Catalog No.
PHH18501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SLC1A5 (Gln154-Asn230).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Baboon M7 virus receptor, SLC1A5, Solute carrier family 1 member 5, ASCT2, RDR, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, ATB(0), Neutral amino acid transporter B(0), M7V1, RDRC
Purification
Purified by antigen affinity column.
Accession
Q15758
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
ATF4 promotes glutaminolysis and glycolysis in colorectal cancer by transcriptionally inducing SLC1A5., PMID:39696988
HMGA2-mediated glutamine metabolism is required for Cd-induced cell growth and cell migration., PMID:39032683
ASCT2-Targeting Antibody-Drug Conjugate MEDI7247 in Adult Patients with Relapsed/Refractory Hematological Malignancies: A First-in-Human, Phase 1 Study., PMID:38683495
GLUT1 and ASCT2 expression and their prognostic value in colorectal carcinoma., PMID:38394402
ASCT2-mediated glutamine uptake of epithelial cells facilitates CCL5-induced T cell infiltration via ROS-STAT3 pathway in oral lichen planus., PMID:37116342
Inhibition of Glutamine Uptake Improves the Efficacy of Cetuximab on Gastric Cancer., PMID:34590499
The role of the glutamine transporter ASCT2 in antineoplastic therapy., PMID:33464409
Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions., PMID:33256735
Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation., PMID:31862915
ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma., PMID:31819178
Anti-tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS-mutated human colorectal cancer cells., PMID:31709772
Generation of a neutralizing antibody against RD114-pseudotyped viral vectors., PMID:31702531
Glucose and glutamine metabolism in relation to mutational status in NSCLC histological subtypes., PMID:31668020
Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma., PMID:31578313
Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome., PMID:30582284
An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models., PMID:30210919
Inhibition of SLC1A5 sensitizes colorectal cancer to cetuximab., PMID:29363109
miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma., PMID:29348676
Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients., PMID:29337138
Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors., PMID:29020998
AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis., PMID:28823958
Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer., PMID:28804556
ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production., PMID:28553292
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis., PMID:28512249
Establishment of monoclonal antibodies against cell surface domains of ASCT2/SLC1A5 and their inhibition of glutamine-dependent tumor cell growth., PMID:27865832
ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis., PMID:27450723
Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta., PMID:26875564
Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo., PMID:26154387
Functional analyse of GLUT1 and GLUT12 in glucose uptake in goat mammary gland epithelial cells., PMID:23724114
Cellular distribution of the neutral amino acid transporter subtype ASCT2 in mouse brain., PMID:19012749
Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core., PMID:17962467
Glutamine availability up-regulates expression of the amino acid transporter protein ASCT2 in HepG2 cells and stimulates the ASCT2 promoter., PMID:15175006
Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas., PMID:15094455
Biodistribution of the RD114/mammalian type D retrovirus receptor, RDR., PMID:15026986
Expression of neutral amino acid transporter ASCT2 in human prostate., PMID:12926082
Na(+)-dependent neutral amino acid transporter ATB(0) is a rabbit epithelial cell brush-border protein., PMID:11502573
For research use only. Not for human or drug use.
