Catalog No.
RHB90002
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Alpaca
Isotype
VHH-8His-Cys-tag
Clonality
Monoclonal
Target
CPAMD4, C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
P01031
Applications
BIF, ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1365
Differences in complement activation of serum-resistant and serum-sensitive Klebsiella pneumoniae isolates., PMID:40424786
A new treatment for canine B-cell lymphoma based on a recombinant single-domain antibody immunotoxin derived from Pseudomonas aeruginosa exotoxin A., PMID:40256602
GRP78 Nanobody-Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy., PMID:40135833
Expression Analysis of Heavy-Chain-Only Antibodies in Cloudy Catshark and Japanese Bullhead Shark., PMID:39852530
C5 complement inhibition versus FcRn modulation in generalised myasthenia gravis., PMID:39798960
Characteristics and Genomic Localization of Nurse Shark (Ginglymostoma cirratum) IgNAR., PMID:39684588
Designing and bioengineering of CDRs with higher affinity against receptor-binding domain (RBD) of SARS-CoV-2 Omicron variant., PMID:39675603
Coronavirus Disease 2019-Associated Thrombotic Microangiopathy: A Single-Center Experience., PMID:39596538
Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration., PMID:38142486
The solution structure of the heavy chain-only C5-Fc nanobody reveals exposed variable regions that are optimal for COVID-19 antigen interactions., PMID:37838175
Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies., PMID:37356719
Rabbit derived VL single-domains as promising scaffolds to generate antibody-drug conjugates., PMID:36964198
VH-Based Mini Q-Body: A Novel Quench-Based Immunosensor., PMID:36850849
Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging., PMID:36173177
Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity., PMID:35935935
[The frontline of TMA management]., PMID:35662172
Multifaceted Activities of Seven Nanobodies against Complement C4b., PMID:35428691
Cost analysis of the impact of caplacizumab in the treatment of acquired thrombotic thrombocytopenic purpura from a US hospital perspective., PMID:34643472
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19., PMID:34552091
Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies., PMID:33671302
A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity., PMID:32938727
An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase., PMID:32769120
A C3-specific nanobody that blocks all three activation pathways in the human and murine complement system., PMID:32376685
A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein., PMID:30555486
Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures., PMID:28994409
Specific detection of foot-and-mouth disease serotype Asia 1 virus by carboxyl-magnetic beads conjugated with single-domain antibody., PMID:26369792
For research use only. Not for human or drug use.
