Nine With Novel Variants., PMID:38301322
Clinical features and molecular genetic investigation of infantile-onset ascending hereditary spastic paralysis (IAHSP) in two Chinese siblings caused by a novel splice site ALS2 variation., PMID:38297306
Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration., PMID:38239833
Trp-574-Leu mutation and metabolic resistance by cytochrome P450 gene conferred high resistance to ALS-inhibiting herbicides in Descurainia sophia., PMID:38225062
Target gene mutations endowed cross-resistance to acetolactate synthase-inhibiting herbicides in wild Brassica juncea., PMID:38072540
Heterozygous SPTLC1 p.Leu39del is a major cause of slow-progressing juvenile ALS., PMID:38041669
Target-Site and Metabolic Resistance Mechanisms to Penoxsulam in Late Watergrass (Echinochloa phyllopogon) in China., PMID:37934576
Proteomic profiling of the brain from the wobbler mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein., PMID:37565261
Genetic Investigation of Consanguineous Pakistani Families Segregating Rare Spinocerebellar Disorders., PMID:37510308
Rapid Screening and Comparison of Chimeric Lysins for Antibacterial Activity against Staphylococcus aureus Strains., PMID:37107029
Clinical and molecular spectrum of a large Egyptian cohort with ALS2-related disorders of infantile-onset of clinical continuum IAHSP/JPLS., PMID:37055917
Genetic landscape of ALS in Malta based on a quinquennial analysis., PMID:36549973
Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes., PMID:36459881
Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies., PMID:36296656
mRNA Capture Sequencing and RT-qPCR for the Detection of Pathognomonic, Novel, and Secondary Fusion Transcripts in FFPE Tissue: A Sarcoma Showcase., PMID:36232302
Genotype-phenotype correlation in Tunisian patients with Amyotrophic Lateral Sclerosis., PMID:36108486
A novel mutation in the ALS2 gene in an iranian kurdish family with juvenile amyotrophic lateral sclerosis., PMID:35852402
Development and validation of monoclonal antibodies specific for Candida albicans Als2, Als9-1, and Als9-2., PMID:35802580
Multiple roles for the cytoskeleton in ALS., PMID:35714755
FUS positive juvenile ALS-diagnostic and therapeutic insights from a 16-year-old female patient., PMID:35290622
Phenotype and genotype spectrum of variants in guanine nucleotide exchange factor genes in a broad cohort of Iranian patients., PMID:35174982
ALS2-Related Motor Neuron Diseases: From Symptoms to Molecules., PMID:35053075
Infantile onset ascending hereditary spastic paralysis., PMID:35039335
ALS2-related disorders in Spanish children: a severely affected case of infantile ascending spastic paraplegia due to homozygous R704X mutation., PMID:35032227
Target-Site Mutations and Expression of ALS Gene Copies Vary According to Echinochloa Species., PMID:34828447
The expanding clinical and genetic spectrum of alsin-related disorders: the first cohort of Brazilian patients., PMID:34738851
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS., PMID:34321318
The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2., PMID:34243065
Questioning the causality of HTT CAG-repeat expansions in FTD/ALS., PMID:34139183
Author Response: Phenotypic Variability in ALS-FTD and Effect on Survival., PMID:34099533
Reader Response: Phenotypic Variability in ALS-FTD and Effect on Survival., PMID:34099532
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS., PMID:34021139
Dysregulation of IGF-1/GLP-1 signaling in the progression of ALS: potential target activators and influences on neurological dysfunctions., PMID:34018075