Catalog No.
PHK76201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human HES5 (Met1-Arg121).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000 |
Target
BHLHB38, Transcription factor HES-5, Class B basic helix-loop-helix protein 38, bHLHb38, Hairy and enhancer of split 5, HES5
Purification
Purified by antigen affinity column.
Accession
Q5TA89
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Regulated expression of neurogenic basic helix-loop-helix transcription factors during differentiation of the immortalized neuronal progenitor cell line HC2S2 into neurons., PMID:9634594
Regulation of cerebral cortical size by control of cell cycle exit in neural precursors., PMID:12130776
Expression of Hes6 and NeuroD in the olfactory epithelium, vomeronasal organ and non-sensory patches., PMID:12714442
Specification of vertebral identity is coupled to Notch signalling and the segmentation clock., PMID:14960495
NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch., PMID:15496460
Segmental expression of Notch and Hairy genes in nephrogenesis., PMID:15821257
COUP-TFI controls Notch regulation of hair cell and support cell differentiation., PMID:16914494
Notch1, Jagged1, and HES5 are abundantly expressed in osteoarthritis., PMID:18354251
ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor., PMID:18469855
Down-regulation of Notch signaling during corneal epithelial proliferation., PMID:18552977
Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice., PMID:18950867
BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage., PMID:19074416
Notch signaling is required for lateral induction of Jagged1 during FGF-induced lens fiber differentiation., PMID:19481073
The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina., PMID:19490914
Molecular characterization of human retinal progenitor cells., PMID:19553622
Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1., PMID:19598246
Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells., PMID:19682396
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors., PMID:20161710
Immunohistochemical expression of Notch signaling in the lining epithelium of periapical cysts., PMID:21238798
A monoclonal antibody against human Notch1 ligand-binding domain depletes subpopulation of putative breast cancer stem-like cells., PMID:22075160
Glycogen synthase kinase-3 inhibition promotes proliferation and neuronal differentiation of human-induced pluripotent stem cell-derived neural progenitors., PMID:22642687
Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells., PMID:22842086
Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants., PMID:23042297
Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12, and 13, and the HLA class II region., PMID:23460240
Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice., PMID:26034172
Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition., PMID:26115193
Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina., PMID:26116667
Effect of IL-17 monoclonal antibody Secukinumab combined with IL-35 blockade of Notch signaling pathway on the invasive capability of hepatoma cells., PMID:27420998
Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis., PMID:27564686
A Brief Report of Immunohistochemical Markers to Identify Aggressive Hepatoblastoma., PMID:28187036
The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone., PMID:29037852
Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression., PMID:32650029
Pancreatic-Like Cells Derived From Mouse Embryonic Stem Cells Are Regulated by Pdx1 Involving the Notch Pathway., PMID:35695761
For research use only. Not for human or drug use.
