The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets. PMID: 28823569
Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. PMID: 10451482
Human papillomavirus type 16 E6 proteins with glycine substitution for cysteine in the metal-binding motif. PMID: 1660194
Human papillomavirus type 16 sequence variants: identification by E6 and L1 lineage-specific hybridization. PMID: 8968874
The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300. PMID: 10487758
Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. PMID: 10438818
Splice sites of human papillomavirus type 16 E6 gene or heterologous gene required for transformation by E7 and accumulation of E7 RNA. PMID: 8636718
Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors. PMID: 14968115
The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals. PMID: 10364340
Expression of human papillomavirus type 16 E6-E7 open reading frame varies quantitatively in biopsy tissue from different grades of cervical intraepithelial neoplasia. PMID: 7615724
Telomerase activation by the E6 gene product of human papillomavirus type 16. PMID: 8598912
Genetic variability and lineage phylogeny of human papillomavirus type-16 and -53 based on the E6, E7, and L1 genes in Southwest China. PMID: 27450917
Mutational analysis of human papillomavirus type 16 E6 protein: transforming function for human cells and degradation of p53 in vitro. PMID: 7571423
Genetic diversity of human papillomavirus type 16 E6, E7, and L1 genes in Italian women with different grades of cervical lesions. PMID: 19626616
Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins. PMID: 1321290
Equine papillomavirus type 2: An equine equivalent to human papillomavirus 16? PMID: 28720295
Biologic activity of human papillomavirus type 16 E6/E7 cDNA clones isolated from SiHa cervical carcinoma cell line. PMID: 7483285
E6 and E7 variants of human papillomavirus-16 and -52 in Japan, the Philippines, and Vietnam. PMID: 23588734
Human papillomavirus type 16 E6 variants in cervical carcinoma: relationship to host genetic factors and clinical parameters. PMID: 10567656
Human papillomavirus type 16/18 oncoproteins: potential therapeutic targets in non-smoking associated lung cancer. PMID: 23317184
A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions. PMID: 21123374
Cervical/vaginal dysplasias of transgenic mice harbouring human papillomavirus type 16 E6-E7 genes. PMID: 7964615
Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells. PMID: 11287601
Persistence of human papillomavirus type 16 infection is associated with lack of cytotoxic T lymphocyte response to the E6 antigens. PMID: 10915094
Oncogenic human papillomavirus (HPV) type distribution and HPV type 16 E6 variants in two Spanish population groups with different levels of HPV infection risk. PMID: 16597872
Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes. PMID: 1326671
The large and small isoforms of human papillomavirus type 16 E6 bind to and differentially affect procaspase 8 stability and activity. PMID: 17267478
Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective. PMID: 9032384
The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture. PMID: 1651408
Human papillomavirus type 16 E6 protein up-regulates the expression of the high mobility group protein HMG-I(Y) gene in mouse 10T1/2 cells. PMID: 8806179
Human papillomavirus 16 E6/E7 transcript and E2 gene status in patients with cervical neoplasia. PMID: 15230643
Antibodies against human papillomavirus (HPV) type 16 and 18 E2, E6 and E7 proteins in sera: correlation with presence of papillomavirus DNA. PMID: 11745939
Absence of human papillomavirus type 16 E6 transcripts in HPV 16-infected, cytologically normal cervical scrapings. PMID: 8228915
The E6 gene of human papillomavirus type 16 is sufficient for transformation of baby rat kidney cells in cotransfection with activated Ha-ras. PMID: 8184549
Use of antibodies against a synthetic peptide of the E6 protein of human papillomavirus (HPV) type 16 for the diagnosis of genital HPV lesions. PMID: 8384016
Can a test for E6/E7 transcripts of human papillomavirus type 16 serve as a diagnostic tool for the detection of micrometastasis in cervical cancer? PMID: 7622311
The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. PMID: 10944189
Human papillomavirus type 16 E6, E7, and L1 variants in cervical cancer in Indonesia, Suriname, and The Netherlands. PMID: 15297193
Analysis of human papillomavirus type 16 E6-E7 transcription in cervical carcinomas and normal cervical epithelium using the polymerase chain reaction. PMID: 1695672
A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA. PMID: 14645924
Expression and localization of human papillomavirus type 16 E6 and E7 open reading frame proteins in human epidermal keratinocyte. PMID: 8009891
Serologic response to the E4, E6, and E7 proteins of human papillomavirus type 16 in pregnant women. PMID: 9500500
Variants of the long control region and the E6 oncogene in European human papillomavirus type 16 isolates: implications for cervical disease. PMID: 11870518
Translation of the human papillomavirus type 16 E7 oncoprotein from bicistronic mRNA is independent of splicing events within the E6 open reading frame. PMID: 7474122
Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells. PMID: 8384359
Absence of antibody against human papillomavirus type 16 E6 and E7 in patients with cervical cancer is independent of sequence variations. PMID: 10783118
Mechanism of translation of the bicistronic mRNA encoding human papillomavirus type 16 E6-E7 genes. PMID: 7931152
Leaky scanning is the predominant mechanism for translation of human papillomavirus type 16 E7 oncoprotein from E6/E7 bicistronic mRNA. PMID: 10906182
Identification and characterization of a cluster of transcription start sites located in the E6 ORF of human papillomavirus type 16. PMID: 14573795
The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere length. PMID: 9148955
The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability. PMID: 12460929
Human papillomavirus type 16 variant lineages in United States populations characterized by nucleotide sequence analysis of the E6, L2, and L1 coding segments. PMID: 7494284
Quantitative detection of spliced E6-E7 transcripts of human papillomavirus type 16 in cervical premalignant lesions. PMID: 1653501
Purification and biophysical characterization of a minimal functional domain and of an N-terminal Zn2+-binding fragment from the human papillomavirus type 16 E6 protein. PMID: 11170444
Immunization against human papillomavirus type 16 tumor cells with recombinant vaccinia viruses expressing E6 and E7. PMID: 1847269
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. PMID: 2476573
The biochemical and biological functions of human papillomavirus type 16 E5 protein. PMID: 12898324
Diversity of cervicovaginal human papillomavirus (HPV) genotypes and naturally occurring E6/E7 DNA polymorphisms of HPV-16 in Ghana. PMID: 37179021
The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth. PMID: 18160445
Detection of human papillomavirus type 16 E6/E7 oncogene transcripts in dysplastic and nondysplastic cervical scrapes by nested RT-PCR. PMID: 9600817
Differential splicing of E6 within human papillomavirus type 18 variants and functional consequences. PMID: 16099904
The identification of a conserved binding motif within human papillomavirus type 16 E6 binding peptides, E6AP and E6BP. PMID: 9472622
Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells. PMID: 8551603
Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatedness. PMID: 29281732
Epidermal growth factor (EGF) elicits down-regulation of human papillomavirus type 16 (HPV-16) E6/E7 mRNA at the transcriptional level in an EGF-stimulated human keratinocyte cell line: functional role of EGF-responsive silencer in the HPV-16 long control region. PMID: 1848315
Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity. PMID: 1318401
Analysis of human papillomavirus type-16 variants in Italian women with cervical intraepithelial neoplasia and cervical cancer. PMID: 15258977
Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells. PMID: 3038534
Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7. PMID: 2536119
ErbB-2 receptor cooperates with E6/E7 oncoproteins of HPV type 16 in breast tumorigenesis. PMID: 18156804
Immune response to human papillomavirus type 16 E6 gene in a live vaccinia vector. PMID: 7509369
Application of the NASBA nucleic acid amplification method for the detection of human papillomavirus type 16 E6-E7 transcripts. PMID: 7559859
p53-Dependent and -independent transactivation by the E6 protein of human papillomavirus type 16. PMID: 8601782
Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells. PMID: 7707525
Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. PMID: 7878034
Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation. PMID: 8794343
Signals that dictate nuclear localization of human papillomavirus type 16 oncoprotein E6 in living cells. PMID: 14645580
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