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Research Grade Anti-Human TNFSF15/TL1A & TNFa/TNF-alpha Antibody (AMG 966)

Catalog #:   DHB54006 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHB54006

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

TNFSF15, Vascular endothelial cell growth inhibitor, VEGI, TL1, TNF ligand-related molecule 1, Tumor necrosis factor ligand superfamily member 15, TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1

Concentration

1.81 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O95150 & P01375

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

Bispecific, AMG966, AMG-966

Clone ID

AMG 966

Data Image
References

TL1A as a Target in Inflammatory Bowel Disease: Exploring Mechanisms and Therapeutic Potential., PMID:40507829

Using novel approaches to conjugate peptides of Macrotermes bellicosus and Curcuma longa for targeted intervention of irritable bowl diseases caused by tumor necrosis factor superfamily member 15 (TNFSF15)., PMID:40424787

Porphyromonas gingivalis outer membrane vesicles augments proliferation and metastasis of oral squamous cell carcinoma cells., PMID:40348995

Collagen (rs3134646) and ARHGAP15 (rs4662344) genetic variants may predispose to colonic diverticulosis., PMID:40274021

Unlocking the genetic code: a comprehensive Genome-Wide association study and gene set enrichment analysis of cell-mediated immunity in chickens., PMID:40181279

Combination therapy blocking TNF superfamily members 14 and 15 reverses pulmonary fibrosis., PMID:40127640

Transcriptome analysis and molecular docking reveal the activation of FOXO4, TNFSF15 and CASP9 in HeLa cells treated with DCM fraction from Clinacanthus nutans (C. nutans)., PMID:40094535

Japanese Phase 1 Study for Global Development of Anti-TL1A Antibody PF-06480605: A Randomized, Placebo-Controlled, Single-Ascending Dose Study., PMID:40065559

Linc00205/Mir-495-3p/Tnfsf15 Axis is Implicated in the Treatment Effect of Hyperbaric Oxygen Therapy on Patients with Post-Stroke Cognitive Impairment., PMID:40046208

Subtype cluster analysis unveiled the correlation between m6A- and cuproptosis-related lncRNAs and the prognosis, immune microenvironment, and treatment sensitivity of esophageal cancer., PMID:40034693

TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders., PMID:40010414

TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review., PMID:39907869

Urine proteomics defines an immune checkpoint-associated nephritis signature., PMID:39863302

Effects of dioscin from Dioscorea nipponica on TL1A/DR3 and Th9 cells in a collagen-induced arthritis mouse model., PMID:39798473

The TL1A inhibitors in IBD: what's in the pot?, PMID:39772947

Study on serum TL1A levels and their correlation with Th17 cells, IL-17 and IL-21 in children with Graves' disease., PMID:39735549

Functionalized aluminum hydroxide-based self-adjuvanted nanovaccine orchestrates antitumor immune responses via Dectin-1 signaling., PMID:39716663

Machine learning reveals CAT gene as a novel potential diagnostic and prognostic biomarker in non-small cell lung cancer., PMID:39692815

Cellular heterogeneity and cytokine signatures in acute myeloid leukemia: A novel prognostic model., PMID:39689517

TNFSF15 variant predicts disease progression in Chinese patients with Crohn's disease., PMID:39530074

Shared Pathophysiology of Inflammatory Bowel Disease and Psoriasis: Unraveling the Connection., PMID:39463646

Polybacterial Intracellular Macromolecules Shape Single-Cell Epikine Profiles in Upper Airway Mucosa., PMID:39416216

Unraveling potential gene biomarkers for dengue infection through RNA sequencing., PMID:39397194

Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis., PMID:39321363

Anti-tumor potential of high salt in breast Cancer cell lines., PMID:39305332

Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD., PMID:39266053

A Pyroptosis-Related Gene Signature Predicts Prognosis and Tumor Immune Microenvironment in Colorectal Cancer., PMID:39155627

Targeting TNFRSF25 by agonistic antibodies and multimeric TL1A proteins co-stimulated CD8+ T cells and inhibited tumor growth., PMID:39142717

Interaction of Th17 differentiations-related gene polymorphisms and environmental factors contributing to the disease classification, complications, and surgical risks of Crohn's disease in the Chinese Han population., PMID:39075019

Antibodies Targeting the Tumor Necrosis Factor-Like Ligand 1A in Inflammatory Bowel Disease: A New Kid on the (Biologics) Block?, PMID:39068930

Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis., PMID:39007035

Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma., PMID:38987753

Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients., PMID:38937754

MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis., PMID:38866875

Anti-TL1A monoclonal antibody modulates the dysregulation of Th1/Th17 cells and attenuates granuloma formation in sarcoidosis by inhibiting the PI3K/AKT signaling pathway., PMID:38852524

TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway., PMID:38842774

TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice., PMID:38839915

Genetic, epigenetic and environmental factors in diverticular disease: systematic review., PMID:38831715

TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation., PMID:38597952

TL1A inhibition for inflammatory bowel disease treatment: From inflammation to fibrosis., PMID:38574740

Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening., PMID:38561797

TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma., PMID:38493956

Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis., PMID:38348035

TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME., PMID:38331883

A novel prognostic classification integrating lipid metabolism and immune co-related genes in acute myeloid leukemia., PMID:38022627

TNFSF15 facilitates the differentiation of CD11b+ myeloid cells into vascular pericytes in tumors., PMID:37921408

Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974

Effects of Eimeria maxima infection doses on growth performance and gut health in dual-infection model of necrotic enteritis in broiler chickens., PMID:37799512

Identifying Luteolin as a Potential Drug for Treating Lung Adenocarcinoma with COVID-19 Affection based on Integration Analysis of Pharmacology and Transcriptome., PMID:37694790

Bradykinin-pretreated Human cardiac-specific c-kit+ Cells Enhance Exosomal miR-3059-5p and Promote Angiogenesis Against Hindlimb Ischemia in mice., PMID:37535186

Datasheet
$ 484
Product specifications
100 μg 484 1 mg 1932

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For research use only. Not for human or drug use.

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Research Grade Anti-Human TNFSF15/TL1A & TNFa/TNF-alpha Antibody (AMG 966) [DHB54006]
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