Catalog No.
PHE40501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human MSH2 (Glu12-Asp295).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
hMSH2, MutS protein homolog 2, MSH2, DNA mismatch repair protein Msh2
Purification
Purified by antigen affinity column.
Accession
P43246
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Immunohistochemical and molecular evolutionary features of jejunoileal adenocarcinoma unveiled through comparative analysis with colorectal adenocarcinoma., PMID:40403397
Detecting microsatellite instability in cancer via multiplexed orthogonal gap-enhanced Raman tags., PMID:40386153
Comparison of survival outcomes for patients with Lynch vs non-Lynch syndrome and microsatellite unstable colorectal cancer treated with immunotherapy., PMID:39932790
Case report: Chemotherapy plus sintilimab for the treatment of gastroesophageal junction hepatoid adenocarcinoma with liver metastasis: a case study with literature review., PMID:39931054
[Application of PMS2 and MSH6 double-antibody detection in screening of mismatch repair deficient tumors]., PMID:39863527
Intraoperative rapid immunohistochemistry of microsatellite instability using non-contact alternating current electric field mixing., PMID:39443409
Single Center Characterization of a Cohort of Salivary Gland Carcinomas., PMID:39337873
Durable response to pembrolizumab in hepatic metastasis from colonic carcinoma with Lynch syndrome: a case report., PMID:39247185
Universal testing in endometrial cancer in Sweden., PMID:39175077
Intriguing Insights From 100 Consecutive Colorectal Cancer Cases in Mid-Kerala: Sparse BRAF Gene Mutations and Mismatch Repair Deficiency (MMR-D)., PMID:39119381
Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective., PMID:39102671
Mismatch repair deficiency: how reliable is the two-antibody approach? A national real-life study., PMID:38859771
Diagnostic and prognostic assessments of adrenocortical carcinomas by pathological features, immunohistochemical markers and reticular histochemistry staining., PMID:38802933
Assessing Mismatch Repair Expression by Immunohistochemistry in Colorectal Adenocarcinoma -Insight from a Tertiary Care Centre., PMID:38774931
The Relationship of Microsatellite Instability with BRAF and p53 Mutations and Histopathological Parameters in Colorectal Adenocarcinoma., PMID:38684491
[Expression of immune checkpoints PD-L1, CTLA4, LAG3 in the microenvironment of colon adenocarcinoma depending on MMR status]., PMID:38591901
HER2-low and Overexpression in Mucinous Ovarian Cancer: Analysis of ASCO/CAP and ToGA Immunohistochemical Scoring., PMID:38436360
Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern., PMID:38394410
Next-generation sequencing and immunohistochemistry approaches for microsatellite instability detection in endometrial cancer., PMID:38279425
The relationship between DNA mismatch repair gene and other prognostic parameters in pancreatic adenocarcinoma., PMID:38173349
Clinicopathologic features of conjunctival MALT lymphomas refractory to radiation therapy., PMID:38101452
Expression of Programmed Cell Death Ligand-1 and Mismatch Repair Status in Endometrial Carcinomas., PMID:38029026
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy., PMID:37932012
Deficient Mismatch Repair Proteins in Gastric Mixed Neuroendocrine Non-Neuroendocrine Neoplasm: A Rare Case Report., PMID:37900850
Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial)., PMID:37819940
Deep Learning Can Predict Bevacizumab Therapeutic Effect and Microsatellite Instability Directly from Histology in Epithelial Ovarian Cancer., PMID:37741509
Rechallenge With Switching Immune Checkpoint Inhibitors Following Autoimmune Myocarditis in a Patient With Lynch Syndrome., PMID:37673116
Mismatch Repair Deficient (dMMR) Colorectal Carcinoma in a Pakistani Cohort: Association With Clinical and Pathological Parameters., PMID:37664303
Mismatch Repair Protein Expression in Endometrial Cancer: Assessing Concordance and Unveiling Pitfalls in Two Different Immunohistochemistry Assays., PMID:37623510
Early-Onset/Young-Onset Colorectal Carcinoma: A Comparative Analysis of Morphological Features and Biomarker Profile., PMID:37621838
A pathological complete response after immunotherapy with pembrolizumab for distal duodenal adenocarcinoma caused by Lynch syndrome: a case report., PMID:37577343
A Japanese case of ovarian mucinous adenocarcinoma with germline double variants of MSH2 and BRCA2., PMID:37420004
Short-term immune-checkpoint inhibition partially rescues perturbed bone marrow hematopoiesis in mismatch-repair deficient tumors., PMID:37396958
Mixed acinar-neuroendocrine carcinoma of the pancreas with positive for microsatellite instability: a case report and review of the literature., PMID:37386324
MTHFR act as a potential cancer biomarker in immune checkpoints blockades, heterogeneity, tumor microenvironment and immune infiltration., PMID:37354330
The expression of programmed death-ligand 1 and programmed death-ligand 2 in endometrial carcinosarcoma: Correlation with mismatch repair protein expression status, tumor-infiltrating lymphocyte infiltration, and clinical outcomes., PMID:37060883
Complete Response to Immune Checkpoint Inhibition in a Platinum Resistant Primary Ovarian Cancer Patient With Lynch Syndrome: A Case Report and Review of the Literature., PMID:36974818
Lymph-node metastasis from gastric adenocarcinoma in a patient bearing a germ line missense variant MSH2 c.1808A > T (Asp603Val) responds to the immune checkpoint inhibitor pembrolizumab., PMID:36484308
[Microsatellite instability in gastric cancer is a predictor of a favorable prognosis]., PMID:36469712
Correlation of PD-L1 immunohistochemical expression with microsatellite instability and p53 status in endometrial carcinoma., PMID:36440057
Mismatch repair proteins expression and tumor-infiltrating T-cells in colorectal cancer., PMID:36276483
Validity of a two-antibody testing algorithm for mismatch repair deficiency testing in cancer; a systematic literature review and meta-analysis., PMID:36104536
An Evaluation of the Immunohistochemical Expression of Mismatch Repair Proteins (MSH2, MSH6, MLH1, and PMS2) in Prostate Adenocarcinoma., PMID:36051725
Mismatch Repair Deficiency in Adult Granulosa Cell Tumors: an Immunohistochemistry-based Preliminary Study., PMID:35960021
Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers., PMID:35896284
CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors., PMID:35845723
A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus-like Disease in Mice., PMID:35708944
Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma., PMID:35668940
Immunotherapy in Penile Squamous Cell Carcinoma: Present or Future? Multi-Target Analysis of Programmed Cell Death Ligand 1 Expression and Microsatellite Instability., PMID:35592855
A case of microsatellite instability-high clinically advanced castration-resistant prostate cancer showing a remarkable response to pembrolizumab sustained over at least 18 months., PMID:35487690
For research use only. Not for human or drug use.
