Catalog No.
PHC22601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SERPINE2 (Ser20-Pro398).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
SERPINE2, Protease nexin I, Protease nexin 1, GDN, Glia-derived nexin, PN-1, Serpin E2, Peptidase inhibitor 7, PI7, PN1, PI-7
Purification
Purified by antigen affinity column.
Accession
P07093
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
PAI-1 production by reactive astrocytes drives tissue dysfibrinolysis in multiple sclerosis models., PMID:35633384
Transcripts associated with chronic lung allograft dysfunction in transbronchial biopsies of lung transplants., PMID:34850543
BAP31 Promotes Tumor Cell Proliferation by Stabilizing SERPINE2 in Hepatocellular Carcinoma., PMID:33363167
Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy., PMID:33026832
Integrated transcriptomic correlation network analysis identifies COPD molecular determinants., PMID:32099002
Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells., PMID:32001531
Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart., PMID:31723062
Protease Nexin I is a feedback regulator of EGF/PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness., PMID:31501409
Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1., PMID:30099074
Inhibition of SERPINE2/protease nexin-1 by a monoclonal antibody attenuates airway remodeling in a murine model of asthma., PMID:31966548
Clearance of plasmin-PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta., PMID:29149696
Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice., PMID:28270519
Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages., PMID:27793045
Hyperglycemia-suppressed expression of Serpine1 contributes to delayed epithelial wound healing in diabetic mouse corneas., PMID:26024123
Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke., PMID:25540192
Cross-talk between human mast cells and bronchial epithelial cells in plasminogen activator inhibitor-1 production via transforming growth factor-β1., PMID:24987792
Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury., PMID:24920753
Roles of Coagulation and fibrinolysis in angiotensin II-enhanced microvascular thrombosis., PMID:24495184
Three monoclonal antibodies against the serpin protease nexin-1 prevent protease translocation., PMID:24085288
Involvement of the serine protease inhibitor, SERPINE2, and the urokinase plasminogen activator in cumulus expansion and oocyte maturation., PMID:24023701
Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition., PMID:23661674
Vitronectin dictates intraglomerular fibrinolysis in immune-mediated glomerulonephritis., PMID:21764994
Involvement of NADPH oxidase in up-regulation of plasminogen activator inhibitor-1 and heat shock factor-1 in mouse embryo fibroblasts induced by oxidized LDL and in apolipoprotein E-deficient mice., PMID:21651452
Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase., PMID:21540184
SERPINE2, an inhibitor of plasminogen activators, is highly expressed in the human endometrium during the secretory phase., PMID:21426587
Platelet protease nexin-1, a serpin that strongly influences fibrinolysis and thrombolysis., PMID:21403095
Development and optimization of an antibody array method for potential cancer biomarker detection., PMID:23554673
TWEAK-Fn14 interaction enhances plasminogen activator inhibitor 1 and tissue factor expression in atherosclerotic plaques and in cultured vascular smooth muscle cells., PMID:20810696
C5a receptor targeting in neointima formation after arterial injury in atherosclerosis-prone mice., PMID:20733098
Anticoagulant and antithrombotic properties of platelet protease nexin-1., PMID:19855083
Positive feedback loop between plasminogen activator inhibitor-1 and transforming growth factor-beta1 during renal fibrosis in diabetes., PMID:19786738
Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism., PMID:19472211
Plasminogen activator inhibitor-1 (PAI-1) facilitates retinal angiogenesis in a model of oxygen-induced retinopathy., PMID:19443721
Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo., PMID:19308290
Protease nexin-1, tPA, and PAI-1 are upregulated in cryoglobulinemic membranoproliferative glomerulonephritis., PMID:18199802
Protease-activated receptor-2 augments experimental crescentic glomerulonephritis., PMID:17640968
Serine protease inhibitor-E2 (SERPINE2) is differentially expressed in granulosa cells of dominant follicle in cattle., PMID:12506347
Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV., PMID:12356769
Serpins in the human hair follicle., PMID:10771471
Analysis of a structural determinant in thrombin-protease nexin 1 complexes that mediates clearance by the low density lipoprotein receptor-related protein., PMID:9867841
Excitotoxic brain lesion modifies binding to a USF binding site acting as a negative regulatory element in the Protease nexin-1 promoter., PMID:8923453
Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease., PMID:7704602
Protease nexin-1-urokinase complexes are internalized and degraded through a mechanism that requires both urokinase receptor and alpha 2-macroglobulin receptor., PMID:8027043
Co-distribution of protease nexin-1 and protease nexin-2 in brains of non-human primates., PMID:8281456
Protease nexin 1 is expressed in the human placenta., PMID:8456423
Tissue factor pathway inhibitor and protease nexin-1 are major factor Xa binding proteins on the HepG2 cell surface., PMID:8381308
Inhibitors of urokinase and thrombin in cultured neural cells., PMID:1987320
Protease nexin-1. Localization in the human brain suggests a protective role against extravasated serine proteases., PMID:2221008
Binding of protease nexin-1 to the fibroblast surface alters its target proteinase specificity., PMID:2642483
Purification of a form of protease nexin 1 that binds heparin with a low affinity., PMID:3378053
For research use only. Not for human or drug use.
