Anti-PRKCQ Polyclonal Antibody

Catalog No.

PHG02601

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PRKCQ (Phe380-Phe634).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

nPKC-theta, PRKCQ, PRKCT, Protein kinase C theta type

Purification

Purified by antigen affinity column.

Accession

Q04759

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

C-C motif chemokines ligand 7 contributes to metabolic dysfunction-associated steatotic liver disease by enabling redox-sensitive induction of hypermethylated in cancer 1., PMID:40157597

PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation., PMID:38513140

Black Ginseng Extract Exerts Potentially Anti-Asthmatic Activity by Inhibiting the Protein Kinase Cθ-Mediated IL-4/STAT6 Signaling Pathway., PMID:37569348

Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition., PMID:35484420

Pan-Cancer Study on Protein Kinase C Family as a Potential Biomarker for the Tumors Immune Landscape and the Response to Immunotherapy., PMID:35174160

Thrombospondin-1 aggravates colonic mucosal inflammatory injuries via promoting the differentiation of CD11c+ macrophages with lysosomal activity limited in colitis., PMID:35071432

Protein Kinase C Theta Modulates PCMT1 through hnRNPL to Regulate FOXP3 Stability in Regulatory T Cells., PMID:32592691

Cell-Penetrating Anti-Protein Kinase C Theta Antibodies Act Intracellularly to Generate Stable, Highly Suppressive Regulatory T Cells., PMID:32492367

NK Cell-Mediated Processing Of Chlamydia psittaci Drives Potent Anti-Bacterial Th1 Immunity., PMID:30886314

PKCθ utility in diagnosing c-KIT/DOG-1 double negative gastrointestinal stromal tumors., PMID:28915565

Intracellular Delivery of Anti-pPKCθ (Thr538) via Protein Transduction Domain Mimics for Immunomodulation., PMID:27633441

Ceramide inhibits PKCθ by regulating its phosphorylation and translocation to lipid rafts in Jurkat cells., PMID:26798039

Disease relevance of T11TS-induced T-cell signal transduction through the CD2-mediated calcineurin-NFAT pathway: Perspectives in glioma immunotherapy., PMID:26105805

Nesfatin-1 Suppresses Cardiac L-type Ca²⁺ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway., PMID:25997563

Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: involvement of protein kinase C-θ activation., PMID:25638159

IFNα signaling through PKC-θ is essential for antitumor NK cell function., PMID:25960930

B cells assist allograft rejection in the deficiency of protein kinase c-theta., PMID:23841454

Genome-wide association study of antibody response to smallpox vaccine., PMID:22542470

Pathophysiology of rheumatoid arthritis., PMID:21427580

DOG1 utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration., PMID:21400668

CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation., PMID:21289089

Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells., PMID:21282629

Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour., PMID:20716167

T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling., PMID:20592275

Alteration of the PKC theta-Vav1 complex and phosphorylation of Vav1 in TCDD-induced apoptosis in the lymphoblastic T cell line, L-MAT., PMID:20561557

Widespread expression of PICOT in mouse and human tissues with predominant localization to epithelium., PMID:20498481

Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta., PMID:20498263

Aggregation of spectrin and PKCtheta is an early hallmark of fludarabine/mitoxantrone/dexamethasone-induced apoptosis in Jurkat T and HL60 cells., PMID:20058056

Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats., PMID:19801385

Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis., PMID:19644859

Protein kinase Ctheta focusing at the cSMAC is a consequence rather than cause of TCR signaling and is dependent on the MEK/ERK pathway., PMID:19414753

Deficiency of protein kinase C-theta facilitates tolerance induction., PMID:19307786

Impaired activation of platelets lacking protein kinase C-theta isoform., PMID:19164598

The expression pattern of PKCtheta in satellite cells of normal and regenerating muscle in the rat., PMID:18992015

A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection., PMID:18566417

Micropatterning of costimulatory ligands enhances CD4+ T cell function., PMID:18505845

A blocking anti-CD28-specific antibody induces long-term heart allograft survival by suppression of the PKC theta-JNK signal pathway., PMID:18408588

Characteristics of KIT-negative gastrointestinal stromal tumours and diagnostic utility of protein kinase C theta immunostaining., PMID:18381383

Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis., PMID:18250475

Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1., PMID:17478723

PKC-theta-deficient mice are protected from Th1-dependent antigen-induced arthritis., PMID:16849501

Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils., PMID:16622226

Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation"., PMID:16601177

Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina., PMID:16503160

Protein kinase C theta is not essential for T-cell-mediated clearance of murine gammaherpesvirus 68., PMID:15890920

Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases., PMID:15814670

Polyunsaturated fatty acids interfere with formation of the immunological synapse., PMID:15703198

Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes., PMID:15699116

SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1., PMID:15539155

Protein kinase C beta is dispensable for TCR-signaling., PMID:15163535

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