Catalog No.
PHE99201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human LIMK1 (Gly419-Asp647).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
LIMK-1, LIMK, LIMK1, LIM domain kinase 1
Purification
Purified by antigen affinity column.
Accession
P53667
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
RhoA-LIMK Signaling Axis Reveals Rostral-Caudal Plane and Spatial Dysregulation in the Brain of Alzheimer's Disease Mouse Models., PMID:37718806
Inhibition of airway smooth muscle contraction and proliferation by LIM kinase inhibitor, LIMKi3., PMID:37148787
Involvement of Paired Immunoglobulin-Like Receptor B in Cognitive Dysfunction Through Hippocampal-Dependent Synaptic Plasticity Impairments in Mice Subjected to Chronic Sleep Restriction., PMID:36417104
Effect of resistance training on satellite cells in old mice - a transcriptome study : implications for sarcopenia., PMID:35188421
The Role of LIM Kinase in the Male Urogenital System., PMID:35011645
LIMK1 nuclear translocation promotes hepatocellular carcinoma progression by increasing p-ERK nuclear shuttling and by activating c-Myc signalling upon EGF stimulation., PMID:33686242
Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α4β7 integrin antibody., PMID:30662943
Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron., PMID:30024789
MART-10, a 1α,25(OH)2D3 Analog, Potently Represses Metastasis of ER+ Breast Cancer Cells with VEGF-A Overexpression., PMID:29970508
Inhibition of human prostate smooth muscle contraction by the LIM kinase inhibitors, SR7826 and LIMKi3., PMID:29574791
The serum protein profile of early parity which induces protection against breast cancer., PMID:27769065
LIMK1/2 inhibitor LIMKi 3 suppresses porcine oocyte maturation., PMID:27761340
Bonafide Targets of Deregulated microRNAs in Non-Small Cell Lung Cancer as Tool to Identify Novel Therapeutic Targets: A Review., PMID:27719642
LIM kinase activity is required for microtubule organising centre positioning in mouse oocyte meiosis., PMID:26733281
Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study., PMID:25971815
The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1)., PMID:23303955
The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells., PMID:23119107
The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments., PMID:22670058
The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination., PMID:22496574
YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification., PMID:21423216
The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migration., PMID:21297993
Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis., PMID:21167960
Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity., PMID:19553453
BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity., PMID:19001503
Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis., PMID:18978953
Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis., PMID:18160398
Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks., PMID:17981134
Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer., PMID:17559677
Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease., PMID:16775141
LIM kinase 2 is widely expressed in all tissues., PMID:16399995
LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system., PMID:16381000
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1., PMID:15220930
Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing., PMID:15189451
LIM kinase 1, a key regulator of actin dynamics, is widely expressed in embryonic and adult tissues., PMID:15023529
Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin., PMID:14531860
Suppression of cofilin phosphorylation in insulin-stimulated ruffling membrane formation in KB cells., PMID:12655149
Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis., PMID:11925442
LIM kinase 1 modulates opsonized zymosan-triggered activation of macrophage-like U937 cells. Possible involvement of phosphorylation of cofilin and reorganization of actin cytoskeleton., PMID:11694543
A protein kinase from neutrophils that specifically recognizes Ser-3 in cofilin., PMID:10644754
LIM kinase 1 accumulates in presynaptic terminals during synapse maturation., PMID:10602091
LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family., PMID:7651734
For research use only. Not for human or drug use.
