Catalog No.
RVV19304
Expression system
Mammalian Cells
Species reactivity
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Target
Gag-Pol polyprotein, Pr160Gag-Pol, Matrix protein p17, MA, Capsid protein p24, CA, Spacer peptide 1, SP1, p2, Nucleocapsid protein p7, NC, Transframe peptide, TF, p6-pol, p6*, Protease, 3.4.23.16, PR, Retropepsin, Reverse transcriptase/ribonuclease H, 2.7.7.49, 2.7.7.7, 3.1.26.13, Exoribonuclease H, 3.1.13.2, p66 RT, p51 RT, p15, Integrase, IN, 2.7.7.-, 3.1.-.-, gag-pol
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P03367
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
M33
HIV-1 Matrix Protein p17 and its Receptors. PMID: 26302809
The HIV-1 Matrix Protein p17 Does Cross the Blood-Brain Barrier. PMID: 34668776
HIV-1 matrix protein p17: a candidate antigen for therapeutic vaccines against AIDS. PMID: 20816696
High expression of HIV-1 matrix protein p17 in both lymphoma and lymph node tissues of AIDS patients. PMID: 35939971
Functions of the HIV-1 matrix protein p17. PMID: 16608119
Maturation of the matrix and viral membrane of HIV-1. PMID: 34353956
HIV-1 mutants expressing B cell clonogenic matrix protein p17 variants are increasing their prevalence worldwide. PMID: 35763571
HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2. PMID: 22904195
Role of Autophagy in HIV-1 Matrix Protein p17-Driven Lymphangiogenesis. PMID: 28592537
The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2. PMID: 24736615
Total chemical synthesis of N-myristoylated HIV-1 matrix protein p17: structural and mechanistic implications of p17 myristoylation. PMID: 15280532
HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders. PMID: 28871125
HIV-1 matrix protein p17 promotes lymphangiogenesis and activates the endothelin-1/endothelin B receptor axis. PMID: 24482377
HIV-1 matrix protein p17 and its variants promote human triple negative breast cancer cell aggressiveness. PMID: 29021819
Role of HIV-1 matrix protein p17 variants in lymphoma pathogenesis. PMID: 26578780
Cellular aspartyl proteases promote the unconventional secretion of biologically active HIV-1 matrix protein p17. PMID: 27905556
The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes. PMID: 22558273
The HIV-1 matrix protein p17 activates the transcription factors c-Myc and CREB in human B cells. PMID: 20402410
Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion. PMID: 8659115
The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma. PMID: 26469385
Angiogenic, lymphangiogenic and adipogenic effects of HIV-1 matrix protein p17. PMID: 26333571
Role of Autophagy in Von Willebrand Factor Secretion by Endothelial Cells and in the In Vivo Thrombin-Antithrombin Complex Formation Promoted by the HIV-1 Matrix Protein p17. PMID: 32188077
Heparin and heparan sulfate proteoglycans promote HIV-1 p17 matrix protein oligomerization: computational, biochemical and biological implications. PMID: 31673058
In-depth analysis of compartmentalization of HIV-1 matrix protein p17 in PBMC and plasma. PMID: 28072889
Expression of HIV-1 matrix protein p17 and association with B-cell lymphoma in HIV-1 transgenic mice. PMID: 27799525
A CXCR1 haplotype hampers HIV-1 matrix protein p17 biological activity. PMID: 25121556
Binding to PI(4,5)P2 is indispensable for secretion of B-cell clonogenic HIV-1 matrix protein p17 variants. PMID: 34273353
HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation. PMID: 22262769
Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants. PMID: 30248376
Flexible and rigid structures in HIV-1 p17 matrix protein monitored by relaxation and amide proton exchange with NMR. PMID: 24373876
Structure-function studies of the human immunodeficiency virus type 1 matrix protein, p17. PMID: 9094619
HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype. PMID: 18310327
Structural similarity between the p17 matrix protein of HIV-1 and interferon-gamma. PMID: 8065455
HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of transcriptional factor AP-1. PMID: 18042260
HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and counteracts IL-4 activity by binding to a cellular receptor. PMID: 12105273
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015. PMID: 18570590
HIV-1 matrix protein p17 prevents loss of CD28 expression during IL-2-induced maturation of naïve CD8(+) T cells. PMID: 21482826
HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production. PMID: 1457192
HIV-1 matrix protein p17 resides in cell nuclei in association with genomic RNA. PMID: 24456624
Synthetic HIV-1 matrix protein p17-based AT20-KLH therapeutic immunization in HIV-1-infected patients receiving antiretroviral treatment: A phase I safety and immunogenicity study. PMID: 23166320
Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists. PMID: 16713032
The HIV-1 matrix protein p17 can be efficiently delivered by intranasal route in mice using the TLR 2/6 agonist MALP-2 as mucosal adjuvant. PMID: 15134345
The central domain of the matrix protein of HIV-1: influence on protein structure and virus infectivity. PMID: 12542496
HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines. PMID: 32588322
Effects of HIV on the Tumor Microenvironment. PMID: 29664204
Characterization and epitope mapping of a panel of monoclonal antibodies against HIV-1 matrix protein. PMID: 27907055
Effect of Glu12-His89 Interaction on Dynamic Structures in HIV-1 p17 Matrix Protein Elucidated by NMR. PMID: 29571970
Unconventional secretion of viral proteins. PMID: 24732873
Detection of HIV-1 matrix protein p17 quasispecies variants in plasma of chronic HIV-1-infected patients by ultra-deep pyrosequencing. PMID: 26912608
Membrane Binding of HIV-1 Matrix Protein: Dependence on Bilayer Composition and Protein Lipidation. PMID: 16817760
HIV-1 matrix protein p17 modulates in vivo preactivated murine T-cell response and enhances the induction of systemic and mucosal immunity against intranasally co-administered antigens. PMID: 33467638
Oncogenic Effects of HIV-1 Proteins, Mechanisms Behind. PMID: 26057863
Long-lasting humoral immune response induced in HIV-1-infected patients by a synthetic peptide (AT20) derived from the HIV-1 matrix protein p17 functional epitope. PMID: 8654825
Refined solution structure of p17, the HIV matrix protein. PMID: 28747658
A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17. PMID: 26621736
Correction to Supporting Information for Dolcetti et al., Role of HIV-1 matrix protein p17 variants in lymphoma pathogenesis. PMID: 17210199
HIV-1 matrix protein: a mysterious regulator of the viral life cycle. PMID: 22705971
The HIV-1 matrix protein does not interact directly with the protein interactive domain of AP-3δ. PMID: 30100245
Cartilage oligomeric matrix protein is differentially expressed in human subcutaneous adipose tissue and regulates adipogenesis. PMID: 17411366
Regulating the functions of the HIV-1 matrix protein. PMID: 25950938
Lignin as immobilization matrix for HIV p17 peptide used in immunosensing. PMID: 37222611
Towards Novel HIV-1 Serodiagnostic Tests without Vaccine-Induced Seroreactivity. PMID: 12465460
HIV-1 replication. PMID: 25704763
A natural HIV p17 protein variant up-regulates the LMP-1 EBV oncoprotein and promotes the growth of EBV-infected B-lymphocytes: implications for EBV-driven lymphomagenesis in the HIV setting. PMID: 18553937
Solution X-ray scattering reveals a novel structure of calmodulin complexed with a binding domain peptide from the HIV-1 matrix protein p17. PMID: 8619916
Conservative hydrophobic interdomain contacts of IFN-gamma remain in P17 matrix protein of HIV-1. PMID: 27030269
Trimer Enhancement Mutation Effects on HIV-1 Matrix Protein Binding Activities. PMID: 18602957
Synthetic peptide AT20 coupled to KLH elicits antibodies against a conserved conformational epitope from a major functional area of the HIV-1 matrix protein p17. PMID: 8503172
Assembly of the matrix protein of simian immunodeficiency virus into virus-like particles. PMID: 9085253
Inhibition of early and late events of the HIV-1 replication cycle by cytoplasmic Fab intrabodies against the matrix protein, p17. PMID: 31375578
Heterogeneous Nuclear Ribonucleoprotein A1 and Lamin A/C Modulate Nucleocytoplasmic Shuttling of Avian Reovirus p17. PMID: 25900164
Cross-Reactivity Between Influenza Matrix- and HIV-1 P17-Specific CTL-A Large Cohort Study. PMID: 18225865
The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association. PMID: 1629961
The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions. PMID: 9123837
Pleiotropic mutations in the HIV-1 matrix protein that affect diverse steps in replication. PMID: 9514761
Membrane-induced alterations in HIV-1 Gag and matrix protein-protein interactions. PMID: 18947403
For research use only. Not for human or drug use.
