Catalog No.
VHB17001
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
PTP4A3, Protein-tyrosine phosphatase of regenerating liver 3, Protein-tyrosine phosphatase 4a3, PRL3, PRL-3, PRL-R, Protein tyrosine phosphatase type IVA 3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O75365
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0170
PRL3-zumab as an anti-angiogenic therapy in neovascular eye diseases., PMID:40410189
The PRL3-zumab paradigm: A multicenter, single-dose-level phase 2 basket clinical trial design of an unconventional cancer immunotherapy., PMID:40345181
Deletion of PTP4A3 phosphatase in high-grade serous ovarian cancer cells decreases tumorigenicity and produces marked changes in intracellular signaling pathways and cytokine release., PMID:39892999
Development of a high-throughput screening system targeting the protein-protein interactions between PRL and CNNM., PMID:39455715
Nasal polyp antibody-secreting cells display proliferation signature in aspirin-exacerbated respiratory disease., PMID:37898408
Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody., PMID:37674627
PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse., PMID:34326464
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein., PMID:31171773
Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer., PMID:29190795
Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion., PMID:28068414
PRL3-zumab, a first-in-class humanized antibody for cancer therapy., PMID:27699276
Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14)., PMID:27096756
[Role of molecular adjuvants TBhsp and MT in the preparation of monoclonal antibody against phosphatase of regenerating liver-3]., PMID:24909283
Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents., PMID:24625356
Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma., PMID:24330843
Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia., PMID:23929599
Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells., PMID:23867504
Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases., PMID:23729584
Suppression of breast tumor growth by DNA vaccination against phosphatase of regenerating liver 3., PMID:23364316
Phosphatase of regenerating liver-3 directly interacts with integrin β1 and regulates its phosphorylation at tyrosine 783., PMID:23092334
Downregulating PRL-3 inhibit migration and invasion of lung cancer cell via RhoA and mDia1., PMID:22825514
Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice., PMID:22374986
Targeting intracellular oncoproteins with antibody therapy or vaccination., PMID:21900592
Immunohistochemical assessment of PRL-3 (PTP4A3) expression in tumor buds, invasion front, central region of tumor and metastases of colorectal cancer., PMID:21555304
Biological function and prognostic significance of peroxisome proliferator-activated receptor δ in rectal cancer., PMID:21531809
PTP4A3 (PRL-3) expression correlate with lymphatic metastases in gastric cancer., PMID:21478108
[Expressions and significances of PRL-3 and RhoC in A549 cell]., PMID:21159255
Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma., PMID:19960436
PTP4A3 expression increases strongly in lymph node metastases from colorectal carcinoma., PMID:19846928
PRL-3 promotes epithelial mesenchymal transition by regulating cadherin directly., PMID:19440036
Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer., PMID:19322925
Prognostic significance of phosphatase of regenerating liver-3 expression in ovarian cancer., PMID:19247814
Prognostic value of PRL-3 overexpression in early stages of colonic cancer., PMID:19236507
PRL-3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up-regulating the levels and activities of Rho-A/C in lung cancer., PMID:19152186
The value and correlation between PRL-3 expression and matrix metalloproteinase activity and expression in human gliomas., PMID:18021371
Association of tyrosine PRL-3 phosphatase protein expression with peritoneal metastasis of gastric carcinoma and prognosis., PMID:17643206
[Preliminary study of PRL-3 gene promoter binding sites of Snail in SW480 cells]., PMID:17545014
Expression of the human phosphatases of regenerating liver (PRLs) in colonic adenocarcinoma and its correlation with lymph node metastasis., PMID:17440740
PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition., PMID:17409395
Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome., PMID:16873432
Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases., PMID:15788667
The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal cancer., PMID:15133662
Preparation and characterization of monoclonal antibody against protein tyrosine phosphatase PRL-3., PMID:15000845
PRL-3 expression in metastatic cancers., PMID:14654542
For research use only. Not for human or drug use.
