Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion., PMID:16973550
Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusion., PMID:17307213
Functional homology of gHs and gLs from EBV-related gamma-herpesviruses for EBV-induced membrane fusion., PMID:17477951
Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion., PMID:17581996
Compatibility of the gH homologues of Epstein-Barr virus and related lymphocryptoviruses., PMID:17622614
The BDLF2 protein of Epstein-Barr virus is a type II glycosylated envelope protein whose processing is dependent on coexpression with the BMRF2 protein., PMID:18995876
Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry., PMID:19217393
Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes., PMID:19369343
Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion., PMID:19457993
Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody., PMID:21149698
Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex., PMID:21149717
Epstein-Barr virus infection of polarized epithelial cells via the basolateral surface by memory B cell-mediated transfer infection., PMID:21573183
Fusion of Epstein-Barr virus with epithelial cells can be triggered by αvβ5 in addition to αvβ6 and αvβ8, and integrin binding triggers a conformational change in glycoproteins gHgL., PMID:21957301
The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells., PMID:22215569
Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry., PMID:23107819
Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines., PMID:23279912
The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion., PMID:23325693
Assembly and architecture of the EBV B cell entry triggering complex., PMID:25144748
The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells., PMID:25231307
[The entry of Epstein-Barr virus into B lymphocytes and epithelial cells during infection]., PMID:25272606
Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers., PMID:25564465
Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism., PMID:26085146
A Viral Pilot for HCMV Navigation?, PMID:26184287
Scanning Mutagenesis of Human Cytomegalovirus Glycoprotein gH/gL., PMID:26656708
Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function., PMID:26656711
gH/gL supercomplexes at early stages of herpesvirus entry., PMID:26849495
Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus., PMID:27094060
The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment., PMID:27935841
Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies., PMID:28939750
Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site., PMID:28956769
An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus., PMID:29669253
Immunoinformatic and systems biology approaches to predict and validate peptide vaccines against Epstein-Barr virus (EBV)., PMID:30679646
Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor., PMID:30782663
Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells., PMID:30979688
Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells., PMID:31439152
Eph receptors: the bridge linking host and virus., PMID:31893311
HLA-DPB1 and Epstein-Barr virus gp42 protein jointly contribute to the development of Hodgkin lymphoma., PMID:35117807
The structural basis of herpesvirus entry., PMID:33087881
Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses., PMID:33235207
Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV)., PMID:33657166
Potential entry receptors for human γ-herpesvirus into epithelial cells: A plausible therapeutic target for viral infections., PMID:34800753
Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region., PMID:34960650
Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge., PMID:35705092
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition., PMID:36306784
Urgency and necessity of Epstein-Barr virus prophylactic vaccines., PMID:36494369
Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells., PMID:38479361
Vaccination with nanoparticles displaying gH/gL from Epstein-Barr virus elicits limited cross-protection against rhesus lymphocryptovirus., PMID:38781964
A gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge., PMID:38926438
High IgG titers against EBV glycoprotein 42 correlate with lower risk of nasopharyngeal carcinoma., PMID:39959976
Eph Receptor Tyrosine Kinases Are Functional Entry Receptors for Murine Gammaherpesvirus 68., PMID:40501621
α-Helix peptides designed from EBV-gH protein display higher antigenicity and induction of monocyte apoptosis than the native peptide. PMID: 20473772
Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry. PMID: 19217393
Assembly and architecture of the EBV B cell entry triggering complex. PMID: 25144748
Association between Antibody Responses to Epstein-Barr Virus Glycoproteins, Neutralization of Infectivity, and the Risk of Nasopharyngeal Carcinoma. PMID: 33268566
Analysis of latent T-cell epitopes in Epstein-Barr virus isolated from extranodal nasal-type natural killer/T-cell lymphoma in Taiwanese population. PMID: 33242451
Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site. PMID: 28956769
Insulin-like growth factor secretion by human B-lymphocytes: a comparison of cells from normal and pygmy subjects. PMID: 2551917
Identification of the Epstein-Barr virus gp85 gene. PMID: 2831372
Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins. PMID: 27929061
Immunoinformatic and systems biology approaches to predict and validate peptide vaccines against Epstein-Barr virus (EBV). PMID: 30679646
Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization. PMID: 24068705
Co-expression of the Epstein-Barr virus BXLF2 and BKRF2 genes with a recombinant baculovirus produces gp85 on the cell surface with antigenic similarity to the native protein. PMID: 8847522
Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells. PMID: 31439152
A novel high throughput assay to quantify Epstein-Barr virus neutralizing antibody activity against B-cell and epithelial cell infections for vaccine and therapeutic developments. PMID: 35577627
Lifelong Reduction in LDL (Low-Density Lipoprotein) Cholesterol due to a Gain-of-Function Mutation in LDLR. PMID: 33315477
Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus. PMID: 17082603
Application of synthetic peptides for detection of anti-citrullinated peptide antibodies. PMID: 26796582
An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus. PMID: 29669253
Antibodies to a strain-specific citrullinated Epstein-Barr virus peptide diagnoses rheumatoid arthritis. PMID: 29487382
Proteins of purified Epstein-Barr virus. PMID: 15534216
A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus. PMID: 34785638
DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus. PMID: 3012465
Four Decades of Prophylactic EBV Vaccine Research: A Systematic Review and Historical Perspective. PMID: 35493498
[The entry of Epstein-Barr virus into B lymphocytes and epithelial cells during infection]. PMID: 25272606
Functional homology of gHs and gLs from EBV-related gamma-herpesviruses for EBV-induced membrane fusion. PMID: 17477951
Type I interferon and NF-κB activation elicited by herpes simplex virus gH/gL via αvβ3 integrin in epithelial and neuronal cell lines. PMID: 24109241
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products. PMID: 18977445
Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion. PMID: 17581996
Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusion. PMID: 17307213
Mutations of Epstein-Barr virus gH that are differentially able to support fusion with B cells or epithelial cells. PMID: 16103144
Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). PMID: 33657166
Epstein-Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cells. PMID: 9621012
Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies. PMID: 28939750
Maternal Epstein-Barr Virus-Specific Antibodies and Risk of Infection in Ugandan Infants. PMID: 33095855
The Murid Herpesvirus-4 gL regulates an entry-associated conformation change in gH. PMID: 18665235
Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region. PMID: 34960650
Novel Epstein-Barr virus-like particles incorporating gH/gL-EBNA1 or gB-LMP2 induce high neutralizing antibody titers and EBV-specific T-cell responses in immunized mice. PMID: 27926486
The Epstein-Barr virus (EBV) BZLF2 gene product associates with the gH and gL homologs of EBV and carries an epitope critical to infection of B cells but not of epithelial cells. PMID: 7539502
The amino terminus of Epstein-Barr virus glycoprotein gH is important for fusion with epithelial and B cells. PMID: 16160168
Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays. PMID: 20668073
Rabbits immunized with Epstein-Barr virus gH/gL or gB recombinant proteins elicit higher serum virus neutralizing activity than gp350. PMID: 27291087
Potential entry receptors for human γ-herpesvirus into epithelial cells: A plausible therapeutic target for viral infections. PMID: 34800753
Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses. PMID: 33235207
The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells. PMID: 25231307
Human MHC-II with Shared Epitope Motifs Are Optimal Epstein-Barr Virus Glycoprotein 42 Ligands-Relation to Rheumatoid Arthritis. PMID: 29361739
The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells. PMID: 22215569
Mapping regions of Epstein-Barr virus (EBV) glycoprotein B (gB) important for fusion function with gH/gL. PMID: 21376360
Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells. PMID: 10864642
Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex. PMID: 21149717
A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion. PMID: 23200314
Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function. PMID: 26656711
The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion. PMID: 23325693
Compatibility of the gH homologues of Epstein-Barr virus and related lymphocryptoviruses. PMID: 17622614
Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus. PMID: 27094060
The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment. PMID: 27935841
Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion. PMID: 16973550
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome. PMID: 27501260
Epstein-Barr virus glycoprotein gH/gL antibodies complement IgA-viral capsid antigen for diagnosis of nasopharyngeal carcinoma. PMID: 27093005
In silico analysis of antiviral phytochemicals efficacy against Epstein-Barr virus glycoprotein H. PMID: 33438528
Epstein-Barr Virus gH/gL and Kaposi's Sarcoma-Associated Herpesvirus gH/gL Bind to Different Sites on EphA2 To Trigger Fusion. PMID: 32847853
A Neutralizing Antibody Targeting gH Provides Potent Protection against EBV Challenge In Vivo. PMID: 35348362
Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry. PMID: 23107819
Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells. PMID: 30979688
Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. PMID: 29292383
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. PMID: 36306784
gH/gL supercomplexes at early stages of herpesvirus entry. PMID: 26849495
Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge. PMID: 35705092
A bivalent Epstein-Barr virus vaccine induces neutralizing antibodies that block infection and confer immunity in humanized mice. PMID: 35507671
Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases. PMID: 34691042
The structural basis of herpesvirus entry. PMID: 33087881
For research use only. Not for human or drug use.
