Catalog No.
YVV08901
Expression system
E. coli
Species
Human papillomavirus type 16
Protein length
His2-Pro98
Predicted molecular weight
24.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P03129
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein E7, E7
HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING. PMID: 31874109
Murine HPV16 E7-expressing transgenic skin effectively emulates the cellular and molecular features of human high-grade squamous intraepithelial lesions. PMID: 29807614
HPV16 AND EXPRESSION OF PROTEIN P16INK4A AND E7 ONCOPROTEIN IN COLORECTAL CARCINOMA. PMID: 35107499
Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice. PMID: 35089069
Evaluation of HPV16 E7 expression in head and neck carcinoma cell lines and clinical specimens. PMID: 33335126
Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer. PMID: 34971406
HPV16 E6 and E7 Oncoproteins Stimulate the Glutamine Pathway Maintaining Cell Proliferation in a SNAT1-Dependent Fashion. PMID: 36851539
The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells. PMID: 36847693
Modeling and Molecular Dynamics of the 3D Structure of the HPV16 E7 Protein and Its Variants. PMID: 33573298
HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells. PMID: 28720067
HPV 16 E7 alters translesion synthesis signaling. PMID: 36266721
A novel function of HPV16-E6/E7 in epithelial-mesenchymal transition. PMID: 23628416
Immunization of mice by the co-administration of codon-optimized HPV16 E7 and lL12 genes against HPV16-associated cervical cancer. PMID: 31004722
The Intracellular Delivery Of Anti-HPV16 E7 scFvs Through Engineered Extracellular Vesicles Inhibits The Proliferation Of HPV-Infected Cells. PMID: 31806970
HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. PMID: 25439690
The expression of Oct3/4A mRNA and not its isoforms is upregulated by the HPV16 E7 oncoprotein. PMID: 36378419
Significant growth inhibition by a bispecific affibody targeting oncoprotein E7 in both HPV16 and 18 positive cervical cancer in vitro and in vivo. PMID: 35245683
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China. PMID: 34217247
Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. PMID: 28786561
HPV16 oncogenes E6 or/and E7 may influence the methylation status of RASSFIA gene promoter region in cervical cancer cell line HT-3. PMID: 28260046
Epithelium Expressing the E7 Oncoprotein of HPV16 Attracts Immune-Modulatory Dendritic Cells to the Skin and Suppresses Their Antigen-Processing Capacity. PMID: 27031095
CUL2 overexpression driven by CUL2/E2F1/miR-424 regulatory loop promotes HPV16 E7 induced cervical carcinogenesis. PMID: 27153550
Apoptosis induced by an antagonist peptide against HPV16 E7 in vitro and in vivo via restoration of p53. PMID: 21475994
Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein. PMID: 33800513
Distinctive distribution of HPV16 E6 D25E and E7 N29S intratypic Asian variants in Korean commercial sex workers. PMID: 17311337
Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women. PMID: 23946477
HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia. PMID: 28451790
hnRNP G/RBMX enhances HPV16 E2 mRNA splicing through a novel splicing enhancer and inhibits production of spliced E7 oncogene mRNAs. PMID: 35357488
Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay. PMID: 35225653
Systematic Analysis of IL-1 Cytokine Signaling Suppression by HPV16 Oncoproteins. PMID: 36342298
Frequent presence of incomplete HPV16 E7 ORFs in lung carcinomas: memories of viral infection. PMID: 20850378
HPV16-transformed human keratinocytes depend on SIX1 expression for proliferation and HPV E6/E7 gene expression. PMID: 31425971
HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. PMID: 23592995
Disruption of HPV16-E7 by CRISPR/Cas system induces apoptosis and growth inhibition in HPV16 positive human cervical cancer cells. PMID: 25136604
The heterogeneous structural behavior of E7 from HPV16 revealed by NMR spectroscopy. PMID: 23940009
HnRNP D activates production of HPV16 E1 and E6 mRNAs by promoting intron retention. PMID: 35234917
Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription. PMID: 31915229
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway. PMID: 30410307
Human Papillomavirus E6/E7 and Long Noncoding RNA TMPOP2 Mutually Upregulated Gene Expression in Cervical Cancer Cells. PMID: 30728257
Diagnostic Utility of HPV16 E6 mRNA or E7 mRNA Quantitative Expression for Cervical Cells of Patients with Dysplasia and Carcinoma. PMID: 30056761
T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx. PMID: 16284959
Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors. PMID: 33485370
DNA Vaccine Encoding HPV16 Oncogenes E6 and E7 Induces Potent Cell-mediated and Humoral Immunity Which Protects in Tumor Challenge and Drives E7-expressing Skin Graft Rejection. PMID: 28166181
Identification of key amino acid residues that determine the ability of high risk HPV16-E7 to dysregulate major histocompatibility complex class I expression. PMID: 21321113
Detection of HPV E7 Transcription at Single-Cell Resolution in Epidermis. PMID: 29964033
Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. PMID: 25540383
HPV-16 E7 Interacts with the Endocytic Machinery via the AP2 Adaptor μ2 Subunit. PMID: 36255238
Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women. PMID: 31670402
Longitudinal Dynamics of HPV16 Antibodies in Saliva and Serum among Pregnant Women. PMID: 36423177
Cellular Functions of HPV16 E5 Oncoprotein during Oncogenic Transformation. PMID: 33106372
A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer. PMID: 32151670
A Drosophila model of HPV16-induced cancer reveals conserved disease mechanism. PMID: 36508448
Immunocytochemical detection of HPV16 E7 in cervical smear. PMID: 18059138
Identification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells. PMID: 27457222
Nuclear import of high risk HPV16 E7 oncoprotein is mediated by its zinc-binding domain via hydrophobic interactions with Nup62. PMID: 24074597
HPV-inactive cell populations arise from HPV16-transformed human keratinocytes after p53 knockout. PMID: 33321328
Fused toes homolog, a potential molecular regulator of human papillomavirus type 16 E6 and E7 oncoproteins in cervical cancer. PMID: 35421154
Monitoring HPV-16 E7 phosphorylation events. PMID: 28126639
Fungal mannosylation enhances human papillomavirus 16 E7 therapeutic immunity against TC-1 tumors. PMID: 29115562
Carboplatin/paclitaxel, E7-vaccination and intravaginal CpG as tri-therapy towards efficient regression of genital HPV16 tumors. PMID: 31060612
SOX2 as a New Regulator of HPV16 Transcription. PMID: 28678184
Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer. PMID: 21654689
The expression of human papillomavirus type 16 (HPV16 E7) induces cell cycle arrest and apoptosis in radiation and hypoxia resistant glioblastoma cells. PMID: 21850378
Expression and purification of His-tagged HPV16 E7 protein active in pRb binding. PMID: 16814565
Genetic variation in the E6 and E7 genes of human papillomavirus type 16 in northeastern Argentina. PMID: 34569642
Genetic Variability in the E6, E7, and L1 Genes of Human Papillomavirus Types 16 and 18 among Women in Saudi Arabia. PMID: 36680149
Human papillomavirus 16-encoded E7 protein inhibits IFN-γ-mediated MHC class I antigen presentation and CTL-induced lysis by blocking IRF-1 expression in mouse keratinocytes. PMID: 23956301
Transforming Properties of Beta-3 Human Papillomavirus E6 and E7 Proteins. PMID: 32669468
Human Papillomavirus 16 E6 and E7 Oncoproteins Alter the Abundance of Proteins Associated with DNA Damage Response, Immune Signaling and Epidermal Differentiation. PMID: 36016386
Identification of novel E6-E7 sequence variants of human papillomavirus 16. PMID: 23208280
Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer. PMID: 27044426
Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes. PMID: 21865393
The HPV16 oncogenes cause aberrant stem cell mobilization. PMID: 23664148
For research use only. Not for human or drug use.
