Catalog No.
PHE26801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human VHL (Glu70-Asp213).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
VHL, pVHL, Protein G7, von Hippel-Lindau disease tumor suppressor
Purification
Purified by antigen affinity column.
Accession
P40337
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Casdatifan (AB521) is a novel and potent allosteric small molecule inhibitor of protumourigenic HIF-2α dependent transcription., PMID:40400177
Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study., PMID:40352587
A synthetic heavy chain variable domain antibody library (VHL) provides highly functional antibodies with favorable developability., PMID:40100169
A neoantigen vaccine generates antitumour immunity in renal cell carcinoma., PMID:39910301
Immunohistochemical Expression of PAX8 in Central Nervous System Hemangioblastomas: A Potential Diagnostic Pitfall for Neuropathologists., PMID:39807616
Biomarker analyses from the phase III randomized CLEAR trial: lenvatinib plus pembrolizumab versus sunitinib in advanced renal cell carcinoma., PMID:39672382
Neutralizing antibodies in milk and blood of lactating women vaccinated for SARS-CoV-2: a systematic review., PMID:39258663
Clinical significance of circulating biomarkers of immune-checkpoint molecules with atezolizumab plus bevacizumab therapy in unresectable hepatocellular carcinoma., PMID:38963640
Evaluation of the diagnostic utility of NCOA3, Maspin and VHL protein expression in pancreatic ductal adenocarcinoma: An immunohistochemical study., PMID:38901088
Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs., PMID:38818652
Polyphyllin I ameliorates gefitinib resistance and inhibits the VEGF/VEGFR2/p38 pathway by targeting HIF-1a in lung adenocarcinoma., PMID:38761523
Clinical Implications of a Six-Protein Signature in Bone Metastasis of Renal Cell Carcinoma., PMID:38706914
[Modern view on the problem of diagnostics of renal angiomioadenomatous tumor]., PMID:38650412
Association of the combined parameters including the frequency of primary cilia, PD-L1, Smoothened protein, membranous β-catenin and cytoplasmic β-catenin expression with the outcome of patients with clear cell renal cell carcinoma., PMID:38420990
VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation., PMID:38360997
A Phase 2 Trial of Talazoparib and Avelumab in Genomically Defined Metastatic Kidney Cancer., PMID:37945488
An Overview of Renal Cell Carcinoma Hallmarks, Drug Resistance, and Adjuvant Therapies., PMID:37927802
Genomic analysis of plasma circulating tumor DNA in patients with heavily pretreated HER2 + metastatic breast cancer., PMID:37336919
Genetic mutations in HER2-positive breast cancer: possible association with response to trastuzumab therapy., PMID:37202799
Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma., PMID:37069149
Therapeutic Management of Metastatic Clear Cell Renal Cell Carcinoma: A Revolution in Every Decade., PMID:36551715
Correlation between ABO blood type, susceptibility to SARS-CoV-2 infection and COVID-19 disease severity: A systematic review., PMID:36467112
PD-L1 expression and association with genetic background in pheochromocytoma and paraganglioma., PMID:36439433
Developmentally Arrested Basket/Stellate Cells in Postnatal Human Brain as Potential Tumor Cells of Origin for Cerebellar Hemangioblastoma in von Hippel-Lindau Patients., PMID:35980299
Hypoxia-inducible factor pathway genes predict survival in metastatic clear cell renal cell carcinoma., PMID:35973929
IL6 and CCL18 Mediate Cross-talk between VHL-Deficient Kidney Cells and Macrophages during Development of Renal Cell Carcinoma., PMID:35666812
Potential of Anti-CMV Immunoglobulin Cytotect CP® In Vitro and Ex Vivo in a First-Trimester Placenta Model., PMID:35456746
Strategies to Reduce the On-Target Platelet Toxicity of Bcl-xL Inhibitors: PROTACs, SNIPERs and Prodrug-Based Approaches., PMID:35263486
Early dynamics of circulating tumor DNA predict clinical response to immune checkpoint inhibitors in metastatic renal cell carcinoma., PMID:35184335
In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells., PMID:35145086
Deep Membrane Proteome Profiling Reveals Overexpression of Prostate-Specific Membrane Antigen (PSMA) in High-Risk Human Paraganglioma and Pheochromocytoma, Suggesting New Theranostic Opportunity., PMID:34770976
Multimodal image-guided ablation on management of renal cancer in Von-Hippel-Lindau syndrome patients from 2004 to 2021 at a specialist centre: A longitudinal observational study., PMID:34728141
Intravitreous treatment of severe ocular von Hippel-Lindau disease using a combination of the VEGF inhibitor, ranibizumab and PDGF inhibitor, E10030: Results from a phase 1/2 clinical trial., PMID:34549489
Association of AXL and PD-L1 Expression with Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma Treated with PD-1 Blockade., PMID:34407968
Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer., PMID:34377597
Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP., PMID:34038131
Selective and noncovalent targeting of RAS mutants for inhibition and degradation., PMID:33976200
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy., PMID:33596073
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties., PMID:33596065
Acute Kidney Injury Instigates Malignant Renal Cell Carcinoma via CXCR2 in Mice with Inactivated Trp53 and Pten in Proximal Tubular Kidney Epithelial Cells., PMID:33558337
Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway., PMID:33354501
Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3., PMID:33332748
Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade., PMID:33157048
A systematic literature review and meta-analysis of risk factors for Neospora caninum seroprevalence in goats., PMID:33129022
c-Met expression in renal cell carcinoma with bone metastases., PMID:33024658
Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains., PMID:32807795
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System., PMID:32668203
A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS., PMID:32591521
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma., PMID:32472114
Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients., PMID:32194829
For research use only. Not for human or drug use.
