Anti-Human AIRE Polyclonal Antibody

Catalog No.

PHA82101

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human AIRE (Ala2-Asp105).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

AIRE, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, Autoimmune regulator, APECED, APECED protein

Purification

Purified by antigen affinity column.

Accession

O43918

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Pernicious Anemia in a Pediatric Patient With Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy., PMID:40322634

Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα., PMID:40304722

RORγt eTACs mediate oral tolerance and Treg induction., PMID:40298935

Autoimmune hyperglycemia: beyond type 1 diabetes., PMID:40252101

Aire Mutations and Autoimmune Diseases., PMID:40067589

Aire attenuate collagen-induced arthritis by suppressing T follicular helper cells through ICOSL., PMID:39626537

Where AIRE we now? Where AIRE we going?, PMID:39440452

Trio-based exome sequencing and high-resolution HLA typing in families of patients with autoimmune adrenal insufficiency and autoimmune polyglandular syndrome., PMID:39423205

Reduction in mucosal-associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN-γ concentration., PMID:39292205

Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED., PMID:39113427

Lymphocyte-Directed Immunomodulation Remits Thymoma-Associated Autoimmune Pneumonitis., PMID:38954150

Neurological Diseases and Prevalence of Antineuronal Antibodies in Patients with Autoimmune Polyendocrine Syndrome Type 1 - A National Cohort Study., PMID:38829425

JAK Inhibition Immunotherapy for APS-1., PMID:38810191

The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1., PMID:38810185

Lessons From Prospective Longitudinal Follow-up of a French APECED Cohort., PMID:38605470

Interferon autoantibodies as signals of a sick thymus., PMID:38455040

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4., PMID:38383779

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification., PMID:38260362

Dysregulated germinal center reaction with expanded T follicular helper cells in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy lymph nodes., PMID:38128835

Ruxolitinib Rescues Multiorgan Clinical Autoimmunity in Patients with APS-1., PMID:38112858

Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease., PMID:37993717

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency., PMID:37938781

Validation of a murine proteome-wide phage display library for identification of autoantibody specificities., PMID:37934865

Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974

Safety and efficacy of benralizumab in elderly subjects with severe asthma., PMID:37737844

Characterization of autoimmune eye disease in association with Down's syndrome., PMID:37598261

Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade., PMID:37369658

Characterization of autoimmune eye disease in association with Down's Syndrome., PMID:37205347

Interleukin-17A knockout or self-recovery alleviated autoimmune reaction induced by fluoride in mouse testis., PMID:37086998

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities., PMID:37066405

Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1., PMID:37052889

Autoantibodies targeting type I interferons: Prevalence, mechanisms of induction, and association with viral disease susceptibility., PMID:37027328

Mild COVID-19 in an APECED Patient with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and High Titer of Type 1 IFN-Abs: A Case Report., PMID:36986325

Muscle and Muscle-like Autoantigen Expression in Myasthenia Gravis Thymus: Possible Molecular Hint for Autosensitization., PMID:36979710

Case report: Discovery of a de novo FAM111B pathogenic variant in a patient with an APECED-like clinical phenotype., PMID:36875114

Case report: Virus-induced hemophagocytic lymphohistiocytosis in a patient with APECED., PMID:36873640

Spontaneous development of an autoimmune hepatitis - primary biliary cholangitis overlap syndrome in dnTGFβRII Aire-/- mice., PMID:36853094

Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs., PMID:36719370

A non-classical presentation of APECED in a family with heterozygous R203X AIRE gene mutation., PMID:36251243

Screening patients with autoimmune endocrine disorders for cytokine autoantibodies reveals monogenic immune deficiencies., PMID:36191466

Reliability, Satisfaction and Effectiveness of Benralizumab Home Self-Administration in Patients with Severe Eosinophilic Asthma in Real-World Practice: The Auto-Benra Study., PMID:35592384

Anti-RANKL Inhibits Thymic Function and Causes DRONJ in Mice., PMID:35464103

Anti-CD45RC antibody immunotherapy prevents and treats experimental autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome., PMID:35167497

Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity., PMID:35058362

Attenuation of Autoimmune Phenomena in a Patient with Autoimmune Polyglandular Syndrome Type 1., PMID:34938581

Functional screen of inflammatory bowel disease genes reveals key epithelial functions., PMID:34758847

Patients with autoimmune polyendocrine syndrome type 1 have an increased susceptibility to severe herpesvirus infections., PMID:34508889

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