Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody. PMID: 33468698
Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice. PMID: 36224625
Key Molecular Events in Cervical Cancer Development. PMID: 31319555
MicroRNA-130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2. PMID: 30906471
HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m6A-MYC expression. PMID: 35002506
p16/ki67 and E6/E7 mRNA Accuracy and Prognostic Value in Triaging HPV DNA-Positive Women. PMID: 32745170
Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model. PMID: 28599791
E6/E7 and E6* From HPV16 and HPV18 Upregulate IL-6 Expression Independently of p53 in Keratinocytes. PMID: 31396215
HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein. PMID: 30945125
Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. PMID: 26386540
IL-6/STAT3 mediates the HPV18 E6/E7 stimulated upregulation of MALAT1 gene in cervical cancer HeLa cells. PMID: 32113834
Gene Targeting of HPV18 E6 and E7 Synchronously by Nonviral Transfection of CRISPR/Cas9 System in Cervical Cancer. PMID: 31989837
Development and validation of a multiplex immunoassay for the simultaneous quantification of type-specific IgG antibodies to E6/E7 oncoproteins of HPV16 and HPV18. PMID: 32214362
Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1. PMID: 33436409
Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells. PMID: 35036522
Treatment with Radix Euphorbiae Ebracteolatae Significantly Decreases the Expression of E6 and L1, and Increases the Expression of p53 and Rb in HPV18-infected Human Foreskin Keratinocytes. PMID: 30813877
Down-regulation of HPV18 E6, E7, or VEGF expression attenuates malignant biological behavior of human cervical cancer cells. PMID: 21222176
Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells. PMID: 32399935
The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells. PMID: 20639900
Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial. PMID: 33271094
The Major Constituent of Green Tea, Epigallocatechin-3-Gallate (EGCG), Inhibits the Growth of HPV18-Infected Keratinocytes by Stimulating Proteasomal Turnover of the E6 and E7 Oncoproteins. PMID: 33920477
Human Papillomavirus (HPV) 16/18 E6 Oncoprotein Expression in Infections with Single and Multiple Genotypes. PMID: 30606718
HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1. PMID: 30230542
NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription. PMID: 27323853
Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation. PMID: 25157104
STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. PMID: 29630659
SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells. PMID: 25300249
Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer. PMID: 30242022
Phylogeny and Classification of Human Papillomavirus (HPV)16 and HPV18 Variants Based on E6 and L1 genes in Tunisian Women with Cervical Lesions. PMID: 30583341
Blocking activity of the HPV18 virus in cervical cancer cells using the CRISPR/Cas9 system. PMID: 31949818
HPV18 oncoproteins driven expression of PKM2 reprograms HeLa cell metabolism to maintain aerobic glycolysis and viability. PMID: 36277414
Development and validation of a multiplex qPCR assay for detection and relative quantification of HPV16 and HPV18 E6 and E7 oncogenes. PMID: 33597592
E6 Oncoproteins from High-Risk Human Papillomavirus Induce Mitochondrial Metabolism in a Head and Neck Squamous Cell Carcinoma Model. PMID: 31398842
Functional interaction of p53 with HPV18 E6, c-myc and H-ras in 3T3 cells. PMID: 1321402
CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells. PMID: 34280810
[Expression of VEGF, KDR, p53, E6 HPV16 and HPV18 in vulvar and cervix cancer]. PMID: 10983377
Construction and identification of a yeast two-hybrid bait vector and its effect on the growth of yeast cells and the self-activating function of reporter genes for screening of HPV18 E6-interacting protein. PMID: 20155448
Gene expression profiles induced by E6 from non-European HPV18 variants reveals a differential activation on cellular processes driving to carcinogenesis. PMID: 22743128
A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer. PMID: 32151670
Determination of Human Papillomavirus Type 18 Lineage of E6: A Population Study from Iran. PMID: 35342765
Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization. PMID: 29346075
Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression. PMID: 19122673
Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus. PMID: 25797137
Genetic Variability in the E6, E7, and L1 Genes of Human Papillomavirus Types 16 and 18 among Women in Saudi Arabia. PMID: 36680149
Human papillomavirus type 18 E6*, E6, and E7 protein synthesis in cell-free translation systems and comparison of E6 and E7 in vitro translation products to proteins immunoprecipitated from human epithelial cells. PMID: 1651423
Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai. PMID: 31832087
HPV18 DNA replication inactivates the early promoter P55 activity and prevents viral E6 expression. PMID: 27822719
Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy. PMID: 27465494
Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques. PMID: 18455277
Human papillomavirus type 18 E6 and E7 genes integrate into human hepatoma derived cell line Hep G2. PMID: 22655088
HPV16 E6 Promotes the Progression of HPV Infection-Associated Cervical Cancer by Upregulating Glucose-6-Phosphate Dehydrogenase Expression. PMID: 34692493
Regulation of Na(+)-coupled glucose carrier SGLT1 by human papillomavirus 18 E6 protein. PMID: 21156162
E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway. PMID: 19007961
Characterization of human papillomavirus (HPV) 16 E6 seropositive individuals without HPV-associated malignancies after 10 years of follow-up in the UK Biobank. PMID: 33248371
BAG3 down-modulation sensitizes HPV18(+) HeLa cells to PEITC-induced apoptosis and restores p53. PMID: 25175321
The Curcumin Analogue 1,5-Bis(2-hydroxyphenyl)-1,4-pentadiene-3-one Induces Apoptosis and Downregulates E6 and E7 Oncogene Expression in HPV16 and HPV18-Infected Cervical Cancer Cells. PMID: 26132907
Molecular dissection of the E6 PBM identifies essential residues regulating Chk1 phosphorylation and subsequent 14-3-3 recognition. PMID: 36775199
Regulation of p14ARF expression by HPV-18 E6 variants. PMID: 23918540
For research use only. Not for human or drug use.
