Catalog No.
YVV09001
Expression system
E. coli
Species
Human papillomavirus type 16
Protein length
Met1-Leu158
Predicted molecular weight
21.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P03126
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein E6, E6
HPV16 E6 promotes cell proliferation, migration, and invasion of human cervical cancer cells by elevating both EMT and stemness characteristics. PMID: 34957655
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. PMID: 26789255
Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice. PMID: 35089069
HnRNP D activates production of HPV16 E1 and E6 mRNAs by promoting intron retention. PMID: 35234917
Deep Sequencing of HPV16 E6 Region Reveals Unique Mutation Pattern of HPV16 and Predicts Cervical Cancer. PMID: 35735983
HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1. PMID: 30230542
The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells. PMID: 36847693
Degradation of p53 by HPV16-E6 variants isolated from cervical cancer specimens of Moroccan women. PMID: 33984442
HPV16 E6 and E7 Oncoproteins Stimulate the Glutamine Pathway Maintaining Cell Proliferation in a SNAT1-Dependent Fashion. PMID: 36851539
High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression. PMID: 35475668
Adjunctive testing by cytology, p16/Ki-67 dual-stained cytology or HPV16/18 E6 oncoprotein for the management of HPV16/18 screen-positive women. PMID: 33252834
HPV16 E6 Controls the Gap Junction Protein Cx43 in Cervical Tumour Cells. PMID: 26445057
Identification of HPV16's E6 gene in suspected cases of cervical lesions and docking Study of its L1 protein with active components of Echinacea purpurae. PMID: 36032471
Interferon-γ and IL-5 associated cell-mediated immune responses to HPV16 E2 and E6 distinguish between persistent oral HPV16 infections and noninfected mucosa. PMID: 33421352
HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells. PMID: 28720067
HPV16 E6 polymorphism and physical state of viral genome in relation to the risk of cervical cancer in women from the south of Poland. PMID: 27801430
USP15 inhibits HPV16 E6 degradation and catalytically inactive USP15 has reduced inhibitory activity. PMID: 29895155
A Critical Role for p53 during the HPV16 Life Cycle. PMID: 35608342
Sensitivity and specificity of antibodies against HPV16 E6 and other early proteins for the detection of HPV16-driven oropharyngeal squamous cell carcinoma. PMID: 28316084
HPV16 oncogenes E6 or/and E7 may influence the methylation status of RASSFIA gene promoter region in cervical cancer cell line HT-3. PMID: 28260046
Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women. PMID: 23946477
HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. PMID: 25439690
Human Papillomavirus (HPV) 16 E6 seropositivity is elevated in subjects with oral HPV16 infection. PMID: 27344614
A novel function of HPV16-E6/E7 in epithelial-mesenchymal transition. PMID: 23628416
Diagnostic Utility of HPV16 E6 mRNA or E7 mRNA Quantitative Expression for Cervical Cells of Patients with Dysplasia and Carcinoma. PMID: 30056761
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China. PMID: 34217247
Brd4 inhibition suppresses HPV16 E6 expression and enhances chemoresponse: A potential new target in cervical cancer therapy. PMID: 30421459
HPV16 E6 oncoprotein increases cell adhesion in human keratinocytes. PMID: 19066713
Human papillomavirus type 16 E6 induces cell competition. PMID: 35320322
HPV16 E6 variants: frequency, association with HPV types and in silico analysis of the identified novel variants. PMID: 24610458
Distinctive distribution of HPV16 E6 D25E and E7 N29S intratypic Asian variants in Korean commercial sex workers. PMID: 17311337
Specific Magnetic Isolation of E6 HPV16 Modified Magnetizable Particles Coupled with PCR and Electrochemical Detection. PMID: 27164078
Correlation of HPV16 L1 capsid protein expression in cervical dysplasia with HPV16 DNA concentration, HPV16 E6*I mRNA and histologic outcome. PMID: 19697723
Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay. PMID: 35225653
HPV16-transformed human keratinocytes depend on SIX1 expression for proliferation and HPV E6/E7 gene expression. PMID: 31425971
[Expression of Daxx and HPV16 E6 and its significance in cervical lesions]. PMID: 26814089
Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription. PMID: 31915229
Relationship of HPV16 E6 seropositivity with circulating tumor tissue modified HPV16 DNA before head and neck cancer diagnosis. PMID: 37148655
HPV prevalence, E6 sequence variation and physical state of HPV16 isolates from patients with cervical cancer in Sichuan, China. PMID: 16970982
HPV16-E6 Oncoprotein Activates TGF-β and Wnt/β-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model. PMID: 29888254
Differential localization of HPV16 E6 splice products with E6-associated protein. PMID: 15960845
The small splice variant of HPV16 E6, E6, reduces tumor formation in cervical carcinoma xenografts. PMID: 24503078
Genetic variability of the HPV16 early genes and LCR. Present and future perspectives. PMID: 34847982
Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors. PMID: 33485370
[Effects of hnRNP E1 on expression of early genes E2, E6 of HPV16 and biological function in cervical cancer cells]. PMID: 33626623
Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation. PMID: 33115863
HPV16 E6 natural variants exhibit different activities in functional assays relevant to the carcinogenic potential of E6. PMID: 16519914
Systematic Analysis of IL-1 Cytokine Signaling Suppression by HPV16 Oncoproteins. PMID: 36342298
A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer. PMID: 32151670
Genetic variation in the E6 and E7 genes of human papillomavirus type 16 in northeastern Argentina. PMID: 34569642
A Drosophila model of HPV16-induced cancer reveals conserved disease mechanism. PMID: 36508448
Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women. PMID: 31670402
A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responses. PMID: 19645010
Cellular Functions of HPV16 E5 Oncoprotein during Oncogenic Transformation. PMID: 33106372
Identification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells. PMID: 27457222
Human Papillomavirus E6/E7 and Long Noncoding RNA TMPOP2 Mutually Upregulated Gene Expression in Cervical Cancer Cells. PMID: 30728257
Identification of novel E6-E7 sequence variants of human papillomavirus 16. PMID: 23208280
Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance. PMID: 21489588
Transforming Properties of Beta-3 Human Papillomavirus E6 and E7 Proteins. PMID: 32669468
Fused toes homolog, a potential molecular regulator of human papillomavirus type 16 E6 and E7 oncoproteins in cervical cancer. PMID: 35421154
Genetic Variability in the E6, E7, and L1 Genes of Human Papillomavirus Types 16 and 18 among Women in Saudi Arabia. PMID: 36680149
Genetic and epigenetic changes of HPV16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression. PMID: 21911249
New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer. PMID: 18157144
Comparative analysis of HPV16 gene expression profiles in cervical and in oropharyngeal squamous cell carcinoma. PMID: 28423662
Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes. PMID: 23523766
SOX2 as a New Regulator of HPV16 Transcription. PMID: 28678184
Small molecule inhibitors of the HPV16-E6 interaction with caspase 8. PMID: 22300659
Effects of HPV Pseudotype Virus in Cutting E6 Gene Selectively in SiHa Cells. PMID: 30074178
Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization. PMID: 29346075
A transcriptomic landscape of human papillomavirus 16 E6-regulated gene expression and splicing events. PMID: 27859058
For research use only. Not for human or drug use.
