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Anti-HIV-1 Vif/SOR protein Nanobody (SAA1421) (RVV23701)

Host species:Alpaca
Isotype:VHH-8His-Cys-tag
Applications:ELISA, IP
Expression system:Mammalian Cells
Overview

Catalog No.

RVV23701

Expression system

Mammalian Cells

Species reactivity

Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clonality

Monoclonal

Target

Virion infectivity factor, Vif, SOR protein, p17, p7, vif

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P12504

Applications

ELISA, IP

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1421

Data Image
  • SDS-PAGE
    SDS PAGE for HIV-1 Vif/SOR protein Antibody
References

HIV-1 Vif suppresses antiviral immunity by targeting STING. PMID: 34811497

The structural basis for HIV-1 Vif antagonism of human APOBEC3G. PMID: 36754086

Demystifying Cell Cycle Arrest by HIV-1 Vif. PMID: 33478820

Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein. PMID: 33916704

HIV-1 Vif Gained Breadth in APOBEC3G Specificity after Cross-Species Transmission of Its Precursors. PMID: 34908448

HIV-1 Vif, APOBEC, and intrinsic immunity. PMID: 18577210

HIV-1 Vif: HIV's weapon against the cellular defense factor APOBEC3G. PMID: 16250885

HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors. PMID: 20538015

HIV-1 Escape from Small-Molecule Antagonism of Vif. PMID: 30808702

Structural disorder in the HIV-1 Vif protein and interaction-dependent gain of structure. PMID: 20450485

HIV-1: fifteen proteins and an RNA. PMID: 9759480

The Vif protein of human immunodeficiency virus type 1 (HIV-1): enigmas and solutions. PMID: 14754418

Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s. PMID: 32893454

Antiviral roles of APOBEC proteins against HIV-1 and suppression by Vif. PMID: 19669862

The role of Vif during HIV-1 infection: interaction with novel host cellular factors. PMID: 12600646

The role of Vif oligomerization and RNA chaperone activity in HIV-1 replication. PMID: 22728817

The viral infectivity factor (Vif) of HIV-1 unveiled. PMID: 15177194

Recent insights into HIV-1 Vif. PMID: 15245742

Running loose or getting lost: how HIV-1 counters and capitalizes on APOBEC3-induced mutagenesis through its Vif protein. PMID: 23202519

HIV-1 Vif adaptation to human APOBEC3H haplotypes. PMID: 24139399

The Structural Interface between HIV-1 Vif and Human APOBEC3H. PMID: 28031368

HIV-1 Vif N-terminal motif is required for recruitment of Cul5 to suppress APOBEC3. PMID: 24422669

Blocking HIV-1 Vif restores a natural mechanism of intracellular antiviral defense. PMID: 15578976

A novel HIV-1 inhibitor that blocks viral replication and rescues APOBEC3s by interrupting vif/CBFβ interaction. PMID: 32817167

Genetic Diversity of HIV-1 Gene vif Among Treatment-Naive Brazilians. PMID: 28443724

Is the tryptophan codon of gene vif the Achilles' heel of HIV-1? PMID: 32570272

HIV-1 and HIV-2 Vif interact with human APOBEC3 proteins using completely different determinants. PMID: 24942576

Molecular Characterization of Mexican HIV-1 Vif Sequences. PMID: 26529466

Host AKT-mediated phosphorylation of HIV-1 accessory protein Vif potentiates infectivity via enhanced degradation of the restriction factor APOBEC3G. PMID: 35259395

[Research methods of anti-HIV-1 inhibitors targeting at Vif-APOBEC3G axis]. PMID: 21710755

Multiple lysines combined in HIV-1 Vif determines the responsiveness to CBF-β. PMID: 25582776

Identification of HIV-1 Vif regions required for CBF-β interaction and APOBEC3 suppression. PMID: 24810617

HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay. PMID: 21279453

Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis. PMID: 24418540

New insights into the role of Vif in HIV-1 replication. PMID: 15168739

HIV-1 subtype variability in Vif derived from molecular clones affects APOBEC3G-mediated host restriction. PMID: 23689841

APOBEC3F determinants of HIV-1 Vif sensitivity. PMID: 25142588

Cell-dependent function of HIV-1 Vif for virus replication (Review). PMID: 10202177

HIV-1 Vif promotes the formation of high molecular mass APOBEC3G complexes. PMID: 18023836

Complex Relationships between HIV-1 Integrase and Its Cellular Partners. PMID: 36293197

The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif autophagic degradation. PMID: 26105074

HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. PMID: 14527406

HIV-1 Vif inhibits G to A hypermutations catalyzed by virus-encapsidated APOBEC3G to maintain HIV-1 infectivity. PMID: 25304135

Small-molecule inhibition of HIV-1 Vif. PMID: 18806783

HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1. PMID: 31145054

HIV-1 accessory proteins: Vpu and Vif. PMID: 24158820

Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein. PMID: 25724652

Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction. PMID: 24225024

Role of vif during packing of the core of HIV-1. PMID: 8184544

Identification of an HIV-1 replication inhibitor which rescues host restriction factor APOBEC3G in Vif-APOBEC3G complex. PMID: 26241003

Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function. PMID: 28302150

Conserved Interaction of Lentiviral Vif Molecules with HIV-1 Gag and Differential Effects of Species-Specific Vif on Virus Production. PMID: 28122978

HIV-1 Vif and APOBEC3G: multiple roads to one goal. PMID: 15383144

Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest. PMID: 32292164

APOBEC3G impairs the multimerization of the HIV-1 Vif protein in living cells. PMID: 23576497

Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 Vif. PMID: 20147392

Phosphorylation of Vif and its role in HIV-1 replication. PMID: 8626571

A naturally occurring Vif mutant (I107T) attenuates anti-APOBEC3G activity and HIV-1 replication. PMID: 23707381

Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling. PMID: 32847850

The activity spectrum of Vif from multiple HIV-1 subtypes against APOBEC3G, APOBEC3F, and APOBEC3H. PMID: 22013041

Determinants of efficient degradation of APOBEC3 restriction factors by HIV-1 Vif. PMID: 25275135

HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. PMID: 14528301

Indolizine derivatives as HIV-1 VIF-ElonginC interaction inhibitors. PMID: 23405965

HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation. PMID: 18082865

Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication. PMID: 12039955

MDM2 is a novel E3 ligase for HIV-1 Vif. PMID: 19128510

Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H Haplotype I. PMID: 36851677

Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G. PMID: 18501607

Dispersed and conserved hydrophobic residues of HIV-1 Vif are essential for CBFβ recruitment and A3G suppression. PMID: 24352440

Functional analysis of HIV-1 vif genes derived from Japanese long-term nonprogressors and progressors for AIDS. PMID: 15374001

ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction. PMID: 25901786

Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes. PMID: 20833716

Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradation. PMID: 15374000

Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G. PMID: 21228271

A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity. PMID: 19939923

An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation. PMID: 27825797

Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif. PMID: 15993456

A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins. PMID: 15152192

Human immunodeficiency virus 1 (HIV-1) virion infectivity factor (Vif) is part of reverse transcription complexes and acts as an accessory factor for reverse transcription. PMID: 18037155

Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation. PMID: 15989462

Unusual substitutions in HIV-1 vif from children infected perinatally without progression to AIDS for more than 8 years without therapy. PMID: 23080486

Induction of heat-shock protein 70 by prostaglandin A₁ inhibits HIV-1 Vif-mediated degradation of APOBEC3G. PMID: 23831493

Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants. PMID: 7745702

Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif. PMID: 23988114

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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Anti-HIV-1 Vif/SOR protein Nanobody (SAA1421) [RVV23701]
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