Catalog No.
RXX00301
Expression system
Mammalian Cells
Species reactivity
Clostridioides difficile (Peptoclostridium difficile)
Host species
Alpaca
Isotype
VHH-8His-Cys-tag
Clonality
Monoclonal
Target
Toxin B, 3.4.22.-, Glucosyltransferase TcdB, 2.4.1.-, tcdB, toxB,Clostridium difficile Toxin
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
P18177
Applications
ELISA, SPR, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1173
Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile., PMID:38923049
Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development., PMID:34862749
Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains., PMID:30540857
Intravenous adenovirus expressing a multi-specific, single-domain antibody neutralizing TcdA and TcdB protects mice from Clostridium difficile infection., PMID:27502696
Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies., PMID:26573738
Single domain antibody coated gold nanoparticles as enhancer for Clostridium difficile toxin detection by electrochemical impedance immunosensors., PMID:25460611
Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis., PMID:25404023
A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice., PMID:24683195
Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile., PMID:24311789
A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders., PMID:22490957
Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives., PMID:22069622