Catalog No.
PHG08601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human RBPJ (Arg30-Gly345).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Recombining binding protein suppressor of hairless, RBP-J, IGKJRB, CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, IGKJRB1, RBPJ, Renal carcinoma antigen NY-REN-30, RBPSUH, RBPJK
Purification
Purified by antigen affinity column.
Accession
Q06330
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Immunosuppressive JAG2+ tumor-associated neutrophils hamper PD-1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells., PMID:40120139
Autoantibody profiling of patients with immune checkpoint inhibitor-associated myocarditis: a pilot study., PMID:39324142
NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α., PMID:37865314
Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8+ T cells in hepatocellular carcinoma., PMID:36717584
miR-375 upregulates lipid metabolism and inhibits cell proliferation involved in chicken fatty liver formation and inheritance via targeting recombination signal binding protein for immunoglobulin kappa J region (RBPJ)., PMID:36410068
Notch effector recombination signal binding protein for immunoglobulin kappa J signaling is required for the initiation of endometrial stromal cell decidualization†., PMID:35835555
Tumor-associated macrophages (TAMs) modulate response to HER2-targeted agents in a humanized mouse model of breast cancer., PMID:35212924
Pharmacological disruption of the Notch transcription factor complex., PMID:32601208
M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis., PMID:32378114
Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes., PMID:29889863
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI., PMID:28877478
Notch2 blockade enhances hematopoietic stem cell mobilization and homing., PMID:28729299
G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling., PMID:27926858
Notch3 drives development and progression of cholangiocarcinoma., PMID:27791012
Central role for marginal zone B cells in an animal model of Sjogren's syndrome., PMID:27140729
Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells., PMID:26188077
Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence., PMID:25385755
Hes1 suppresses acute myeloid leukemia development through FLT3 repression., PMID:25234168
Notch-dependent RBPJκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts., PMID:24850908
Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis., PMID:23921886
The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation., PMID:23698100
Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development., PMID:23319657
Immunohistochemical analysis of medullary breast carcinoma autoantigens in different histological types of breast carcinomas., PMID:23181716
Notch-RBP-J-independent marginal zone B cell development in IgH transgenic mice with VH derived from a natural polyreactive antibody., PMID:22719978
Serum autoantibody signature of ductal carcinoma in situ progression to invasive breast cancer., PMID:22322670
Direct regulation of interleukin-6 expression by Notch signaling in macrophages., PMID:21983868
Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo., PMID:21898486
Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac., PMID:21352545
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci., PMID:20453842
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin., PMID:20174635
Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice., PMID:18950867
Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1., PMID:16439682
A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent., PMID:15994772
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells., PMID:15879553
Quantification of Jkappa signal end breaks in developing B cells by blunt-end linker ligation and qPCR., PMID:15680147
Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways., PMID:14701863
Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling., PMID:12832621
[LIM protein KyoT2 interacts with human tight junction protein ZO-2-i3]., PMID:12645256
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells., PMID:11967543
[Screening and detecting of proteins interaction with KyoT]., PMID:11902002
Characterization of tissue-specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM-only protein (FHL1)., PMID:11400158
Notch signaling as a target in multimodality cancer therapy., PMID:11249652
Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia., PMID:10974024
Regulation of the Epstein-Barr virus C promoter by AUF1 and the cyclic AMP/protein kinase A signaling pathway., PMID:10933728
Functional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa/CBF1., PMID:10773077
Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2., PMID:10644343
Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells., PMID:10637481
Enhanced expression and autoimmunity of recombination signal binding protein-jkappa in human dilated cardiomyopathy., PMID:10600520
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex., PMID:9874765
Delta-1 activation of notch-1 signaling results in HES-1 transactivation., PMID:9819428
For research use only. Not for human or drug use.
