Anti-Clostridioides difficile Toxin B/tcdB Nanobody (SAA1173)

Catalog No.

RXX00301

Expression system

Mammalian Cells

Species reactivity

Clostridioides difficile (Peptoclostridium difficile)

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clonality

Monoclonal

Target

Toxin B, 3.4.22.-, Glucosyltransferase TcdB, 2.4.1.-, tcdB, toxB,Clostridium difficile Toxin

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P18177

Applications

ELISA, SPR, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1173

Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile., PMID:38923049

Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development., PMID:34862749

Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains., PMID:30540857

Intravenous adenovirus expressing a multi-specific, single-domain antibody neutralizing TcdA and TcdB protects mice from Clostridium difficile infection., PMID:27502696

Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies., PMID:26573738

Single domain antibody coated gold nanoparticles as enhancer for Clostridium difficile toxin detection by electrochemical impedance immunosensors., PMID:25460611

Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis., PMID:25404023

A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice., PMID:24683195

Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile., PMID:24311789

A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders., PMID:22490957

Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives., PMID:22069622

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