Catalog No.
RGK29702
Species reactivity
General
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Target
Polysialic acid, alpha(2,8)-linked sialic acid polysaccharide, α-2,8-linked sialic acid polymer, SIA, O-Sialic acid, α-Neu5Ac, N-acetyl-α-neuraminic acid
Concentration
0.3 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
ChEBI: 48428, ChEBI: 17012, ChEBI: 26206, ChEBI: 49026
Applications
ELISA, FCM, ITC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Ab735
Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism., PMID:40494348
Sialic Acid (Neu5Ac)-Driven Modulation of Intestinal Sialylation as a Novel Approach to Mitigating Allergic Reactions to Shrimp Tropomyosin., PMID:40396838
The sialome of the retina, alteration in age-related macular degeneration (AMD) pathology and potential impacts on Complement Factor H., PMID:40161805
Dietary intake of the red meat-derived glycan Neu5Gc fuels colorectal cancer through up-regulation of Wnt signaling pathway., PMID:40023392
Sialylation inhibition improves macrophage mediated tumor cell phagocytosis of breast cancer cells triggered by therapeutic antibodies of different isotypes., PMID:39659795
Development and evaluation of an immunoassay for the quantification of N-acetylneuraminic acid (Neu5Ac) in foods and biosamples., PMID:39178546
Neu5Gc-mediated high-affinity interaction is dispensable for CD22 cis-ligands to regulate B cell signaling., PMID:39098526
The essential malaria protein PfCyRPA targets glycans to invade erythrocytes., PMID:38573856
The Inhibitory Effect of Early Pregnancy Factor on Red Meat Neu5Gc-Mediated Antibody Production in CMAH-/- Mice., PMID:38542816
Detection of N-glycolyl-neuraminic acid-containing glycolipids in human skin., PMID:38094289
Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae., PMID:37779694
Salmonid polysialyltransferases to generate a variety of sialic acid polymers., PMID:37730806
Molecular Structural Analysis of Porcine CMAH-Native Ligand Complex and High Throughput Virtual Screening to Identify Novel Inhibitors., PMID:37242354
Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody., PMID:36711084
Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells., PMID:36419929
[Analysis and Control of Viral Infection Mechanisms by Glycobiology]., PMID:36184443
Influenza A Virus Neuraminidase Inhibitors., PMID:36175642
Antibodies Against Unusual Forms of Sialylated Glycans., PMID:35923565
An Overview of the Importance and Value of Porcine Species in Sialic Acid Research., PMID:35741423
Electrochemical Evaluation of Tumor Development via Cellular Interface Supported CRISPR/Cas Trans-Cleavage., PMID:35474904
A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and Antibody., PMID:35269703
Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated With Human-Like Neu5Gc Loss-Brief Report., PMID:34587757
Strategic feeding of NS0 and CHO cell cultures to control glycan profiles and immunogenic epitopes of monoclonal antibodies., PMID:33901620
The Lst Sialyltransferase of Neisseria gonorrhoeae Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea., PMID:33758087
A biotechnological tool for glycoprotein desialylation based on immobilized neuraminidase from Clostridium perfringens., PMID:33732900
Sequence and N-glycan diversity analysis of immunoglobulin G from buffalo milk using RP-UHPLC MS/MS., PMID:33515344
Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae., PMID:33468699
SARS-CoV 2; Possible alternative virus receptors and pathophysiological determinants., PMID:33189453
Synthesis of MUC1-derived glycopeptide bearing a novel triazole STn analog., PMID:33010570
Multi-Attribute Monitoring of Complex Erythropoetin Beta Glycosylation by GluC Liquid Chromatography-Mass Spectrometry Peptide Mapping., PMID:32426963
Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS., PMID:32014849
Specific Detection of Neu5Gc in Animal Tissues by Immunohistochemistry., PMID:32002901
Activated microglia desialylate their surface, stimulating complement receptor 3-mediated phagocytosis of neurons., PMID:31774586
N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH)., PMID:31681287
Lectin-Based Method for Deciphering Human Milk IgG Sialylation., PMID:31652515
Underlying Glycans Determine the Ability of Sialylated Lipooligosaccharide To Protect Nontypeable Haemophilus influenzae from Serum IgM and Complement., PMID:31405955
Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms., PMID:31332008
Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans-An Evolutionary Perspective., PMID:31134048
Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation., PMID:31064827
Investigation of the Potential Use of Sialic Acid as a Biomarker for Rheumatoid Arthritis., PMID:31028068
Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies., PMID:30994337
Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing α2,6-Linked 3Fax-Neu5Ac., PMID:30969765
Uptake of Sialic Acid by Nontypeable Haemophilus influenzae Increases Complement Resistance through Decreasing IgM-Dependent Complement Activation., PMID:30936154
Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2., PMID:30670592
Nontypeable Haemophilus influenzae Lipooligosaccharide Expresses a Terminal Ketodeoxyoctanoate In Vivo, Which Can Be Used as a Target for Bactericidal Antibody., PMID:30065093
Identification of KDN-Gangliosides., PMID:29926423
A Novel Sialylation Site on Neisseria gonorrhoeae Lipooligosaccharide Links Heptose II Lactose Expression with Pathogenicity., PMID:29844237
Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin., PMID:29684349
Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH., PMID:29631050
Sandwich-type biosensor for the detection of α2,3-sialylated glycans based on fullerene-palladium-platinum alloy and 4-mercaptophenylboronic acid nanoparticle hybrids coupled with Au-methylene blue-MAL signal amplification., PMID:29161664
For research use only. Not for human or drug use.
