Catalog No.
YVV15301
Expression system
E. coli
Species
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Protein length
His468-Pro607
Predicted molecular weight
17.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P03211
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Epstein-Barr nuclear antigen 1, EBNA-1, EBV nuclear antigen 1, EBNA1, BKRF1
Epstein-Barr virus and multiple sclerosis. PMID: 35931816
EBNA1. PMID: 26428370
Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases. PMID: 34691042
Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats. PMID: 37046091
EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers. PMID: 30555548
Role of EBNA1 in NPC tumourigenesis. PMID: 22206863
Epstein-Barr virus-encoded EBNA1 and ZEBRA: targets for therapeutic strategies against EBV-carrying cancers. PMID: 25186125
Cryo-EM Structure and Functional Studies of EBNA1 Binding to the Family of Repeats and Dyad Symmetry Elements of Epstein-Barr Virus oriP. PMID: 36037477
EBNA1 and host factors in Epstein-Barr virus latent DNA replication. PMID: 23031715
Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency. PMID: 28077791
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis. PMID: 37196088
Targeted disruption of EBNA1 in EBV-infected cells attenuated cell growth. PMID: 26879316
The Epstein-Barr virus EBNA1 protein modulates the alternative splicing of cellular genes. PMID: 30832682
Potential cellular functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus. PMID: 23325328
Contributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survival. PMID: 23170171
EBV-encoded EBNA1 regulates cell viability by modulating miR34a-NOX2-ROS signaling in gastric cancer cells. PMID: 29061308
EBNA2 and Its Coactivator EBNA-LP. PMID: 26428371
Targeting Epstein-Barr virus to treat MS. PMID: 35590190
Analysis of the mechanism regulating the killing effect of EBNA1 on EBV-associated B-cell tumors. PMID: 36800829
Computational analysis of EBNA1 "druggability" suggests novel insights for Epstein-Barr virus inhibitor design. PMID: 27048620
Control of Viral Latency by Episome Maintenance Proteins. PMID: 31624007
Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer. PMID: 25031339
EBNA1 regulates cellular gene expression by binding cellular promoters. PMID: 20080792
Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance. PMID: 21209116
4C Analysis of EBV-Host DNA Interactome. PMID: 36534285
Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system. PMID: 36350639
FR-like EBNA1 binding repeats in the human genome. PMID: 20655080
EBNA1 and LMP1 variants in multiple sclerosis cases and controls. PMID: 20636447
Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance. PMID: 28701406
The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4. PMID: 18922874
Epstein-Barr Virus and Multiple Sclerosis: New Light on an Old Idea BjornevikKCorteseMHealyBCKuhleJMinaMJLengY, and others. 2022. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science375(6578):296-301. LanzTVBrewerRCHoPPMoonJSJudeKMFernandezD, and others. Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature2022;603:321-7. PMID: 35441540
Functions of the Epstein-Barr virus EBNA1 protein in viral reactivation and lytic infection. PMID: 22491455
Large-scale Epstein-Barr virus EBNA1 protein purification. PMID: 18848996
Phosphorylation sites of Epstein-Barr virus EBNA1 regulate its function. PMID: 19439552
Dominant-negative derivative of EBNA1 represses EBNA1-mediated transforming gene expression during the acute phase of Epstein-Barr virus infection independent of rapid loss of viral genome. PMID: 20132216
The affinity of EBNA1 for its origin of DNA synthesis is a determinant of the origin's replicative efficiency. PMID: 18385243
EBNA1 efficiently assembles on chromatin containing the Epstein-Barr virus latent origin of replication. PMID: 14585343
DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization. PMID: 21910783
[Mechanisms of EBV-mediated oncogenesis]. PMID: 17446669
EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PMID: 19834552
The sequence analysis of Epstein-Barr virus EBNA1 gene: could viral screening markers for nasopharyngeal carcinoma be identified? PMID: 30203133
Nucleoside diphosphate kinase/Nm23 and Epstein-Barr virus. PMID: 19412732
EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells. PMID: 24821080
Functional analyses of the EBNA1 origin DNA binding protein of Epstein-Barr virus. PMID: 10799567
For research use only. Not for human or drug use.
