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Recombinant Human ALS2/Alsin Protein, N-His

Catalog #:   YHK83101 Specific References (49) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: Q96Q42
Protein length: Ile1030-Lys1265
Overview

Catalog No.

YHK83101

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Ile1030-Lys1265

Predicted molecular weight

28.94 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q96Q42

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Alsin, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, ALS2CR6, Amyotrophic lateral sclerosis 2 protein, ALS2, KIAA1563

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human ALS2/Alsin protein
References

Association of ALS genes in strains of the genus Candida with cervical cytological alterations., PMID:40383620

Identification of Alzheimer's disease biomarkers and their immune function characterization., PMID:40190307

Effects of Pro197 resistance mutations occurring in different acetolactate synthase (ALS) isozymes on Descurainia sophia L. resistance to tribenuron-methyl., PMID:40015855

Genetic epidemiology of amyotrophic lateral sclerosis in Cyprus: a population-based study., PMID:39730482

Trp-574-Leu and the novel Pro-197-His/Leu mutations contribute to penoxsulam resistance in Echinochloa crus-galli (L.) P. Beauv., PMID:39654963

Pro-197-Ser mutation combinations in acetolactate synthase (ALS) homoeologous genes affect ALS inhibitor herbicide resistance levels in Monochoria korsakowii., PMID:39643926

Phenotype and Genotype of Children with ALS2 gene-Related Disorder., PMID:39424348

Mutations in target gene confers resistance to acetolactate synthase inhibitors in Echinochloa phyllopogon., PMID:39406000

Unveiling therapeutic biomarkers and druggable targets in ALS: An integrative microarray analysis, molecular docking, and structural dynamic studies., PMID:39299050

New targets and designed inhibitors of ASAP Arf-GAPs derived from structural characterization of the ASAP1/440-kD ankyrin-B interaction., PMID:39265663

Connecting genes to whole plants in dilution effect of target-site ALS inhibitor resistance of Schoenoplectiella juncoides (Roxb.) Lye (Cyperaceae)., PMID:39084788

Conformational Dynamics and Molecular Characterization of Alsin MORN Monomer and Dimeric Assemblies., PMID:39023312

Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β-catenin signaling., PMID:38847490

Amyotrophic Lateral Sclerosis due to ALS2 Pathogenic Variant Masquerading as Cerebral Palsy: Correspondence., PMID:38514515

Rapid Antibacterial Activity Assessment of Chimeric Lysins., PMID:38397110

Amyotrophic Lateral Sclerosis due to ALS2 Pathogenic Variant Masquerading as Cerebral Palsy., PMID:38393638

A Retrospective Review of 18 Patients With Childhood-Onset Hereditary Spastic Paraplegia, Nine With Novel Variants., PMID:38301322

Clinical features and molecular genetic investigation of infantile-onset ascending hereditary spastic paralysis (IAHSP) in two Chinese siblings caused by a novel splice site ALS2 variation., PMID:38297306

Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration., PMID:38239833

Trp-574-Leu mutation and metabolic resistance by cytochrome P450 gene conferred high resistance to ALS-inhibiting herbicides in Descurainia sophia., PMID:38225062

Target gene mutations endowed cross-resistance to acetolactate synthase-inhibiting herbicides in wild Brassica juncea., PMID:38072540

Heterozygous SPTLC1 p.Leu39del is a major cause of slow-progressing juvenile ALS., PMID:38041669

Target-Site and Metabolic Resistance Mechanisms to Penoxsulam in Late Watergrass (Echinochloa phyllopogon) in China., PMID:37934576

Proteomic profiling of the brain from the wobbler mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein., PMID:37565261

Genetic Investigation of Consanguineous Pakistani Families Segregating Rare Spinocerebellar Disorders., PMID:37510308

Rapid Screening and Comparison of Chimeric Lysins for Antibacterial Activity against Staphylococcus aureus Strains., PMID:37107029

Clinical and molecular spectrum of a large Egyptian cohort with ALS2-related disorders of infantile-onset of clinical continuum IAHSP/JPLS., PMID:37055917

Genetic landscape of ALS in Malta based on a quinquennial analysis., PMID:36549973

Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes., PMID:36459881

Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies., PMID:36296656

mRNA Capture Sequencing and RT-qPCR for the Detection of Pathognomonic, Novel, and Secondary Fusion Transcripts in FFPE Tissue: A Sarcoma Showcase., PMID:36232302

Genotype-phenotype correlation in Tunisian patients with Amyotrophic Lateral Sclerosis., PMID:36108486

A novel mutation in the ALS2 gene in an iranian kurdish family with juvenile amyotrophic lateral sclerosis., PMID:35852402

Development and validation of monoclonal antibodies specific for Candida albicans Als2, Als9-1, and Als9-2., PMID:35802580

Multiple roles for the cytoskeleton in ALS., PMID:35714755

FUS positive juvenile ALS-diagnostic and therapeutic insights from a 16-year-old female patient., PMID:35290622

Phenotype and genotype spectrum of variants in guanine nucleotide exchange factor genes in a broad cohort of Iranian patients., PMID:35174982

ALS2-Related Motor Neuron Diseases: From Symptoms to Molecules., PMID:35053075

Infantile onset ascending hereditary spastic paralysis., PMID:35039335

ALS2-related disorders in Spanish children: a severely affected case of infantile ascending spastic paraplegia due to homozygous R704X mutation., PMID:35032227

Target-Site Mutations and Expression of ALS Gene Copies Vary According to Echinochloa Species., PMID:34828447

The expanding clinical and genetic spectrum of alsin-related disorders: the first cohort of Brazilian patients., PMID:34738851

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS., PMID:34321318

The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2., PMID:34243065

Questioning the causality of HTT CAG-repeat expansions in FTD/ALS., PMID:34139183

Author Response: Phenotypic Variability in ALS-FTD and Effect on Survival., PMID:34099533

Reader Response: Phenotypic Variability in ALS-FTD and Effect on Survival., PMID:34099532

Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS., PMID:34021139

Dysregulation of IGF-1/GLP-1 signaling in the progression of ALS: potential target activators and influences on neurological dysfunctions., PMID:34018075

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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For research use only. Not for human or drug use.

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Recombinant Human ALS2/Alsin Protein, N-His [YHK83101]
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