Catalog No.
PHD19401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD127/IL7R (Lys266-Gln459).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
IL7R,Interleukin-7 receptor subunit alpha,IL-7R-alpha,IL-7 receptor subunit alpha,CD127,CDw127,IL-7R subunit alpha,IL-7RA
Purification
Purified by antigen affinity column.
Accession
P16871
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Terminal Effector CD8 T Cells Defined by an IKZF2(+)IL-7R(-) Transcriptional Signature Express FcgammaRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity. PMID: 31519862
Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response. PMID: 25604867
Nivolumab and ipilimumab are associated with distinct immune landscape changes and response-associated immunophenotypes. PMID: 32369447
Interleukin 7 receptor alpha as a potential therapeutic target in transplantation. PMID: 19585222
The suppressive effect on CD4 T cell alloresponse against endothelial HLA-DR via PD-L1 induced by anti-A/B ligation. PMID: 32578199
Elucidation of the Effects of a Current X-SCID Therapy on Intestinal Lymphoid Organogenesis Using an In Vivo Animal Model. PMID: 32017983
Combination of CD4(+)CD25(+)CD127(-) regulatory T cells with MLC-BE and BE-Ab2: an efficient evaluation of the therapy of paternal lymphocyte induced immunization in unexplained recurrent spontaneous abortion patients. PMID: 26097590
CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes. PMID: 33301420
Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Rα-Fc chimera. PMID: 24512738
IL-23 and PSMA-targeted duo-CAR T cells in Prostate Cancer Eradication in a preclinical model. PMID: 31937346
Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. PMID: 16785889
[Epidermotropic T cell lymphomas as models for tumor progression]. PMID: 16457762
IL-7 suppresses macrophage autophagy and promotes liver pathology in Schistosoma japonicum-infected mice. PMID: 29566311
Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma. PMID: 16322312
Anti-IL-7 receptor-alpha reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. PMID: 22733769
IL-7 Mediated Homeostatic Expansion of Human CD4+CD25+FOXP3+ Regulatory T Cells After Depletion With Anti-CD25 Monoclonal Antibody. PMID: 27306531
Multiple sclerosis treatment effects on plasma cytokine receptor levels. PMID: 28941836
IL-2/IL-2 antibody immune complex regulates HSV-induced inflammation through induction of IL-2 receptor alpha, beta, and gamma in a mouse model. PMID: 26213097
Decidual CD4+CD25+CD127dim/- regulatory T cells in patients with unexplained recurrent spontaneous miscarriage. PMID: 21130556
Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection. PMID: 14962198
TGF-beta(1) and contact mediated suppression by CD4(+)CD25(+)CD127(-) T regulatory cells of patients with self-limiting hepatitis E. PMID: 27720959
Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation. PMID: 23301543
B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage. PMID: 16323425
[Chromatin dynamics in gene rearrangement]. PMID: 16613168
Diphtheria toxin-based receptor-specific chimaeric toxins as targeted therapies. PMID: 8822152
Peripheral imbalanced TFH/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset. PMID: 29882478
Engagement of IL-1 receptor accessory protein (IL-1RAcP) with the monoclonal antibody AY19 provides co-activating signals and prolongs the CD2-induced proliferation of peripheral blood lymphocytes. PMID: 21600927
Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection. PMID: 12457615
Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera. PMID: 18589435
In-vitro inhibition of IFNgamma+ iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function. PMID: 22905732
Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells. PMID: 23280063
Therapy with anti-TNFalpha antibody enhances number and function of Foxp3(+) regulatory T cells in inflammatory bowel diseases. PMID: 20848510
B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage. PMID: 31628339
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity. PMID: 30670441
Alemtuzumab mediates the CD39+ T-regulatory cell response via CD23+ macrophages. PMID: 33306219
Decline of programmed death-1-positive circulating T regulatory cells predicts more favourable clinical outcome of patients with melanoma under immune checkpoint blockade. PMID: 31361026
The role of the preBCR, the interleukin-7 receptor, and homotypic interactions during B-cell development. PMID: 10933590
[Role of circulating T follicular helper subsets and T follicular helper effector memory cells in systemic lupus erythematosus]. PMID: 30669756
Autosomal primary immunodeficiencies affecting human bone marrow B-cell differentiation. PMID: 11213811
Interleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial-Mesenchymal Transition. PMID: 31061414
IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates. PMID: 30367166
Accumulation of memory precursor CD8 T cells in regressing tumors following combination therapy with vaccine and anti-PD-1 antibody. PMID: 24728077
Pre-B and pre-T-cell receptors: conservation of strategies in regulating early lymphocyte development. PMID: 10933593
IgH DJ rearrangements within T-ALL correlate with cCD79a expression, an immature/TCRgammadelta phenotype and absence of IL7Ralpha/CD127 expression. PMID: 15483677
Elevated IFN-alpha/beta levels in a streptozotocin-induced type I diabetic mouse model promote oxidative stress and mediate depletion of spleen-homing CD8+ T cells by apoptosis through impaired CCL21/CCR7 axis and IL-7/CD127 signaling. PMID: 26192098
Dysregulation of Circulating Tfr/Tfh Ratio in Primary biliary cholangitis. PMID: 28941291
Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation. PMID: 31406267
Expression of the IL-7 receptor alpha-chain is down regulated on the surface of CD4 T-cells by the HIV-1 Tat protein. PMID: 25333710
Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. PMID: 12209648
IL-7 Induces an Epitope Masking of gammac Protein in IL-7 Receptor Signaling Complex. PMID: 28127156
Co-transplantation of human fetal thymus, bone and CD34(+) cells into young adult immunodeficient NOD/SCID IL2Rgamma(null) mice optimizes humanized mice that mount adaptive antibody responses. PMID: 25725428
For research use only. Not for human or drug use.
