Catalog No.
DHB54006
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
TNFSF15, Vascular endothelial cell growth inhibitor, VEGI, TL1, TNF ligand-related molecule 1, Tumor necrosis factor ligand superfamily member 15, TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1
Concentration
1.81 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O95150 & P01375
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
Bispecific, AMG966, AMG-966
Clone ID
AMG 966
TL1A as a Target in Inflammatory Bowel Disease: Exploring Mechanisms and Therapeutic Potential., PMID:40507829
Using novel approaches to conjugate peptides of Macrotermes bellicosus and Curcuma longa for targeted intervention of irritable bowl diseases caused by tumor necrosis factor superfamily member 15 (TNFSF15)., PMID:40424787
Porphyromonas gingivalis outer membrane vesicles augments proliferation and metastasis of oral squamous cell carcinoma cells., PMID:40348995
Collagen (rs3134646) and ARHGAP15 (rs4662344) genetic variants may predispose to colonic diverticulosis., PMID:40274021
Unlocking the genetic code: a comprehensive Genome-Wide association study and gene set enrichment analysis of cell-mediated immunity in chickens., PMID:40181279
Combination therapy blocking TNF superfamily members 14 and 15 reverses pulmonary fibrosis., PMID:40127640
Transcriptome analysis and molecular docking reveal the activation of FOXO4, TNFSF15 and CASP9 in HeLa cells treated with DCM fraction from Clinacanthus nutans (C. nutans)., PMID:40094535
Japanese Phase 1 Study for Global Development of Anti-TL1A Antibody PF-06480605: A Randomized, Placebo-Controlled, Single-Ascending Dose Study., PMID:40065559
Linc00205/Mir-495-3p/Tnfsf15 Axis is Implicated in the Treatment Effect of Hyperbaric Oxygen Therapy on Patients with Post-Stroke Cognitive Impairment., PMID:40046208
Subtype cluster analysis unveiled the correlation between m6A- and cuproptosis-related lncRNAs and the prognosis, immune microenvironment, and treatment sensitivity of esophageal cancer., PMID:40034693
TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders., PMID:40010414
TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review., PMID:39907869
Urine proteomics defines an immune checkpoint-associated nephritis signature., PMID:39863302
Effects of dioscin from Dioscorea nipponica on TL1A/DR3 and Th9 cells in a collagen-induced arthritis mouse model., PMID:39798473
The TL1A inhibitors in IBD: what's in the pot?, PMID:39772947
Study on serum TL1A levels and their correlation with Th17 cells, IL-17 and IL-21 in children with Graves' disease., PMID:39735549
Functionalized aluminum hydroxide-based self-adjuvanted nanovaccine orchestrates antitumor immune responses via Dectin-1 signaling., PMID:39716663
Machine learning reveals CAT gene as a novel potential diagnostic and prognostic biomarker in non-small cell lung cancer., PMID:39692815
Cellular heterogeneity and cytokine signatures in acute myeloid leukemia: A novel prognostic model., PMID:39689517
TNFSF15 variant predicts disease progression in Chinese patients with Crohn's disease., PMID:39530074
Shared Pathophysiology of Inflammatory Bowel Disease and Psoriasis: Unraveling the Connection., PMID:39463646
Polybacterial Intracellular Macromolecules Shape Single-Cell Epikine Profiles in Upper Airway Mucosa., PMID:39416216
Unraveling potential gene biomarkers for dengue infection through RNA sequencing., PMID:39397194
Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis., PMID:39321363
Anti-tumor potential of high salt in breast Cancer cell lines., PMID:39305332
Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD., PMID:39266053
A Pyroptosis-Related Gene Signature Predicts Prognosis and Tumor Immune Microenvironment in Colorectal Cancer., PMID:39155627
Targeting TNFRSF25 by agonistic antibodies and multimeric TL1A proteins co-stimulated CD8+ T cells and inhibited tumor growth., PMID:39142717
Interaction of Th17 differentiations-related gene polymorphisms and environmental factors contributing to the disease classification, complications, and surgical risks of Crohn's disease in the Chinese Han population., PMID:39075019
Antibodies Targeting the Tumor Necrosis Factor-Like Ligand 1A in Inflammatory Bowel Disease: A New Kid on the (Biologics) Block?, PMID:39068930
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis., PMID:39007035
Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma., PMID:38987753
Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients., PMID:38937754
MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis., PMID:38866875
Anti-TL1A monoclonal antibody modulates the dysregulation of Th1/Th17 cells and attenuates granuloma formation in sarcoidosis by inhibiting the PI3K/AKT signaling pathway., PMID:38852524
TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway., PMID:38842774
TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice., PMID:38839915
Genetic, epigenetic and environmental factors in diverticular disease: systematic review., PMID:38831715
TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation., PMID:38597952
TL1A inhibition for inflammatory bowel disease treatment: From inflammation to fibrosis., PMID:38574740
Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening., PMID:38561797
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma., PMID:38493956
Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis., PMID:38348035
TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME., PMID:38331883
A novel prognostic classification integrating lipid metabolism and immune co-related genes in acute myeloid leukemia., PMID:38022627
TNFSF15 facilitates the differentiation of CD11b+ myeloid cells into vascular pericytes in tumors., PMID:37921408
Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974
Effects of Eimeria maxima infection doses on growth performance and gut health in dual-infection model of necrotic enteritis in broiler chickens., PMID:37799512
Identifying Luteolin as a Potential Drug for Treating Lung Adenocarcinoma with COVID-19 Affection based on Integration Analysis of Pharmacology and Transcriptome., PMID:37694790
Bradykinin-pretreated Human cardiac-specific c-kit+ Cells Enhance Exosomal miR-3059-5p and Promote Angiogenesis Against Hindlimb Ischemia in mice., PMID:37535186