InVivoMAb Anti-HERV-W env/ERVW-1 Antibody (Iv0167)

Catalog No.

VHK06501

Species reactivity

Human endogenous retrovirus W, Multiple sclerosis associated retrovirus element

Host species

Human

Isotype

IgG4, kappa

Clonality

Monoclonal

Target

Recombinant envelope protein, env, Envelope protein

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q991W9

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0167

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)., PMID:40183428

HERV-W Env Induces Neuron Pyroptosis via the NLRP3-CASP1-GSDMD Pathway in Recent-Onset Schizophrenia., PMID:39859234

Immune response profiling of HERV-W envelope proteins in multiple sclerosis: potential biomarkers for disease progression., PMID:39850873

The Humoral Immune Response against Human Endogenous Retroviruses in Celiac Disease: A Case-Control Study., PMID:39200275

Antibody Response to HERV-K and HERV-W Envelope Epitopes in Patients with Myasthenia Gravis., PMID:38203616

Correlation between antibodies against the pathogenic pHERV-W envelope protein and the inflammatory phase of multiple sclerosis., PMID:37985008

Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment., PMID:37695891

Patients with psychosis spectrum disorders hospitalized during the COVID-19 pandemic unravel overlooked SARS-CoV-2 past infection clustering with HERV-W ENV expression and chronic inflammation., PMID:37524719

Association of Human Endogenous Retrovirus-W (HERV-W) Copies with Pemphigus Vulgaris., PMID:37078354

HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia., PMID:36769337

HERV-W ENV antigenemia and correlation of increased anti-SARS-CoV-2 immunoglobulin levels with post-COVID-19 symptoms., PMID:36389746

HERV-K Envelope Protein Induces Long-Lasting Production of Autoantibodies in T1DM Patients at Onset in Comparison to ZNT8 Autoantibodies., PMID:36297245

Increased Presence of Antibodies against Type I Interferons and Human Endogenous Retrovirus W in Intensive Care Unit COVID-19 Patients., PMID:35852349

Antihuman Endogenous Retrovirus Immune Response and Adaptive Dysfunction in Autism., PMID:35740387

Epstein-Barr Virus Load Correlates with Multiple Sclerosis-Associated Retrovirus Envelope Expression., PMID:35203596

HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk., PMID:35062349

HERV-K and HERV-H Env Proteins Induce a Humoral Response in Prostate Cancer Patients., PMID:35056043

Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression., PMID:34912348

Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis., PMID:34790199

Humoral Response to Microbial Biomarkers in Rheumatoid Arthritis Patients., PMID:34768672

Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study., PMID:34240656

Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics., PMID:33770381

Temelimab, an IgG4 Anti-Human Endogenous Retrovirus Monoclonal Antibody: An Early Development Safety Review., PMID:32794123

Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD., PMID:31715457

Expression of human endogenous retroviruses in pemphigus vulgaris patients., PMID:31473891

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis., PMID:31213545

Anti-HERV-WEnv antibodies are correlated with seroreactivity against Mycobacterium avium subsp. paratuberculosis in children and youths at T1D risk., PMID:31000760

Induction of Proinflammatory Multiple Sclerosis-Associated Retrovirus Envelope Protein by Human Herpesvirus-6A and CD46 Receptor Engagement., PMID:30574140

Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination., PMID:30430656

Do Human Endogenous Retroviruses Contribute to Multiple Sclerosis, and if So, How?, PMID:30047100

A new therapeutic approach for type 1 diabetes: Rationale for GNbAC1, an anti-HERV-W-Env monoclonal antibody., PMID:29749030

Humoral immunity response to human endogenous retroviruses K/W differentiates between amyotrophic lateral sclerosis and other neurological diseases., PMID:29603839

HERV Envelope Proteins: Physiological Role and Pathogenic Potential in Cancer and Autoimmunity., PMID:29593697

Antibody response against HERV-W env surface peptides differentiates multiple sclerosis and neuromyelitis optica spectrum disorder., PMID:29204291

The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes., PMID:28474333

Human endogenous retroviruses and chosen disease parameters in morphea., PMID:28261031

Multiple sclerosis-associated retrovirus, Epstein-Barr virus, and vitamin D status in patients with relapsing remitting multiple sclerosis., PMID:28165135

Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis., PMID:27456869

Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy., PMID:27211560

Expression of Syncytin 1 (HERV-W), in the preimplantation human blastocyst, embryonic stem cells and trophoblast cells derived in vitro., PMID:27173892

MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment., PMID:26857492

Natalizumab modulates the humoral response against HERV-Wenv73-88 in a follow-up study of Multiple Sclerosis patients., PMID:26190523

The neutralizing antibody GNbAC1 abrogates HERV-W envelope protein-mediated oligodendroglial maturation blockade., PMID:25480862

Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein., PMID:25427053

Hypomethylation and activation of syncytin-1 gene in endometriotic tissue., PMID:23888948

Natalizumab inhibits the expression of human endogenous retroviruses of the W family in multiple sclerosis patients: a longitudinal cohort study., PMID:23877972

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation., PMID:23836485

Env gene expression of human endogenous retrovirus-k and human endogenous retrovirus-w in childhood acute leukemia cells., PMID:23328642

Syncytin 1 in the human placenta., PMID:22381536

An N-terminally truncated envelope protein encoded by a human endogenous retrovirus W locus on chromosome Xq22.3., PMID:20735848

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