Catalog No.
EVV15102
Expression system
Mammalian Cells
Species
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Protein length
gH [Ser19-Leu682] & gL [Asn23-Gly137]
Predicted molecular weight
74 kDa & 14 kDa (Reduced)
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P03231 & P03212
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Envelope glycoprotein H, gH, gH, BXLF2, Envelope glycoprotein L, gL, gL, BKRF2
The structural basis of herpesvirus entry. PMID: 33087881
Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases. PMID: 34691042
A bivalent Epstein-Barr virus vaccine induces neutralizing antibodies that block infection and confer immunity in humanized mice. PMID: 35507671
Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge. PMID: 35705092
gH/gL supercomplexes at early stages of herpesvirus entry. PMID: 26849495
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. PMID: 36306784
Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. PMID: 29292383
Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells. PMID: 30979688
Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry. PMID: 23107819
A Neutralizing Antibody Targeting gH Provides Potent Protection against EBV Challenge In Vivo. PMID: 35348362
Epstein-Barr Virus gH/gL and Kaposi's Sarcoma-Associated Herpesvirus gH/gL Bind to Different Sites on EphA2 To Trigger Fusion. PMID: 32847853
In silico analysis of antiviral phytochemicals efficacy against Epstein-Barr virus glycoprotein H. PMID: 33438528
Epstein-Barr virus glycoprotein gH/gL antibodies complement IgA-viral capsid antigen for diagnosis of nasopharyngeal carcinoma. PMID: 27093005
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome. PMID: 27501260
Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion. PMID: 16973550
The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment. PMID: 27935841
Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus. PMID: 27094060
Compatibility of the gH homologues of Epstein-Barr virus and related lymphocryptoviruses. PMID: 17622614
The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion. PMID: 23325693
Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function. PMID: 26656711
A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion. PMID: 23200314
Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex. PMID: 21149717
Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells. PMID: 10864642
Mapping regions of Epstein-Barr virus (EBV) glycoprotein B (gB) important for fusion function with gH/gL. PMID: 21376360
The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells. PMID: 22215569
Human MHC-II with Shared Epitope Motifs Are Optimal Epstein-Barr Virus Glycoprotein 42 Ligands-Relation to Rheumatoid Arthritis. PMID: 29361739
The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells. PMID: 25231307
Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses. PMID: 33235207
Potential entry receptors for human γ-herpesvirus into epithelial cells: A plausible therapeutic target for viral infections. PMID: 34800753
Rabbits immunized with Epstein-Barr virus gH/gL or gB recombinant proteins elicit higher serum virus neutralizing activity than gp350. PMID: 27291087
Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays. PMID: 20668073
The amino terminus of Epstein-Barr virus glycoprotein gH is important for fusion with epithelial and B cells. PMID: 16160168
The Epstein-Barr virus (EBV) BZLF2 gene product associates with the gH and gL homologs of EBV and carries an epitope critical to infection of B cells but not of epithelial cells. PMID: 7539502
Novel Epstein-Barr virus-like particles incorporating gH/gL-EBNA1 or gB-LMP2 induce high neutralizing antibody titers and EBV-specific T-cell responses in immunized mice. PMID: 27926486
Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region. PMID: 34960650
The Murid Herpesvirus-4 gL regulates an entry-associated conformation change in gH. PMID: 18665235
Maternal Epstein-Barr Virus-Specific Antibodies and Risk of Infection in Ugandan Infants. PMID: 33095855
Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies. PMID: 28939750
Epstein-Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cells. PMID: 9621012
Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). PMID: 33657166
Mutations of Epstein-Barr virus gH that are differentially able to support fusion with B cells or epithelial cells. PMID: 16103144
Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusion. PMID: 17307213
Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion. PMID: 17581996
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products. PMID: 18977445
Type I interferon and NF-κB activation elicited by herpes simplex virus gH/gL via αvβ3 integrin in epithelial and neuronal cell lines. PMID: 24109241
Functional homology of gHs and gLs from EBV-related gamma-herpesviruses for EBV-induced membrane fusion. PMID: 17477951
[The entry of Epstein-Barr virus into B lymphocytes and epithelial cells during infection]. PMID: 25272606
Four Decades of Prophylactic EBV Vaccine Research: A Systematic Review and Historical Perspective. PMID: 35493498
DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus. PMID: 3012465
A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus. PMID: 34785638
Proteins of purified Epstein-Barr virus. PMID: 15534216
Antibodies to a strain-specific citrullinated Epstein-Barr virus peptide diagnoses rheumatoid arthritis. PMID: 29487382
An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus. PMID: 29669253
Application of synthetic peptides for detection of anti-citrullinated peptide antibodies. PMID: 26796582
Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus. PMID: 17082603
Lifelong Reduction in LDL (Low-Density Lipoprotein) Cholesterol due to a Gain-of-Function Mutation in LDLR. PMID: 33315477
A novel high throughput assay to quantify Epstein-Barr virus neutralizing antibody activity against B-cell and epithelial cell infections for vaccine and therapeutic developments. PMID: 35577627
Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells. PMID: 31439152
Co-expression of the Epstein-Barr virus BXLF2 and BKRF2 genes with a recombinant baculovirus produces gp85 on the cell surface with antigenic similarity to the native protein. PMID: 8847522
Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization. PMID: 24068705
Immunoinformatic and systems biology approaches to predict and validate peptide vaccines against Epstein-Barr virus (EBV). PMID: 30679646
Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins. PMID: 27929061
Identification of the Epstein-Barr virus gp85 gene. PMID: 2831372
Insulin-like growth factor secretion by human B-lymphocytes: a comparison of cells from normal and pygmy subjects. PMID: 2551917
Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site. PMID: 28956769
Analysis of latent T-cell epitopes in Epstein-Barr virus isolated from extranodal nasal-type natural killer/T-cell lymphoma in Taiwanese population. PMID: 33242451
Association between Antibody Responses to Epstein-Barr Virus Glycoproteins, Neutralization of Infectivity, and the Risk of Nasopharyngeal Carcinoma. PMID: 33268566
Assembly and architecture of the EBV B cell entry triggering complex. PMID: 25144748
Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry. PMID: 19217393
α-Helix peptides designed from EBV-gH protein display higher antigenicity and induction of monocyte apoptosis than the native peptide. PMID: 20473772
For research use only. Not for human or drug use.
