Catalog No.
VHJ76001
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
PRSS24, STEAP1, STEAP, Metalloreductase STEAP1, Six-transmembrane epithelial antigen of prostate 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UHE8
Applications
ELISA, FCM, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0158
T-Cell Engager Therapy in Prostate Cancer: Molecular Insights into a New Frontier in Immunotherapy., PMID:40507301
The Role of STEAP1 in Prostate Cancer: Implications for Diagnosis and Therapeutic Strategies., PMID:40299363
Advances in Targeted Therapy for Metastatic Prostate Cancer., PMID:40299225
[Bispecific antibodies in prostate cancer therapy]., PMID:40172632
Targeting the tumour cell surface in advanced prostate cancer., PMID:40169837
Developmental Therapeutics in Metastatic Prostate Cancer: New Targets and New Strategies., PMID:39272956
Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen-targeted therapies., PMID:38968122
T-Cell redirecting bispecific antibodies: a review of a novel class of immuno-oncology for advanced prostate cancer., PMID:38801069
Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape., PMID:38652426
Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies., PMID:38645034
Bispecific T-cell Engagers in Metastatic Castration-Resistant Prostate Cancer., PMID:38213299
Targeting STEAP1 as an anticancer strategy., PMID:37909017
AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer., PMID:37861452
Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma., PMID:37812652
Bispecific PSMA antibodies and CAR-T in metastatic castration-resistant prostate cancer., PMID:37359737
Development of a novel electrochemical biosensor based on plastic antibodies for detection of STEAP1 biomarker in cancer., PMID:37192590
Antibody-Drug Conjugates in Prostate Cancer: A Systematic Review., PMID:36874351
STEAP1-4 (Six-Transmembrane Epithelial Antigen of the Prostate 1-4) and Their Clinical Implications for Prostate Cancer., PMID:36011027
Antibody-Drug Conjugates in Prostate Cancer: Where Are we?, PMID:35999150
Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer., PMID:35860008
Novel Redirected T-Cell Immunotherapies for Advanced Prostate Cancer., PMID:34675084
Novel potent anti-STEAP1 bispecific antibody to redirect T cells for cancer immunotherapy., PMID:34497115
Immunotherapy of prostate cancer using novel synthetic DNA vaccines targeting multiple tumor antigens., PMID:33884106
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy., PMID:33596073
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties., PMID:33596065
Treating Prostate Cancer by Antibody-Drug Conjugates., PMID:33557050
Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1)., PMID:32409586
Phase I Study of DSTP3086S, an Antibody-Drug Conjugate Targeting Six-Transmembrane Epithelial Antigen of Prostate 1, in Metastatic Castration-Resistant Prostate Cancer., PMID:31689155
Pharmacokinetics and Biodistribution of a [89Zr]Zr-DFO-MSTP2109A Anti-STEAP1 Antibody in Metastatic Castration-Resistant Prostate Cancer Patients., PMID:31117485
Imaging Patients with Metastatic Castration-Resistant Prostate Cancer Using 89Zr-DFO-MSTP2109A Anti-STEAP1 Antibody., PMID:31053681
Six-transmembrane epithelial antigen of the prostate 1 protects against increased oxidative stress via a nuclear erythroid 2-related factor pathway in colorectal cancer., PMID:30401882
Six-Transmembrane Epithelial Antigen of the Prostate-1 (STEAP-1)-Targeted Ultrasound Imaging Microbubble Improves Detection of Prostate Cancer In Vivo., PMID:30027616
Inhibition of Intercellular Communication between Prostate Cancer Cells by A Specific Anti-STEAP-1 Single Chain Antibody., PMID:29219059
Targeting STEAP1 Protein in Human Cancer: Current Trends and Future Challenges., PMID:28460619
SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance., PMID:27775699
Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics., PMID:27679517
Immunogenicity and efficacy of the novel cancer vaccine based on simian adenovirus and MVA vectors alone and in combination with PD-1 mAb in a mouse model of prostate cancer., PMID:27052571
ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1., PMID:27029064
Identification of novel vascular targets in lung cancer., PMID:25535734
Annotating STEAP1 regulation in prostate cancer with 89Zr immuno-PET., PMID:25453051
Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates., PMID:25446772
STEAP1 is overexpressed in cancers: a promising therapeutic target., PMID:23142226
The STEAP protein family: versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions., PMID:22804687
Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats., PMID:21913715
Production of antibodies against multipass membrane proteins expressed in human tumor cells using dendritic cell immunization., PMID:19390695
Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo., PMID:17575147
[Clinical significance of six-transmembrane epithelial antigen of the prostate expressed in prostatic carcinoma]., PMID:15190827
For research use only. Not for human or drug use.
