HPV16 E6 promotes cell proliferation, migration, and invasion of human cervical cancer cells by elevating both EMT and stemness characteristics. PMID: 34957655
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. PMID: 26789255
Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice. PMID: 35089069
HnRNP D activates production of HPV16 E1 and E6 mRNAs by promoting intron retention. PMID: 35234917
Deep Sequencing of HPV16 E6 Region Reveals Unique Mutation Pattern of HPV16 and Predicts Cervical Cancer. PMID: 35735983
HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1. PMID: 30230542
The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells. PMID: 36847693
Degradation of p53 by HPV16-E6 variants isolated from cervical cancer specimens of Moroccan women. PMID: 33984442
HPV16 E6 and E7 Oncoproteins Stimulate the Glutamine Pathway Maintaining Cell Proliferation in a SNAT1-Dependent Fashion. PMID: 36851539
High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression. PMID: 35475668
Adjunctive testing by cytology, p16/Ki-67 dual-stained cytology or HPV16/18 E6 oncoprotein for the management of HPV16/18 screen-positive women. PMID: 33252834
HPV16 E6 Controls the Gap Junction Protein Cx43 in Cervical Tumour Cells. PMID: 26445057
Identification of HPV16's E6 gene in suspected cases of cervical lesions and docking Study of its L1 protein with active components of Echinacea purpurae. PMID: 36032471
Interferon-γ and IL-5 associated cell-mediated immune responses to HPV16 E2 and E6 distinguish between persistent oral HPV16 infections and noninfected mucosa. PMID: 33421352
HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells. PMID: 28720067
HPV16 E6 polymorphism and physical state of viral genome in relation to the risk of cervical cancer in women from the south of Poland. PMID: 27801430
USP15 inhibits HPV16 E6 degradation and catalytically inactive USP15 has reduced inhibitory activity. PMID: 29895155
A Critical Role for p53 during the HPV16 Life Cycle. PMID: 35608342
Sensitivity and specificity of antibodies against HPV16 E6 and other early proteins for the detection of HPV16-driven oropharyngeal squamous cell carcinoma. PMID: 28316084
HPV16 oncogenes E6 or/and E7 may influence the methylation status of RASSFIA gene promoter region in cervical cancer cell line HT-3. PMID: 28260046
Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women. PMID: 23946477
HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. PMID: 25439690
Human Papillomavirus (HPV) 16 E6 seropositivity is elevated in subjects with oral HPV16 infection. PMID: 27344614
A novel function of HPV16-E6/E7 in epithelial-mesenchymal transition. PMID: 23628416
Diagnostic Utility of HPV16 E6 mRNA or E7 mRNA Quantitative Expression for Cervical Cells of Patients with Dysplasia and Carcinoma. PMID: 30056761
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China. PMID: 34217247
Brd4 inhibition suppresses HPV16 E6 expression and enhances chemoresponse: A potential new target in cervical cancer therapy. PMID: 30421459
HPV16 E6 oncoprotein increases cell adhesion in human keratinocytes. PMID: 19066713
Human papillomavirus type 16 E6 induces cell competition. PMID: 35320322
HPV16 E6 variants: frequency, association with HPV types and in silico analysis of the identified novel variants. PMID: 24610458
Distinctive distribution of HPV16 E6 D25E and E7 N29S intratypic Asian variants in Korean commercial sex workers. PMID: 17311337
Specific Magnetic Isolation of E6 HPV16 Modified Magnetizable Particles Coupled with PCR and Electrochemical Detection. PMID: 27164078
Correlation of HPV16 L1 capsid protein expression in cervical dysplasia with HPV16 DNA concentration, HPV16 E6*I mRNA and histologic outcome. PMID: 19697723
Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay. PMID: 35225653
HPV16-transformed human keratinocytes depend on SIX1 expression for proliferation and HPV E6/E7 gene expression. PMID: 31425971
[Expression of Daxx and HPV16 E6 and its significance in cervical lesions]. PMID: 26814089
Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription. PMID: 31915229
Relationship of HPV16 E6 seropositivity with circulating tumor tissue modified HPV16 DNA before head and neck cancer diagnosis. PMID: 37148655
HPV prevalence, E6 sequence variation and physical state of HPV16 isolates from patients with cervical cancer in Sichuan, China. PMID: 16970982
HPV16-E6 Oncoprotein Activates TGF-β and Wnt/β-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model. PMID: 29888254
Differential localization of HPV16 E6 splice products with E6-associated protein. PMID: 15960845
The small splice variant of HPV16 E6, E6, reduces tumor formation in cervical carcinoma xenografts. PMID: 24503078
Genetic variability of the HPV16 early genes and LCR. Present and future perspectives. PMID: 34847982
Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors. PMID: 33485370
[Effects of hnRNP E1 on expression of early genes E2, E6 of HPV16 and biological function in cervical cancer cells]. PMID: 33626623
Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation. PMID: 33115863
HPV16 E6 natural variants exhibit different activities in functional assays relevant to the carcinogenic potential of E6. PMID: 16519914
Systematic Analysis of IL-1 Cytokine Signaling Suppression by HPV16 Oncoproteins. PMID: 36342298
A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer. PMID: 32151670
Genetic variation in the E6 and E7 genes of human papillomavirus type 16 in northeastern Argentina. PMID: 34569642
A Drosophila model of HPV16-induced cancer reveals conserved disease mechanism. PMID: 36508448
Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women. PMID: 31670402
A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responses. PMID: 19645010
Cellular Functions of HPV16 E5 Oncoprotein during Oncogenic Transformation. PMID: 33106372
Identification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells. PMID: 27457222
Human Papillomavirus E6/E7 and Long Noncoding RNA TMPOP2 Mutually Upregulated Gene Expression in Cervical Cancer Cells. PMID: 30728257
Identification of novel E6-E7 sequence variants of human papillomavirus 16. PMID: 23208280
Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance. PMID: 21489588
Transforming Properties of Beta-3 Human Papillomavirus E6 and E7 Proteins. PMID: 32669468
Fused toes homolog, a potential molecular regulator of human papillomavirus type 16 E6 and E7 oncoproteins in cervical cancer. PMID: 35421154
Genetic Variability in the E6, E7, and L1 Genes of Human Papillomavirus Types 16 and 18 among Women in Saudi Arabia. PMID: 36680149
Genetic and epigenetic changes of HPV16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression. PMID: 21911249
New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer. PMID: 18157144
Comparative analysis of HPV16 gene expression profiles in cervical and in oropharyngeal squamous cell carcinoma. PMID: 28423662
Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes. PMID: 23523766
SOX2 as a New Regulator of HPV16 Transcription. PMID: 28678184
Small molecule inhibitors of the HPV16-E6 interaction with caspase 8. PMID: 22300659
Effects of HPV Pseudotype Virus in Cutting E6 Gene Selectively in SiHa Cells. PMID: 30074178
Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization. PMID: 29346075
A transcriptomic landscape of human papillomavirus 16 E6-regulated gene expression and splicing events. PMID: 27859058
A novel Zn2+ probe for fluorescent monitoring of drug and E6/E7 protein interaction in living cells., PMID:40480729
Crosstalk Between the Oncoproteins of High-Risk Human Papillomaviruses Types 16 and 18 in Colorectal Cancer Cell Models., PMID:40468102
Boosting immune response against cervical cancer: A combined approach using oncolytic virus and targeted therapies., PMID:40403026
Computational analysis of lupenone derivatives as potential inhibitor of human papillomavirus oncoprotein E6 associated cervical cancer., PMID:40316604
Thymoquinone enhances efficacy of cervical Cancer therapeutic vaccines via modulating CD8+ T cells., PMID:40316484
ZINC1797251, a novel natural product small molecule targets viral oncoprotein E6 in human papillomavirus-16 positive cervical cancer cells., PMID:40313056
Ad-E6/7-HR vaccine improves the prophylactic and therapeutic efficacy in HPV-associated cancers., PMID:40268519
'Nelfinavir sensitizes a clinically relevant chemo-radioresistant cervical cancer in-vitro model by targeting the AKT-USP15/USP11-HPV16 E6/E7 axis., PMID:40242402
Evaluation of Onco E6 point of care rapid diagnostic test for human papilloma virus in Bahir Dar, Amhara Regional State, Ethiopia., PMID:40238760
Recent update on the development of HPV16 inhibitors for cervical cancer., PMID:40107437
Metformin-induced E6/E7 inhibition prevents HPV-positive cancer progression through p53 reactivation., PMID:40100964
Electrochemical Duplex Detection of E2 and E6 Genes of Human Papillomavirus Type 16 and Determination of Physical Status in High-Risk Cervical Carcinoma., PMID:40071579
Rational Design of Stapled Covalent Peptide Modifiers of Oncoprotein E6 from Human Papillomavirus., PMID:40063062
[Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells]., PMID:39970121
Structural engineering of stabilized, expanded epitope nanoparticle vaccines for HPV., PMID:39958352
Dysregulation of G6PD by HPV E6 exacerbates cervical cancer by activating the STAT3/PLOD2 pathway., PMID:39943705
Discovering Active Chemotherapeutic Agents for Sexually Transmitted Diseases to Inhibit Pathogenic HPV-16-E6 Protein., PMID:39931987
E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence., PMID:39919145
Molecular epidemiology of human papillomavirus variants in cervical cancer in India., PMID:39913513
Impact of screening for human papillomavirus-positive oropharyngeal cancers: a microsimulation-based modeling study., PMID:39913364
Human Papillomavirus Type 16 E6 Seroprevalence among Men Living with HIV without HPV-Driven Malignancies., PMID:39907040
The combined immunization of cervical cancer therapeutic vaccine based on Listeria balanced lethal system has a significant therapeutic effect on tumor model mice., PMID:39870008
Vvax001, a Therapeutic Vaccine, for Patients with HPV16-Positive High-grade Cervical Intraepithelial Neoplasia: A Phase II Trial., PMID:39849926
Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation., PMID:39818213
Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer., PMID:39815804
DARPin-induced reactivation of p53 in HPV-positive cells., PMID:39789211
SLC7A11 Expression Is Up-Regulated in HPV- and Tobacco-Associated Lung Cancer., PMID:39769017
Designing of an mRNA vaccine against high-risk human papillomavirus targeting the E6 and E7 oncoproteins exploiting immunoinformatics and dynamic simulation., PMID:39761277
Characterization of the adaptive immune response in a mouse model for HPV-positive head and neck squamous cell carcinoma with implications to human disease., PMID:39751916
Comparative efficacy of HPV 16/18 DNA and E6/E7 mRNA testing in detecting high-grade cervical lesions (CIN2+) in women with cervical biopsies., PMID:39733635
[Amino Acid Substitution Patterns in the E6 and E7 Proteins of HPV Type 16: Phylogeography and Evolution]., PMID:39709561
Correlation between HPV-16 integration status and cervical intraepithelial neoplasia and cervical cancer in patients infected with HIV., PMID:39690095
Natural history of HPV-16 E6 serology among cancer-free men in a multicenter longitudinal cohort study., PMID:39658222
Amentoflavone, a biflavonoid with potential anticancer properties against viral oncoprotein E6 in Human papilloma virus-16 (HPV-16) positive cervical cancer cells., PMID:39652633
Human papillomavirus E6 alters Toll-like receptor 9 transcripts and chemotherapy responses in breast cancer cells in vitro., PMID:39644451
STING Nanoagonist Boosts Antitumor Immunity of Therapeutic DNA Vaccines., PMID:39621441
Immune Response Modulation by HPV16 Oncoproteins in Lung Cancer: Insights from Clinical and In Vitro Investigations., PMID:39599846
Genome-Wide Analysis of p53 Targets Reveals SCN2A as a Novel Player in p53-Induced Cell Arrest in HPV-Positive Cells., PMID:39599840
[A fluorescence immunochromatography method for detection of human papillomavirus type 16 E6 and L1 proteins]., PMID:39584350
ELF3 Overexpression Contributes to the Malignant Transformation of HPV16 E6/E7-Immortalized Keratinocytes by Promoting CCNE2 Expression., PMID:39572025
Detection of transcriptionally active high-risk human papillomavirus in patients with oesophageal carcinoma by real-time PCR., PMID:39412909
Recombinant adenoviruses expressing HPV16/18 E7 upregulate the HDAC6 and DNMT3B genes in C33A cells., PMID:39411320
The G-Protein-Coupled Estrogen Receptor Agonist G-1 Mediates Antitumor Effects by Activating Apoptosis Pathways and Regulating Migration and Invasion in Cervical Cancer Cells., PMID:39409923
Human Papillomaviruses 16 and 18 E6 Oncoprotein Detection Test in Primary Oropharyngeal Carcinomas and Metastatic Lymph Nodes: A Cross-Sectional Study., PMID:39404976
HPV16 E6-induced M2 macrophage polarization in the cervical microenvironment via exosomal miR-204-5p., PMID:39390116
HPV16 mutant E6/E7 construct is protective in mouse model., PMID:39350162
Comparative Analysis of HPV16 Variants in the Untranslated Regulatory Region, L1, and E6 Genes among Vaccinated and Unvaccinated Young Women: Assessing Vaccine Efficacy and Viral Diversity., PMID:39339857
cIAP-2 protein is upregulated by human papillomavirus in oropharyngeal cancers: role in radioresistance in vitro., PMID:39334439
hnRNP H controls alternative splicing of human papillomavirus type 16 E1, E6, E7, and E6^E7 mRNAs via GGG motifs., PMID:39287390
The lncRNA and miRNA regulatory axis in HPV16-positive oropharyngeal cancers., PMID:39244802
For research use only. Not for human or drug use.
