Catalog No.
PHK76201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human HES5 (Met1-Arg121).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
BHLHB38, Transcription factor HES-5, Class B basic helix-loop-helix protein 38, bHLHb38, Hairy and enhancer of split 5, HES5
Purification
Purified by antigen affinity column.
Accession
Q5TA89
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Pancreatic-Like Cells Derived From Mouse Embryonic Stem Cells Are Regulated by Pdx1 Involving the Notch Pathway., PMID:35695761
Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression., PMID:32650029
The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone., PMID:29037852
A Brief Report of Immunohistochemical Markers to Identify Aggressive Hepatoblastoma., PMID:28187036
Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis., PMID:27564686
Effect of IL-17 monoclonal antibody Secukinumab combined with IL-35 blockade of Notch signaling pathway on the invasive capability of hepatoma cells., PMID:27420998
Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina., PMID:26116667
Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition., PMID:26115193
Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice., PMID:26034172
Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12, and 13, and the HLA class II region., PMID:23460240
Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants., PMID:23042297
Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells., PMID:22842086
Glycogen synthase kinase-3 inhibition promotes proliferation and neuronal differentiation of human-induced pluripotent stem cell-derived neural progenitors., PMID:22642687
A monoclonal antibody against human Notch1 ligand-binding domain depletes subpopulation of putative breast cancer stem-like cells., PMID:22075160
Immunohistochemical expression of Notch signaling in the lining epithelium of periapical cysts., PMID:21238798
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors., PMID:20161710
Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells., PMID:19682396
Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1., PMID:19598246
Molecular characterization of human retinal progenitor cells., PMID:19553622
The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina., PMID:19490914
Notch signaling is required for lateral induction of Jagged1 during FGF-induced lens fiber differentiation., PMID:19481073
BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage., PMID:19074416
Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice., PMID:18950867
Down-regulation of Notch signaling during corneal epithelial proliferation., PMID:18552977
ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor., PMID:18469855
Notch1, Jagged1, and HES5 are abundantly expressed in osteoarthritis., PMID:18354251
COUP-TFI controls Notch regulation of hair cell and support cell differentiation., PMID:16914494
Segmental expression of Notch and Hairy genes in nephrogenesis., PMID:15821257
NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch., PMID:15496460
Specification of vertebral identity is coupled to Notch signalling and the segmentation clock., PMID:14960495
Expression of Hes6 and NeuroD in the olfactory epithelium, vomeronasal organ and non-sensory patches., PMID:12714442
Regulation of cerebral cortical size by control of cell cycle exit in neural precursors., PMID:12130776
Regulated expression of neurogenic basic helix-loop-helix transcription factors during differentiation of the immortalized neuronal progenitor cell line HC2S2 into neurons., PMID:9634594
For research use only. Not for human or drug use.
