Inhibitors of HIV-1 Nef: applications and developments for a practical cure. PMID: 35766095
Research Progress of HIV-1 Nef Inhibitors. PMID: 33105470
Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor. PMID: 36146831
HIV-1 Nef: Taking Control of Protein Trafficking. PMID: 27161574
Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes. PMID: 32862141
HIV-1 Tat: An update on transcriptional and non-transcriptional functions. PMID: 34242726
HIV-1 Nef: at the crossroads. PMID: 18808677
HIV-1 Nef hijacks both exocytic and endocytic pathways of host intracellular trafficking through differential regulation of Rab GTPases. PMID: 35713972
Immunoregulatory effects of HIV-1 Nef protein. PMID: 19449444
Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins. PMID: 20594957
HIV-1: fifteen proteins and an RNA. PMID: 9759480
HIV-1 accessory proteins: Nef. PMID: 24158818
Structure--function relationships in HIV-1 Nef. PMID: 11463741
An HIV-1 Nef genotype that diminishes immune control mediated by protective human leucocyte antigen alleles. PMID: 32590431
Mouse Models for Studies of In Vivo Functions of HIV-1 Nef. PMID: 27438576
The HIV-1 Nef protein: how an AIDS pathogenetic factor turns to a tool for combating AIDS. PMID: 15032622
Cell-dependent functional roles of HIV-1 Nef for virus replication (review). PMID: 10085418
Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity. PMID: 31693887
Novel role of HIV-1 Nef in regulating the ubiquitination of cellular proteins. PMID: 36968110
Role of HIV-1 Nef protein for virus replication in vitro. PMID: 19770068
Role of Nef in HIV-1 replication and pathogenesis. PMID: 17586321
Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5. PMID: 31186327
Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation. PMID: 34985256
Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding. PMID: 29258818
Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes. PMID: 30927712
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence. PMID: 26950141
Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread. PMID: 32179688
Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation. PMID: 31775511
HIV-1 Nef drives macrophages into hiding. PMID: 25745180
Consequences of HLA-associated mutations in HIV-1 subtype C Nef on HLA-I downregulation ability. PMID: 31944317
HIV-1 Nef breaches placental barrier in rat model. PMID: 23240037
Zipper interacting protein kinase (ZIPK) is a negative regulator of HIV-1 replication that is restricted by viral Nef protein through proteasomal degradation. PMID: 35961135
Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction. PMID: 33800773
HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer. PMID: 23899341
Nef enhances HIV-1 infectivity via association with the virus assembly complex. PMID: 18191978
HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes. PMID: 25822027
Construction of Nef-positive doxycycline-dependent HIV-1 variants using bicistronic expression elements. PMID: 26615334
HIV-1 Nef blocks autophagy in human astrocytes. PMID: 26697833
HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication. PMID: 19781555
HIV-1 nef protein structures associated with brain infection and dementia pathogenesis. PMID: 21347424
HIV-1 nef suppression by virally encoded microRNA. PMID: 15601474
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. PMID: 26416733
HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. PMID: 12486136
HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells. PMID: 8480425
Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor. PMID: 26703715
A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. PMID: 26700863
HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis. PMID: 16445909
Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers. PMID: 36773691
The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor. PMID: 27681140
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes. PMID: 24041011
Functional characterization of HIV-1 Nef mutants in the context of viral infection. PMID: 16684552
HIV-1 Nef associates with p22-phox, a component of the NADPH oxidase protein complex. PMID: 20392440
Functions of the HIV-1 Nef protein. PMID: 15578981
Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction. PMID: 35474067
nef-deleted HIV-1 inhibits phagocytosis by monocyte-derived macrophages in vitro but not by peripheral blood monocytes in vivo. PMID: 11399976
Factors influencing HIV-1 phylogenetic clustering. PMID: 30882487
Nef-specific CD8+ T cell responses contribute to HIV-1 immune control. PMID: 24023819
Attenuation of multiple Nef functions in HIV-1 elite controllers. PMID: 23289738
The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner. PMID: 24722985
[Analysis of HIV-1 (Human immunodeficiency virus-1, Lentivirus, Orthoretrovirinae, Retroviridae) Nef protein polymorphism of variants circulating in the former USSR countries.]. PMID: 32168442
Substitution of HIV Type 1 Nef with HTLV-1 p12. PMID: 15585081
HIV-I Nef inhibitors: a novel class of HIV-specific immune adjuvants in support of a cure. PMID: 28893294
The Contribution of Extracellular Nef to HIV-Induced Pathogenesis. PMID: 26424397
HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice. PMID: 16310238
Nef of HIV-1 interacts directly with calcium-bound calmodulin. PMID: 11847276
Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. PMID: 24620746
Extracellular Nef protein regulates productive HIV-1 infection from latency. PMID: 7594542
A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef. PMID: 29386131
Antibodies to the nef protein and to nef peptides in HIV-1-infected seronegative individuals. PMID: 2786420
Gene expression profiling reveals Nef induced deregulation of lipid metabolism in HIV-1 infected T cells. PMID: 26915805
In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis. PMID: 24172637
Production and Evaluation of the Properties of HIV-1-Nef-MPER-V3 Fusion Protein Harboring IMT-P8 Cell Penetrating Peptide. PMID: 32532193
The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes. PMID: 21176845
Epitopes recognized by HIV-SF2 nef-specific CD4+ T-cell clones generated from HIV-1-uninfected donors. PMID: 7511861
Viral pathogenesis: HIV-1 Nef targets restriction factors. PMID: 26456923
Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1.93.HH8793) and H (BE.93.VI997). PMID: 30217018
Identification and Characterization of Positively Selected Mutations in Nef of Four HIV-1 Major Subtypes from Los Alamos National Laboratory. PMID: 29600767
CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. PMID: 8994833
Computer-aided de novo design and optimization of novel potential inhibitors of HIV-1 Nef protein. PMID: 37084691
HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. PMID: 8862424
HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors. PMID: 15075535
Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic. PMID: 23339631
HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. PMID: 11689886
The HIV-1 Nef protein enhances the affinity of reverse transcriptase for RNA in vitro. PMID: 12881637
The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference. PMID: 24023945
HIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursor. PMID: 18555888
Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. PMID: 17412836
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