Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody. PMID: 33468698
Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice. PMID: 36224625
Key Molecular Events in Cervical Cancer Development. PMID: 31319555
MicroRNA-130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2. PMID: 30906471
HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m6A-MYC expression. PMID: 35002506
p16/ki67 and E6/E7 mRNA Accuracy and Prognostic Value in Triaging HPV DNA-Positive Women. PMID: 32745170
Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model. PMID: 28599791
E6/E7 and E6* From HPV16 and HPV18 Upregulate IL-6 Expression Independently of p53 in Keratinocytes. PMID: 31396215
HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein. PMID: 30945125
Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. PMID: 26386540
IL-6/STAT3 mediates the HPV18 E6/E7 stimulated upregulation of MALAT1 gene in cervical cancer HeLa cells. PMID: 32113834
Gene Targeting of HPV18 E6 and E7 Synchronously by Nonviral Transfection of CRISPR/Cas9 System in Cervical Cancer. PMID: 31989837
Development and validation of a multiplex immunoassay for the simultaneous quantification of type-specific IgG antibodies to E6/E7 oncoproteins of HPV16 and HPV18. PMID: 32214362
Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1. PMID: 33436409
Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells. PMID: 35036522
Treatment with Radix Euphorbiae Ebracteolatae Significantly Decreases the Expression of E6 and L1, and Increases the Expression of p53 and Rb in HPV18-infected Human Foreskin Keratinocytes. PMID: 30813877
Down-regulation of HPV18 E6, E7, or VEGF expression attenuates malignant biological behavior of human cervical cancer cells. PMID: 21222176
Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells. PMID: 32399935
The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells. PMID: 20639900
Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial. PMID: 33271094
The Major Constituent of Green Tea, Epigallocatechin-3-Gallate (EGCG), Inhibits the Growth of HPV18-Infected Keratinocytes by Stimulating Proteasomal Turnover of the E6 and E7 Oncoproteins. PMID: 33920477
Human Papillomavirus (HPV) 16/18 E6 Oncoprotein Expression in Infections with Single and Multiple Genotypes. PMID: 30606718
HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1. PMID: 30230542
NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription. PMID: 27323853
Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation. PMID: 25157104
STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. PMID: 29630659
SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells. PMID: 25300249
Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer. PMID: 30242022
Phylogeny and Classification of Human Papillomavirus (HPV)16 and HPV18 Variants Based on E6 and L1 genes in Tunisian Women with Cervical Lesions. PMID: 30583341
Blocking activity of the HPV18 virus in cervical cancer cells using the CRISPR/Cas9 system. PMID: 31949818
HPV18 oncoproteins driven expression of PKM2 reprograms HeLa cell metabolism to maintain aerobic glycolysis and viability. PMID: 36277414
Development and validation of a multiplex qPCR assay for detection and relative quantification of HPV16 and HPV18 E6 and E7 oncogenes. PMID: 33597592
E6 Oncoproteins from High-Risk Human Papillomavirus Induce Mitochondrial Metabolism in a Head and Neck Squamous Cell Carcinoma Model. PMID: 31398842
Functional interaction of p53 with HPV18 E6, c-myc and H-ras in 3T3 cells. PMID: 1321402
CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells. PMID: 34280810
[Expression of VEGF, KDR, p53, E6 HPV16 and HPV18 in vulvar and cervix cancer]. PMID: 10983377
Construction and identification of a yeast two-hybrid bait vector and its effect on the growth of yeast cells and the self-activating function of reporter genes for screening of HPV18 E6-interacting protein. PMID: 20155448
Gene expression profiles induced by E6 from non-European HPV18 variants reveals a differential activation on cellular processes driving to carcinogenesis. PMID: 22743128
A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer. PMID: 32151670
Determination of Human Papillomavirus Type 18 Lineage of E6: A Population Study from Iran. PMID: 35342765
Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization. PMID: 29346075
Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression. PMID: 19122673
Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus. PMID: 25797137
Genetic Variability in the E6, E7, and L1 Genes of Human Papillomavirus Types 16 and 18 among Women in Saudi Arabia. PMID: 36680149
Development of an innovative approach for early diagnosis of cervical cancer using TCR‑like antibodies targeting HPV18 E6 and E7 peptides., PMID:40476553
Crosstalk Between the Oncoproteins of High-Risk Human Papillomaviruses Types 16 and 18 in Colorectal Cancer Cell Models., PMID:40468102
Innovative nomogram for cervical cancer prediction: integrating high-risk HPV infection, p53 genotype, and blood routine parameters., PMID:40463873
Investigation of HPV DNA, in-silico validation and role of E6 protein in colorectal carcinogenesis., PMID:40435002
Molecular Insights into HPV-Driven Cervical Cancer: Oncoproteins, Immune Evasion, and Epigenetic Modifications., PMID:40431173
Boosting immune response against cervical cancer: A combined approach using oncolytic virus and targeted therapies., PMID:40403026
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity., PMID:40330484
Human papilloma virus (HPV) mediated cancers: an insightful update., PMID:40301924
Human papillomavirus E2 proteins suppress innate antiviral signaling pathways., PMID:40264759
Evaluation of Onco E6 point of care rapid diagnostic test for human papilloma virus in Bahir Dar, Amhara Regional State, Ethiopia., PMID:40238760
Astragalin inhibits the proliferation of high-risk HPV-positive cervical epithelial cells and attenuates malignant cervical lesions., PMID:40124127
Recent update on the development of HPV16 inhibitors for cervical cancer., PMID:40107437
Drosophila model of HPV18-Induced pathogenesis reveals a role for E6 oncogene in regulation of NF-κB and Wnt to inhibit apoptosis., PMID:40074036
Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer., PMID:39815804
Molecular analysis of HPV16 and HPV18 oncogenes in oral squamous cell carcinoma: Structural, transcriptomic and in vitro insights., PMID:39807101
DARPin-induced reactivation of p53 in HPV-positive cells., PMID:39789211
Designing of an mRNA vaccine against high-risk human papillomavirus targeting the E6 and E7 oncoproteins exploiting immunoinformatics and dynamic simulation., PMID:39761277
Comparative efficacy of HPV 16/18 DNA and E6/E7 mRNA testing in detecting high-grade cervical lesions (CIN2+) in women with cervical biopsies., PMID:39733635
Improved efficacy of therapeutic HPV DNA vaccine using intramuscular injection with electroporation compared to conventional needle and needle-free jet injector methods., PMID:39722048
Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4., PMID:39688415
Genome-Wide Analysis of p53 Targets Reveals SCN2A as a Novel Player in p53-Induced Cell Arrest in HPV-Positive Cells., PMID:39599840
[A fluorescence immunochromatography method for detection of human papillomavirus type 16 E6 and L1 proteins]., PMID:39584350
The Distribution of HR-HPV E6/E7 DNA and mRNA by Histological Grade and the Clinical Performance for Detection of Cervical Cancer and Precancer., PMID:39540331
The anti-tumor efficacy of a recombinant oncolytic herpes simplex virus mediated CRISPR/Cas9 delivery targeting in HPV16-positive cervical cancer., PMID:39536909
Detection of transcriptionally active high-risk human papillomavirus in patients with oesophageal carcinoma by real-time PCR., PMID:39412909
Recombinant adenoviruses expressing HPV16/18 E7 upregulate the HDAC6 and DNMT3B genes in C33A cells., PMID:39411320
Human Papillomaviruses 16 and 18 E6 Oncoprotein Detection Test in Primary Oropharyngeal Carcinomas and Metastatic Lymph Nodes: A Cross-Sectional Study., PMID:39404976
PRMT1 Modulates Alternative Splicing to Enhance HPV18 mRNA Stability and Promote the Establishment of Infection., PMID:39386465
Signaling pathways in HPV-induced cervical cancer: Exploring the therapeutic promise of RNA modulation., PMID:39357186
Microfluid biosensor for detection of hpv in patient scraping samples: Determining E6 and E7 oncogenes., PMID:39146929
HPV18 E6/E7 activates Ca2+ influx to promote the malignant progression of cervical cancer by inhibiting Ca2+ binding protein 1 expression., PMID:39113388
Immunoinformatics approach for design novel multi-epitope prophylactic and therapeutic vaccine based on capsid proteins L1 and L2 and oncoproteins E6 and E7 of human papillomavirus 16 and human papillomavirus 18 against cervical cancer., PMID:39039819
Comparison of preclinical efficacy of immunotherapies against HPV-induced cancers., PMID:38978164
Genetic variability of human papillomavirus type 18 based on E6, E7 and L1 genes in central China., PMID:38970084
Tirbanibulin decreases cell proliferation and downregulates protein expression of oncogenic pathways in human papillomavirus containing HeLa cells., PMID:38967656
Advances in human papillomavirus detection and molecular understanding in head and neck cancers: Implications for clinical management., PMID:38884391
HPV-18 E6 enhances the interaction between EMILIN2 and SNX27 to promote WNT signaling., PMID:38874360
Small molecule NMD and MDM2 inhibitors synergistically trigger apoptosis in HeLa cells., PMID:38871298
Development of an mRNA-based therapeutic vaccine mHTV-03E2 for high-risk HPV-related malignancies., PMID:38715363
In vitro study of HPV18-positive cervical cancer HeLa cells based on CRISPR/Cas13a system., PMID:38710293
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer., PMID:38624210
Interferon-γ-induced GBP1 is an inhibitor of human papillomavirus 18., PMID:38622605
Biplex quantitative PCR to detect transcriptionally active human papillomavirus 16 from patient saliva., PMID:38600473
Antibodies against high-risk human papillomavirus proteins as markers for noncervical HPV-related cancers in a Black South African population, according to HIV status., PMID:38577820
Distribution of human papillomavirus among Vietnamese women with cervical cancer and unusual genetic variability of HPV16., PMID:38520797
Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies., PMID:38514186
Three-dimensional chromatin analysis reveals Sp1 as a mediator to program and reprogram HPV-host epigenetic architecture in cervical cancer., PMID:38471646
Bioinformatics analysis of photoexcited natural flavonoid glycosides as the inhibitors for oropharyngeal HPV oncoproteins., PMID:38466452
Evaluation of HPV 16 and HPV 18 Oncoprotein Expression as Alternative Diagnostic Tools in Cervical Lesion., PMID:38415538
ErbB2/HER2 receptor tyrosine kinase regulates human papillomavirus promoter activity., PMID:38370412
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