Anti-MDM2 Polyclonal Antibody

Catalog No.

PHF84501

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MDM2 (Asn3-Pro491).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

MDM2, Hdm2, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2, RING-type E3 ubiquitin transferase Mdm2, Double minute 2 protein, Oncoprotein Mdm2

Purification

Purified by antigen affinity column.

Accession

Q00987

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

The Intrabody Against Murine Double Minute 2 via a p53-Dependent Pathway Induces Apoptosis of Cancer Cell., PMID:40508092

3'UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells., PMID:40381037

Unraveling Venetoclax Resistance: Navigating the Future of HMA/Venetoclax-Refractory AML in the Molecular Era., PMID:40361510

Combined Chemotherapy-Immunotherapy for Advanced Biliary Tract Cancer (BTC): A Clinical, Genomic, and Biomarker Analysis., PMID:40167580

O-Cyanobenzaldehydes Irreversibly Modify Both Buried and Exposed Lysine Residues in Live Cells., PMID:40150802

Fc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cells., PMID:40108539

Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research., PMID:39804528

Tumor-derived CCL15 regulates RNA m6A methylation in cancer-associated fibroblasts to promote hepatocellular carcinoma growth., PMID:39734010

MDM2 drives resistance to Osimertinib by contextually disrupting FBW7-mediated destruction of MCL-1 protein in EGFR mutant NSCLC., PMID:39543744

NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes., PMID:39472976

IMP3, CDK4, MDM2 and β-catenin expression in Enchondroma and Central Chondrosarcoma: Diagnostic and prognostic utility., PMID:39368400

A metabolic crosstalk between liposarcoma and muscle sustains tumor growth., PMID:39266552

SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11-MDM2-p53 Pathway in Glioma., PMID:39258423

Tirbanibulin decreases cell proliferation and downregulates protein expression of oncogenic pathways in human papillomavirus containing HeLa cells., PMID:38967656

Optimizing drug combinations for T-PLL: restoring DNA damage and P53-mediated apoptotic responses., PMID:38941598

Revised Diagnosis From Histiocytic Neoplasm to Optic Chiasm Glioblastoma After Genetic Analysis., PMID:38926909

Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing Mitochondrial Disruption., PMID:38802154

TP53 Mutations in Acute Leukemias and Myelodysplastic Syndromes: Insights and Treatment Updates., PMID:38768424

HER3 (ERBB3) amplification in liposarcoma - a putative new therapeutic target?, PMID:38760830

Anticancer therapeutic strategies for targeting mutant p53-Y220C., PMID:38738269

Management of High-Risk Neuroblastoma with Soft-Tissue-Only Disease in the Era of Anti-GD2 Immunotherapy., PMID:38730688

Glioblastoma Therapy: Past, Present and Future., PMID:38473776

Comparative Expression Analysis of TP53 Tumor Suppressor and MDM2 Oncogene in Colorectal Adenocarcinoma., PMID:38434910

Alternative polyadenylation determines the functional landscape of inverted Alu repeats., PMID:38309276

Targeted inhibition of the ATR/CHK1 pathway overcomes resistance to olaparib and dysregulates DNA damage response protein expression in BRCA2MUT ovarian cancer cells., PMID:38114660

Immunoexpression of HER2 pathway related markers in HER2 invasive breast carcinomas treated with trastuzumab., PMID:37977031

Cell-Surface-Retained Peptide Additives for the Cytosolic Delivery of Functional Proteins., PMID:37906525

A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review., PMID:37735390

DNA-dependent protein kinase catalytic subunit binds to the transactivation domain 1 of NF-κB p65., PMID:37674974

Impact of Amplified Oncogenes on Salivary Gland Carcinomas., PMID:37671310

Emerging roles of Aurora-A kinase in cancer therapy resistance., PMID:37521867

SF3B1 Mutations Are Associated with Resistance to Non-Genotoxic MDM2 Inhibition in Chronic Lymphocytic Leukemia., PMID:37511096

Building on Foundations: Venetoclax-Based Combinations in the Treatment of Acute Myeloid Leukemia., PMID:37509251

GADD34 activates p53 and may have utility as a marker of atherosclerosis., PMID:37228401

Histological and biochemical evaluation of the effects of silver nanoparticles (AgNps) versus titanium dioxide nanoparticles (TiO2NPs) on rat parotid gland., PMID:37132546

Somatic alterations of TP53 and MDM2 associated with response to enfortumab vedotin in patients with advanced urothelial cancer., PMID:37091148

Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy., PMID:37024504

Role of p53 in breast cancer progression: An insight into p53 targeted therapy., PMID:36923534

Anti-leukemic effect of menthol, a peppermint compound, on induction of apoptosis and autophagy., PMID:36923503

ISG20L1 acts as a co-activator of DAPK1 in the activation of the p53-dependent cell death pathway., PMID:36855954

Comprehensive immunohistochemical analysis based on the origin of leiomyosarcoma., PMID:36734438

Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions., PMID:36697672

IHC expression of AKT in different grades of epithelial dysplasia: An in vitro study., PMID:36588841

Atezolizumab Plus Bevacizumab as First-line Treatment for Patients With Metastatic Nonsquamous Non-Small Cell Lung Cancer With High Tumor Mutation Burden: A Nonrandomized Controlled Trial., PMID:36520426

Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels., PMID:36358737

Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report., PMID:36246198

Effects of chloroquine and hydroxychloroquine on the sensitivity of pancreatic cancer cells to targeted therapies., PMID:36243652

CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis., PMID:36182968

Immunohistochemical Detection and Prognostic Significance of p53, Epidermal Growth Factor Receptor, Murine Double Minute 2, and Isocitrate Dehydrogenase 1 in Glioblastoma Multiforme Patients of Pakistan., PMID:36035640

Multiple Myeloma: Bioinformatic Analysis for Identification of Key Genes and Pathways., PMID:35958298

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