Catalog No.
RHD99601
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Alpaca
Isotype
VHH-8His-Cys-tag
Clonality
Monoclonal
Target
GPR183, G-protein coupled receptor 183, hEBI2, Epstein-Barr virus-induced G-protein coupled receptor 2, EBI2, EBV-induced G-protein coupled receptor 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
P32249
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0953
The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases., PMID:40307944
The role of orphan G protein-coupled receptors in pain., PMID:38590871
Single-cell transcriptomics reveals tumor-infiltrating B cell function after neoadjuvant pembrolizumab and chemotherapy in non-small cell lung cancer., PMID:37931147
G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kδi dual therapy., PMID:37153563
A dietary cholesterol by-product regulates intestinal IgA secretion via GPR183., PMID:36807643
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells., PMID:36658240
Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients., PMID:35875859
Structures of EBI2 shed light on the treatment of autoimmune diseases., PMID:35803240
Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials., PMID:35674978
Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response., PMID:35537452
GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity., PMID:35159303
EBI2-expressing B cells in neuromyelitis optica spectrum disorder with AQP4-IgG: Association with acute attacks and serum cytokines., PMID:34229205
The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection., PMID:32411130
EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes., PMID:29374507
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation., PMID:29343433
EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination., PMID:29246262
EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis., PMID:28052250
Chronic airway inflammation provides a unique environment for B cell activation and antibody production., PMID:28000955
The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages., PMID:27166278
EBI2 regulates intracellular signaling and migration in human astrocyte., PMID:25297897
EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture., PMID:23682316
The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells., PMID:23502855
B cell localization: regulation by EBI2 and its oxysterol ligand., PMID:23481574
Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression., PMID:23473835
EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues., PMID:21844396
Oxysterols direct immune cell migration via EBI2., PMID:21796212
Oxysterols direct B-cell migration through EBI2., PMID:21796211
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist., PMID:21673108
Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses., PMID:20508253
Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses., PMID:19615922
EBI2 mediates B cell segregation between the outer and centre follicle., PMID:19597478
Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist., PMID:18628402