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Anti-Human TSHR/LGR3 Antibody (1H7)

Catalog #:   FHD18140 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: FCM, Neutralization, WB
Accession: P16473
Overview

Catalog No.

FHD18140

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Conjugation

Unconjugated

Target

Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3

Concentration

1.15 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16473

Applications

FCM, Neutralization, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

1H7

Data Image
  • Flow-cytometry
    Flow-cytometry using anti-human TSHR antibody.TSHR Transfected CHO cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human TSHR antibody monoclonal antibody (Catalog # FHD18140 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # PMB96441) and cells analysed on a NovoCyte Flow Cytometer.
  • Western Blot
    Various lysates were subjected to SDS PAGE followed by western blot with TSHR antibody (FHD18140) at 1 µg/ml.

    Lane 1: Mouse ovary lysate

    Second Ab: Goat Anti-Mouse IgG H&L Polyclonal antibody, HRP (PMB96431) at 0.1 μg/mL.

    Predict MW: 29, 31, 87 kDa
    Observed MW: 55 kDa
References

Monoclonal Antibodies to Thyrotropin Receptor With Thyroid-Stimulating Activity Activate the NF-κB Pathway to Induce Chemokine Expression., PMID:40500868

TSH Receptor Antibody Test Utilization Patterns from a National Reference Laboratory: TRAb, TSI, or Both?, PMID:40482060

Preclinical ImmunoPET Imaging of Thyroid-Stimulating Hormone Receptor Expression in Thyroid Cancer using [64Cu]Cu-NOTA-TSHR-Ab., PMID:40403201

Marked Increase in Thyrotropin Receptor Antibodies With the Development of Pretibial Myxedema After Total Thyroidectomy., PMID:40384886

Molecular pathway and mechanism responsible for the progress of thyroid-associated orbitopathy., PMID:40381066

Thyroid eye disease (Graves' orbitopathy): clinical presentation, epidemiology, pathogenesis, and management., PMID:40324443

Follicular helper T cells in Graves' disease: pathogenic mechanisms and therapeutic implications., PMID:40322944

Thyroid-related orbitopathy: clinical overview, novel medical treatments and the role of orbital surgery., PMID:40317422

Human Papillomavirus and Thyroid Eye Disease., PMID:40272832

Bacteroides fragilis and propionate synergize with low-dose methimazole to treat Graves' disease., PMID:40265938

Chimeric autoantibody receptor T cells specifically eliminate Graves' Disease autoreactive B cells., PMID:40264771

Antibodies against the receptor for insulin-like growth factor 1 (IGF-1RAb), insulin-like growth factor 1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP-3) in the serum of patients with Graves' and Basedow's disease with and without orbitopathy., PMID:40071798

Inflammatory and tolerogenic dendritic cells and T lymphocytes in Graves' thyroidal and orbital disease., PMID:40024060

RBM10 loss promotes metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs., PMID:39992626

Thyroid dermopathy and thyroid eye disease associated with hypofunctional autoimmune thyroid disease with high TSI/anti-TSHR antibodies improved with teprotumumab., PMID:39950657

Controversies Surrounding IGF-I Receptor Involvement in Thyroid-Associated Ophthalmopathy., PMID:39909461

Development of animal models to study aggressive thyroid cancers., PMID:39874138

Thyroid-Targeted Nano-Bombs Empower HIFU for Graves' Disease., PMID:39840533

The role of autophagy in Graves disease: knowns and unknowns., PMID:39834383

Mechanisms in Thyroid Eye Disease: The TSH Receptor Interacts Directly With the IGF-1 Receptor., PMID:39821041

Establishment of Time-Resolved Fluorescence Immunoassay for Thyrotropin Receptor Antibodies and Clinical Application., PMID:39776097

Immunization with OPN5 increased seasonal degradation of reproductive activity in Magang ganders., PMID:39754930

Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts., PMID:39747159

Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells., PMID:39723207

Mutation spectra and genotype‑phenotype analysis of congenital hypothyroidism in a neonatal population., PMID:39720292

Comparison between thyroid stimulating immunoglobulin and TSH-receptor antibodies in the diagnosis and management of Graves' disease., PMID:39669491

A novel bioassay for thyroid-blocking immunoglobulins., PMID:39534254

The TSH Receptor Antibody Reactome Contributes to Retro-Orbital Inflammation., PMID:39502473

Proangiogenic effect of thyrotropin receptor stimulating antibody in human umbilical vein endothelial cells., PMID:39455509

Hypothyroidism Induced by a TSH Receptor Peptide-Implications for Thyroid Autoimmunity., PMID:39435685

STAT3 single-nucleotide variants in autoimmune thyroid disease in the Pakhtun population of Khyber Pakhtunkhwa, Pakistan., PMID:39385969

Familial Nonautoimmune Hyperthyroidism Due to a TSH Receptor Gene Pathogenic Variant., PMID:39301178

Impact of ibrutinib on inflammation in a mouse model of Graves' orbitopathy., PMID:39280007

Zirconium- 89 Labeled Antibody K1-70 for PET Imaging of Thyroid-stimulating Hormone Receptor Expression in Thyroid Cancer., PMID:39174789

TSH Receptor Oligomers Associated With the TSH Receptor Antibody Reactome., PMID:39116382

TSHR-IGF-IR complex drives orbital fibroblast misbehavior in thyroid eye disease., PMID:39082947

Identification and functionalization of thyrotropin receptor antibodies with different antigenic epitopes., PMID:39046281

Graves disease: latest understanding of pathogenesis and treatment options., PMID:39039206

Gut microbiome in the Graves' disease: Comparison before and after anti-thyroid drug treatment., PMID:38820506

Immune checkpoints: new insights into the pathogenesis of thyroid eye disease., PMID:38817600

Minor hyperthyroidism with normal levels of thyroid-stimulating hormone receptor antibodies: a case report., PMID:38813368

A Novel Association Between Human Papillomavirus and Thyroid Eye Disease., PMID:38746201

A TSHR-Targeting Aptamer in Monocytes Correlating with Clinical Activity in TAO., PMID:38650837

A Novel TSHR Gene Mutation in a Family with Non-autoimmune Hyperthyroidism., PMID:38566871

Development and basic performance verification of a rapid homogeneous bioassay for agonistic antibodies against the thyroid-stimulating hormone receptor., PMID:38447802

The full-length TSH receptor is stabilized by TSH ligand., PMID:38373379

The evaluation of retrobulbar fat tissue in Graves' orbitopathy with shear-wave ultrasound elastography., PMID:38321200

Transition from Hashimoto thyroiditis to Graves's Disease: an unpredictable change?, PMID:38117453

Refractory Thyroid Eye Disease Unresponsive to Teprotumumab: A Case Report., PMID:38111423

Comparison of two different TSH-receptor antibody assays: A clinical practice study., PMID:38107298

Datasheet
$ 225
Product specifications
50 μg 225 100 μg 372

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Anti-Human TSHR/LGR3 Antibody (1H7) [FHD18140]
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