Catalog No.
PHB05001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human NBN (Met1-Asp121).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Nibrin, P95, NBS1, Cell cycle regulatory protein p95, NBS, Nijmegen breakage syndrome protein 1, NBN
Purification
Purified by antigen affinity column.
Accession
O60934
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis., PMID:38908771
Comprehensive characterization of genomic features and clinical outcomes following targeted therapy and secondary cytoreductive surgery in OCCC: a single center experience., PMID:38606821
Safety, immunogenicity and efficacy of an mRNA-based COVID-19 vaccine, GLB-COV2-043, in preclinical animal models., PMID:38040905
Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis., PMID:37652913
Antibodies Produced in Response to a Live-Attenuated Dengue Vaccine Are Functional in Activating the Complement System., PMID:36461942
Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A., PMID:32313230
PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy., PMID:31053471
Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model., PMID:27467592
Clinical course and therapeutic implications for lymphoid malignancies in Nijmegen breakage syndrome., PMID:26826318
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes., PMID:26405826
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells., PMID:26073085
Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation., PMID:25485873
Impact of α-targeted radiation therapy on gene expression in a pre-clinical model for disseminated peritoneal disease when combined with paclitaxel., PMID:25268703
Pulmonary coccidioidomycosis: pictorial review of chest radiographic and CT findings., PMID:25019431
The MRN-CtIP pathway is required for metaphase chromosome alignment., PMID:23434370
High LET radiation amplifies centrosome overduplication through a pathway of γ-tubulin monoubiquitination., PMID:23433796
The defect in humoral immunity in patients with Nijmegen breakage syndrome is explained by defects in peripheral B lymphocyte maturation., PMID:22851427
[Heterozygous carriers of Slavic mutation 657del5 of NBN gene in patients with colorectal cancer]., PMID:21560448
siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells., PMID:21501031
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1., PMID:21297581
Autophosphorylation and ATM activation: additional sites add to the complexity., PMID:21149446
UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells., PMID:20947453
Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex., PMID:20943970
MCL-1 localizes to sites of DNA damage and regulates DNA damage response., PMID:20647761
Loss of juxtaposition of RAG-induced immunoglobulin DNA ends is implicated in the precursor B-cell differentiation defect in NBS patients., PMID:20378756
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair., PMID:20081839
Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation., PMID:19896956
DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories., PMID:19597347
Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1., PMID:19338747
Unique morphological spectrum of lymphomas in Nijmegen breakage syndrome (NBS) patients with high frequency of consecutive lymphoma formation., PMID:18788073
Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites., PMID:18582474
Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats., PMID:18253720
Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling., PMID:18248856
NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse., PMID:18003706
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients., PMID:17786349
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain., PMID:17706468
Defective signal joint recombination in fanconi anemia fibroblasts reveals a role for Rad50 in V(D)J recombination., PMID:17524422
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis., PMID:17485521
The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity., PMID:17121922
Heat-induced phosphorylation of NBS1 in human skin fibroblast cells., PMID:16823774
The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions., PMID:15937485
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response., PMID:15916964
Nibrin functions in Ig class-switch recombination., PMID:15668383
Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain., PMID:15635255
The clinical and biological overlap between Nijmegen Breakage Syndrome and Fanconi anemia., PMID:15451479
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention., PMID:15201865
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts., PMID:15199173
Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks., PMID:15180989
Retrospective diagnosis and subsequent prenatal diagnosis of Nijmegen breakage syndrome., PMID:14974117
Arsenic-induced Mre11 phosphorylation is cell cycle-dependent and defective in NBS cells., PMID:12509260
For research use only. Not for human or drug use.
